Biomedical papers, 2017 (vol. 161), issue 3


Pulse wave analysis and diabetes mellitus. A systematic review

Jaromira Gajdova, David Karasek, Dominika Goldmannova, Ondrej Krystynik, Jan Schovanek, Helena Vaverkova, Josef Zadrazil

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):223-233 | 10.5507/bp.2017.028

Arterial stiffness assessment by pulse wave analysis is regarded as a predictive factor of cardio vascular (CV) events. Arterial stiffness is increased in patients with diabetes mellitus.who have increased risk of CV disorders. The aim of this paper was to review current knowledge of the relationship between diabetes mellitus and pulse wave analysis.

Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatment

Martin Cernan, Tomas Szotkowski, Zuzana Pikalova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):234-241 | 10.5507/bp.2017.013

Mixed-phenotype acute leukemia (MPAL) is a rare disease with a poor prognosis. This review article evaluates the relevant literature and summarizes current knowledge and treatment of MPAL.

Compartment syndrome and regional anaesthesia: Critical review

Jozef Klucka, Petr Stourac, Alena Stouracova, Michal Masek, Martin Repko

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):242-251 | 10.5507/bp.2017.025

Acute compartment syndrome (ACS) in traumatology and orthopaedic surgery requires urgent diagnosis and treatment. Currently, it is not clear, whether functional regional anaesthesia and analgesia can lead to delay in diagnosis and treatment of ACS. In this systematic review, the authors evaluate the actual evidence-based data on regional anaesthesia/analgesia in high-risk patients with possible ACS.

Original papers

Heterogeneity of molecular forms of dipeptidyl peptidase-IV and fibroblast activation protein in human glioblastomas

Ivana Matrasova, Petr Busek, Eva Balaziova, Aleksi Sedo

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):252-260 | 10.5507/bp.2017.010

Using enzymatic and immunochemical methods, the authors describe for the first time DPP-IV and FAP in various isoforms in high grade gliomas with a varying pattern in individual tumors. The molecular heterogeneity of both enzymes is most probably not due to differential glycosylation.

Transcriptome analysis reveals distinct gene expression profiles in astrocytoma grades II-IV

Nato Narsia, Pradeep Ramagiri, Jiri Ehrmann, Zdenek Kolar

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):261-271 | 10.5507/bp.2017.020

Using a large cohort of publically available RNA sequencing data for astrocytoma grades II-IV and normal brain samples, the authors analyzed gene expression profiles to identify key genes, regulatory network and signaling pathways. They also identified both unique and common characteristics of astrocytoma grades II-IV.

Circulating tumor cells and serum levels of MMP-2, MMP-9 and VEGF as markers of the metastatic process in patients with high risk of metastatic progression

Marketa Skerenova, Veronika Mikulova, Otakar Capoun, Tomas Zima, Petra Tesarova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):272-280 | 10.5507/bp.2017.022

Circulating tumor cells are confirmed as a promising prognostic marker in metastatic cancer patients. A predictive potential of matrix metalloproteinase 2 serum level for brain metastases development in HER2 positive breast cancer patients was also found.

Are goblet cell carcinoids a group of heterogeneous tumors?

Jirka Macak, Kristina Nemejcova, Jana Dvorackova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):281-285 | 10.5507/bp.2017.027

In the WHO classification, goblet cell carcinoids are neuroendocrine tumors; they react positively to neuroendocrine markers. However, some tumