Biomedical papers - Latest articles
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Macular pigment evaluation using dual-wavelength fundus auto-fluorescence imagingOriginal papers
Patrik Rajs, Ivana Liehneova, Zbynek Stranak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):144-148 | DOI: 10.5507/bp.2023.051 
This study aimed to investigate changes in fundus autofluorescence in patients taking daily lutein oral supplements and to develop image processing methods for follow-up evaluations of the images. Dual wavelength fundus autofluorescence is a valuable technique for macular pigment evaluation in follow-up examinations, utilizing software image post-processing with commonly available hardware.
Peripapillary retinal nerve fiber layer following vessel density correction at different IOP valuesOriginal papers
Jan Lestak, Martin Fus, Sarka Pitrova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):140-143 | DOI: 10.5507/bp.2024.001
In this study of early changes in glaucoma, the authors show that when the thickness of the retinal nerve fiber layer (RNFL) was reduced by correcting for vessel density (VD), there was a significant correlation between segments 5 (Superior Nasal) (r =-0.32, P<0.05) and 8 (Inferior Nasal) (r =-0.21, P<0.05) and degree of intraocular pressure. Use of this corrected RNFL from VD is a more appropriate method for detecting early changes in glaucoma. The above has been filed with the Patent and Invention Office under application number: PV 2023-234.
Determination of the prevalence and predictors of ventricular thrombus with assessment of the risk of systemic embolization to the CNS in patients after acute myocardial infarction using magnetic resonance imaging, echocardiography and cardiac markers - a prospective, unicentric, observational studyOriginal papers
Stepan Hudec, Martin Hutyra, Jan Precek, Jan Latal, Radomir Nykl, Miloslav Spacek, Martin Sluka, Daniel Sanak, Zbynek Tudos, Dalibor Pastucha, Milos Taborsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):132-139 | DOI: 10.5507/bp.2023.050
In this prospective, unicentric, observational study, the prevalence and predictors of left ventricular thrombus (LVT) formation after acute myocardial infarction (AMI) were investigated. The study aimed to assess the role of transthoracic echocardiography, cardiovascular magnetic resonance and cardiac markers in predicting LVT and to determine the risk of systemic embolization to the central nervous system using brain MRA. In a cohort of seventy patients, the prevalence of LVT detected by TTE was 15.9% and by DE-CMR was 16.7%. LVT prevalence was particularly high in patients with anterior STEMI. However, there was no significant association between LVT detection and the occurrence of cardioembolic events. These findings provide valuable insights into the diagnosis, prediction, and potential risk factors of LVT following AMI.
Oxidative stress, microparticles, and E-selectin do not depend on HIV suppressionOriginal papers
Katerina Havlickova, Svatava Snopkova, Miroslav Pohanka, Radek Svacinka, David Vydrar, Petr Husa Jr., Jirina Zavrelova, Filip Zlamal, Lenka Fabianova, Miroslav Penka, Petr Husa
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):123-131 | DOI: 10.5507/bp.2024.002
High levels of oxidative stress, E-selectin, and microparticles are detected in HIV patients with and without ART. These abnormalities predisposed to the diseases associated with aging. There were no correlations between these biomarkers and viral suppression that is detected in peripheral blood. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is the key factor related to the premature aging of the immune system.
Fat embolism and COVID-19 infection: autopsy and post-mortem laboratory findings in SARS-CoV-2 positive patientsOriginal papers
Adriana Gavronova, Lukas Hamerlik, Margita Bartkova, Vaclav Svrchokryl, Veronika Kralikova, Katerina Vranova, Peter Ondra, Martin Dobias
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):116-122 | DOI: 10.5507/bp.2024.014
During the COVID-19 pandemic, patients often died abruptly under the picture of circulatory and respiratory failure. The cause of this sudden deterioration remained hidden even after their death due to initial low number of the autopsies of COVID-19 positive patients. Fat embolism is a commonly overlooked cause of circulatory and respiratory failure, but it does not normally accompany viral infections and is therefore not standardly considered in their treatment. The authors present one of the first studies to relate these mechanisms based on microscopic examination with special staining of the specimens, shedding new light on the treatment of severe conditions of SARS-CoV-2 infection.
Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinomaOriginal papers
Aneta Rozsypalova, Blanka Rosova, Alzbeta Filipova, Dimitar Hadzi Nikolov, Renata Chloupkova, Igor Richter, Roman Zachoval, Radoslav Matej, Bohuslav Melichar, Tomas Buchler, Josef Dvorak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):107-115 | DOI: 10.5507/bp.2024.005
The PD-L1, Smoothened protein and β-catenin expression were evaluated in 104 clear cell renal cell carcinoma patients (ccRCC). All studied tumor samples were acquired from nephrectomy specimens. An indirect immunohistochemistry was used. Median overall survival (OS) was significantly better in patients with lower PD-L1 expression (≤5%), Smoothened protein expression (<5%) or cytoplasmic β-catenin expression (≤75%) than in patients with higher expressions of these biomarkers (P<0.001, P=0.047, and P<0.001, respectively). Membranous β-catenin showed an opposite effect with its lower expression (≤75%) being associated with longer OS (P=0.020). The present study provides the first data on the potential association and combined prognostic significance of frequency of primary cilia, PD-L1, Smoothened protein and β- catenin expression with the outcome in ccRCC.
Two de novo UBR1 variants in trans as a cause of Johanson-Blizzard syndromeOriginal papers
Lukas Strych, Tomas Zavoral, Pavla Komrskova, Tomas Vanecek, Ivan Subrt
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):98-106 | DOI: 10.5507/bp.2025.005
The authors confirmed Johanson-Blizzard syndrome in a Czech proband by identification and characterization of two novel causal variants in the UBR1 gene (NM_174916.3), c.3482A>C and c.3509+6T>C. Using RNA and in silico analysis, they revealed that the splice site variant c.3509+6T>C induced the removal of a very rare non-canonical GC-AG intron and that the missense variant c.3482A>C altered a highly conserved zinc-coordinating histidine in the zinc-stabilized domain RING-H2. Although the variants were found in trans, neither was detected in the parents. To the best of their knowledge, the authors report the first molecular confirmation of JBS in the Czech Republic and the first identification of two de novo causal variants in two alleles.
Serum neurofilament light chain in response to probiotics in bi-center, double-blind, randomized, placebo-controlled clinical trial (CleverAge Biota)Original papers
Lenka Fialova, Ales Bartos, Marta Kalousova, Libuse Noskova, Miroslava Zelenkova, Michaela Slukova, Tomas Zima
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):91-97 | DOI: 10.5507/bp.2024.032
Brain function could be influenced by probiotics through gut microbiota. For the first time, the effect of probiotics was assessed by monitoring the concentrations of the neurodegeneration biomarker neurofilament light chains (NfL) in a well-defined group of community-dwelling individuals. A three-month intervention with original probiotics was not reflected in a reduction of serum NfL concentrations. Monitoring serum NfL concentrations did not show significant axonal degeneration at a three-month interval in community-dwelling elderly without probiotic intervention.
Meta-analysis study on anesthetic sedation recovery and onset times in pediatric and elderly patients undergoing CT and MRIReviews
Qiong Zhao, Fei Meng, Huimei Han, Lili Han
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):82-90 | DOI: 10.5507/bp.2024.034
This meta-analysis offers a comprehensive evaluation of anesthesia effectiveness, comparing dexmedetomidine and propofol, in pediatric and elderly patients undergoing CT and MRI procedures. It highlights original findings from a meta-analysis of 15 studies, demonstrating that anesthesia significantly improves patient compliance and reduces motion artifacts, thereby enhancing image quality. The study also underscores quicker sedation onset with dexmedetomidine but finds no notable differences in sedation duration between the drugs. Despite these promising results, the high heterogeneity in outcomes calls for further research to refine anesthesia strategies for optimal patient care
Adrenal insufficiency - causes and laboratory diagnosisReviews
Tomas Brutvan, Jana Jezkova, Marcela Kotasova, Michal Krsek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):73-81 | DOI: 10.5507/bp.2024.033
This article provides an overview of the causes of adrenocortical insufficiency, characteristic laboratory findings, and hormonal examinations including stimulation tests used in diagnostics. Attention is given to factors that may influence the results of hormonal examinations as well as to individual methods of laboratory determination. A special section within the article is dedicated to the use of plasma cortisol determination using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), drawing on our own experiences.
Study protocol - Prospective case-control trial - Impact of significant carotid stenosis on retinal perfusion measured with automated retinal oximetryOriginal papers
Petr Polidar, Barbora Paskova, Marta Karhanova, Martin Sin, Tomas Dornak, Zuzana Schreiberova, Petra Divisova, Tomas Veverka, David Franc, Daniel Sanak, Michal Kral
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):66-71 | DOI: 10.5507/bp.2023.052
The manuscript describes the protocol for a prospective study evaluating the relationship between carotid stenosis and retinal oxygen metabolism. Carotid stenosis is a major cause of ischaemic stroke worldwide. Retinal oximetry imaging of retinal blood vessels is noninvasive and capable of direct examination of the post-stenotic blood flow. It may be useful in differentiating high and low risk stenosis of the same severity. The results will yield more information about adaptive changes in the post-stenotic basin and may reveal mechanisms behind larger ischaemic deficits in some stroke patients. Previous studies have demonstrated that retinal blood flow is affected in a variety of eye and systemic diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma.
Comparison of toric intraocular lens tilt and decentration measurement using dynamic Purkinje-meter and anterior segment optical coherence tomographyOriginal papers
Eliska Palkovicova, Jiri Cendelin, Jiri Novak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):56-65 | DOI: 10.5507/bp.2024.017
The correct position of the intraocular lens and its stability in the capsular bag is crucial for the quality of the retinal image after cataract or refractive surgery. Although some tilt and decentration of the intraocular lens are common, greater extent of the tilt and decentration cause optical aberrations which have a negative impact on patients' visual comfort. The purpose of the article was to describe a new dynamic Purkinje-meter, an experimental method for intraocular lens position measurement based on the analysis of Purkinje images which could have a wider use than the existing static Purkinje-meters. The method was verified on a group of pseudophakic eyes: the values of decentration and tilt measured on the dynamic Purkinje-meter were comparable to those from commercially available anterior segment optical coherence tomography CASIA2.
Experimental model of primary intraocular lymphoma based on BALB/CaNn strain and A20 cells is optimal for investigational researchOriginal papers
Eva Skrlova, Eva Uherkova, Aneta Klimova, Diana Malarikova, Petra Svozilkova, Petr Matous, Vit Herynek, Tomas Kucera, Pavel Klener, Jarmila Heissigerova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):49-55 | DOI: 10.5507/bp.2024.003
The purpose of this project was to compare the characteristics of two experimental murine models of primary intraocular lymphoma (PIOL) and determine which experimental model is most suitable for further investigational research. PIOL was induced in immunocompetent mice with intravitreal injection of syngeneic B-cell lymphoma cell lines. Murine strain C3H/HeN and cell line 38C13 were used in the first model and BALB/CaNn mice and cell line A20 were used in the second model. During the experiments, thorough clinical and histological evaluations were carried out. PIOL in BALB/CaNn mice was less aggressive with slower progression which predisposes this strain to be more suitable for further research.
Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemiaOriginal papers
Sopiko Jashiashvili, Alla Zedginidze, Giorgi Ormotsadze, Asmat Shengelaia
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):44-48 | DOI: 10.5507/bp.2023.046
The aim of this investigation was to select markers of genetic instability and the genotoxicity of treatment for acute leukaemia, using the individual characteristics of patients to predict later complications. Eighty-six children with acute leukaemia were examined, on days 15 and 33, and the results were compared with clinical and laboratory data. The authors paid particular attention to the presence of polyploidy clones, where the modal number of chromosomes was associated with prognosis and dynamics of leukemic cells during the treatment and also focused on the level of micronuclei (Mn), one of the indicators of genetic instability. The authors examined Mn in buccal cavity cells since this is non-invasive and accessible.
Impaired intestinal permeability in patients with multiple sclerosisOriginal papers
Lenka Fialova, Pavla Barilly, Ivana Stetkarova, Ales Bartos, Libuse Noskova, Denisa Zimova, Michal Zido, Iva Hoffmanova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):37-43 | DOI: 10.5507/bp.2023.033
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system with a greater frequency in young adults. It has been speculated for some time, that an altered intestinal barrier is may be involved in the ethiopathogenesis of this disease, too. In our study we observed that the function of the intestinal epithelium can be impaired by increased permeability in patients with CIS and CDMS, however, no significant intestinal damage has been found. Based on the results CLDN-3 may play a role as potential biomarker of intestinal barrier disruption in patients with multiple sclerosis, mainly with treatment, but further contribution of CLDN3 from other compartments needs to be elucidated, e.g., the blood-cerebrospinal fluid barrier.
Results of surgical therapy of functioning pituitary adenomasOriginal papers
Vlastimil Novak, Lumir Hrabalek, Jan Schovanek, Zdenek Frysak, Racheal Temitope Ijisesan Perryova, Daniel Pohlodek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):32-36 | DOI: 10.5507/bp.2023.037
This study evaluates the results of surgical transnasal procedures in patients with functioning pituitary adenomas. The cohort consisted of 58 patients. Microadenoma was diagnosed in 58.6% and macroadenoma in 41.4%. In the group with excessive production of ACTH, complete remission was achieved after the first surgery in 78.6% of cases; in the group with excessive GH production in 51.4%. In the group with excessive production of PRL, it was 57.1%. Surgical therapy in the cohort described led to the normalisation of excessive hormone production in 58.6% of cases.
Clinical and molecular genetic analysis of cytologically uncertain thyroid nodules in patients with thyroid diseaseOriginal papers
Jindrich Lukas, Barbora Hintnausova, Vlasta Sykorova, Martin Syrucek, Marek Maly, David Lukas, Jaroslava Duskova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):26-31 | DOI: 10.5507/bp.2023.048
The study aimed to determine the preoperative clinical and molecular genetic risks of malignancy in indeterminate nodules (Bethesda III and IV) and their influence on the surgical treatment strategy of hemi/total thyroidectomy. Molecular tests were focused on the occurrence of pathogenic variants of somatic genes BRAF, RAS, TERT and rearrangements of RET/PTC, PAX8/PPARγ associated with thyroid oncogenesis. The incidence of clinical risk factors for malignancy was evaluated. The presence of at least one of these led to a significantly higher incidence of malignancy than in cases of their absence. From the experience of the authors so far, molecular genetic testing is one of the many decision-making factors in elective surgical procedures.
Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrenceOriginal papers
Martin Svaton, David Havel, Marcela Buresova, Jan Baxa, Petr Hosek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):21-25 | DOI: 10.5507/bp.2024.030
Percutaneous transthoracic needle biopsy of lung lesions is an alternative to bronchoscopic confirmation of lung lesions. The aim of this study was to assess the risk of pleural recurrence for all types of lung lesions. To the best of their knowledge, this has so far only been investigated in stage I lung tumors and not in all lung lesions. Secondary objectives included assessment of diagnostic yield and safety with respect to the incidence of pneumothorax and hemorrhage. In this study, percutaneous transthoracic needle biopsy of lung lesions showed high sensitivity and low degree of acute complications requiring an invasive solution. The risk of pleural recurrence after a biopsy was very low.
Evidence for preventing EVRB in cirrhotic patients: A systematic reviewReviews
Ye Liu, Xiaoyan Wang, Yingjia Gu, Dan Niu
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):9-20 | DOI: 10.5507/bp.2024.035
The authors included publications up to July 1, 2023. Five guidelines, 1 systematic review, and 2 expert consensuses were included. Twenty-four of the best levels were summarized. The evidence includes evaluation methods, risk management, preventive measures, health education and follow-up. This systematic review summarizes the latest evidence of the best level of EVRB prevention in liver cirrhosis. These are practical and can be used as reference for clinical and medical personnel.
Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkersReviews
Viktor Klementa, Nadezda Petejova, Pavel Horak, Ester Kurasova, Josef Zadrazil
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(1):1-8 | DOI: 10.5507/bp.2024.031
Acute kidney injury induced by gentamicin nephrotoxicity is a significant clinical concern due to the widespread use of gentamicin, an aminoglycoside antibiotic. Gentamicin can cause damage to renal tubular cells, leading to decreased kidney function. Emerging research highlights the role of specific microRNAs (miRNAs) as potential biomarkers for early detection and monitoring of gentamicin-induced nephrotoxicity. These miRNAs are small, non-coding RNA molecules involved in regulating gene expression, and their altered levels in the blood or urine can indicate kidney damage before traditional markers, such as serum creatinine. Identifying these miRNAs could improve diagnosis, enable timely intervention, and potentially mitigate the adverse effects of gentamicin on renal health.
Postcovid Guillain-Barré syndrome with severe course - case series two patients including clinical evaluation of smell and examination of olfactory event-related potentials (OERPs)Case report
Nikola Pastorkova, Karla Janouskova, Libor Vasina, Helene Schulz, Jaromir Astl, Richard Holy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):354-358 | DOI: 10.5507/bp.2023.014
This work presents case reports of two patients with Guillain-Barré syndrome associated with previous COVID19 that both patients survived. The sense of smell was investigated subjectively using sniffin' stick tests and objectively using objective olfactometry by the evaluation of olfactory event-related potentials (OERPs). Despite the severe course of post-covid GBS, no olfactory disturbance was detected. Both patients had good results on the smell tests. OERPs were plentiful in both cases.
Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center studyOriginal papers
Matej Halaj, Ondrej Kalita, Lucie Tuckova, Lumir Hrabalek, Martin Dolezel, Jana Vrbkova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):349-353 | DOI: 10.5507/bp.2023.030
Progress in the of diagnostic and neurosurgical techniques of the last decade have enabled even safe resection of suspected GBMs located in eloquent brain regions. Currently, patients indicated for only the needle biopsy represent a minority group with a common poor prognosis. The purpose of stereotactic biopsy is to obviate misdiagnosis and to choose the optimal treatment strategy. The aim of this paper is to evaluate life expectancy in patients with GBM confirmed by needle biopsy and the relationship with the following oncotherapy. Patients in this study who had undergone oncotherapy, had a slight increase in overall survival. The effect of this treatment was enhanced in patients with favourable clinical factors such as age and Karnofsky score.
Occult fractures detected on radiographs in young children with a concern for abusive head traumaOriginal papers
Eliska Popelova, Zuzana Holubova, Marcela Dvorakova, Martin Kyncl
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):342-348 | DOI: 10.5507/bp.2023.018
Identifying infants and toddlers with abusive head trauma is challenging. Finding any evidence of trauma in these children is therefore very important. Dedicated skeletal radiographs of the whole skeleton should be performed in all children younger than two years evaluated for possible abuse. Our study showed that dedicated skeletal radiographs were only performed in 62% of children younger than two years evaluated for suspected abusive head trauma. Clinically occult fractures were revealed in 31% of these children. Moreover, the majority of these fractures had high specificity for abuse. Attention should be paid to increasing awareness of child abuse imaging protocols.
The association between preterm births and assisted reproductive technologiesOriginal papers
Anna Stastna, Eva Waldaufova, Tomas Fait
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):332-341 | DOI: 10.5507/bp.2023.039
While assisted reproductive technology (ART) offers hope to millions of couples worldwide in overcoming infertility, it also attracts attention to investigating the health outcomes of mothers and their children. Using Cox regression models, this study compares preterm birth risk between ART-assisted singleton pregnancies (in-vitro fertilisation (IVF) with fresh embryo transfer, frozen embryo transfer (FET) and oocyte receipt (OoR)) with non-ART singleton pregnancies. The results show a higher preterm birth risk in ART-treated women (1.56 to 2.06 depending on the ART method) compared to women without ART treatment. However, no statistically significant differences were found in the risk of preterm birth among ART-treated mothers based on specific ART methods.
Fetal magnetic resonance imaging in the confirmation of congenital anomalies found on routine mid-trimester ultrasoundOriginal papers
Ishraq Dhaifalah, Marek Godava, Jana Havalova, Pavla Hanzlikova, Kamila Michalkova, Lenka Bakaj Zbrozkova, Jakub Civrny, Howard Cuckle
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):326-331 | DOI: 10.5507/bp.2024.008
Most pregnant women are offered a routine ultrasound scan during the second trimester of pregnancy in order to detect fetal anomalies. In some cases, an anomaly suspected by ultrasound requires referral for a fetal magnetic resonance imaging (MRI) examination in order to clarify the diagnosis. In this study a large series of such referrals was assessed, accounting for one in six women with a fetal anomaly on ultrasound. In general, the MRI findings supported the scan results but this varied according to the type of anomaly. This concordance was very high for anomalies of the urinary tract and face.
Gamma-glutamyltransferase-associated glycoprotein patterns in human seminal plasma of normozoospermic men: a new aspect of biomarker heterogeneityOriginal papers
Tamara Jankovic, Jelena Danilovic Lukovic, Sanja Goc, Ninoslav Mitic, Ljiljana Hajdukovic, Miroslava Jankovic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):319-325 | DOI: 10.5507/bp.2023.031
Gamma-glutamyltransferase (GGT) is implicated in a variety of diseases, but it is not extensively studied in relation to reproductive physiology. An increase in GGT activity is associated with alterations in a specific fractional pattern of distinct molecular mass forms. In this study, seminal GGT forms were estimated and, for the first time, annotated with underlying patterns of sialylated and mannosylated glycoproteins. The GGT-associated glycoprotein patterns were established as an adjunct reference parameter to differentiate between known GGT molecular mass forms. These emerge as new targets for evaluation of its biomarker potential.
The renoprotective effect of Tibolone in sepsis-induced acute kidney injuryOriginal papers
Ejder Saylav Bora, Duygu Burcu Arda, Oytun Erbas
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):311-318 | DOI: 10.5507/bp.2024.016
This study breaks new ground by investigating Tibolone’s potential as a therapeutic agent in sepsis-induced acute kidney injury (AKI), an area largely unexplored previously. By delving into Tibolone’s effects on biomarkers like SIRT1 and YAP, as well as its impact on inflammatory and oxidative processes, it sheds light on its promising role in mitigating renal damage. The findings underscore Tibolone’s potential as a novel intervention for sepsis-associated AKI, urging further research for translational application in clinical settings.
Comparison of dose length product and image quality of a biphasic whole-body polytrauma CT protocol with and without the automatic tube voltage selectionOriginal papers
David Girsa, Karin Kremenova, Jiri Lukavsky, Lucie Sukupova, Hana Malikova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):304-310 | DOI: 10.5507/bp.2024.004
This work has shown that in terms of reducing the radiation load of the two-phase whole-body CT protocol used in the examination of polytraumatic patients, there is no difference whether we use only the function of automatic current modulation on the X-ray tube, or its combination with the function of automatic voltage selection. In the case of a combination of both functions, the image quality drops slightly. Significantly more important for the radiation load is the position of the patient's arms during the examination: if the arms are in the scanned volume along the body, the radiation load is significantly higher in both examined groups.
Safety and efficacy of simple training protocol in patients after mild traumatic brain injuryOriginal papers
Martina Martinikova, Robert Ruzinak, Petra Hnilicova, Michal Bittsansky, Marian Grendar, Lucia Babalova, Pavol Skacik, Ema Kantorova, Vladimir Nosal, Monika Turcanova Koprusakova, Jozef Sivak, Jana Sivakova, Zuzana Biringerova, Branislav Kolarovszki, Kamil Zelenak, Egon Kurca, Stefan Sivak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):295-303 | DOI: 10.5507/bp.2023.013
In this paper, the authors show that simple physical and cognitive training after mild traumatic brain injury (mTBI) can be positive for the brain and its functions and help in the prevention of post-concussion syndrome. This can lead to the decreased economic burden of mTBI, and individual training can be performed without professional supervision.
S100B protein as a biomarker and predictor in traumatic brain injuryOriginal papers
Stefan Trnka, Premysl Stejskal, Jakub Jablonsky, David Krahulik, Daniel Pohlodek, Lumir Hrabalek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):288-294 | DOI: 10.5507/bp.2023.025
Despite the known value of using S100B protein for its prognostic potential in cases of traumatic brain injury, the findings of this study are that the correlations between selected internal diseases, body habitus, season and S100B protein are not confirmed in TBI patients. Conversely, when interpreting the results of patients with polytrauma, it is important to remember that the S100B protein value is modified in this instance. A benefit that cannot be overlooked is that the S100B values are associated with good patient prognosis, offering therapeutic advantages in addition to the prognostic ones.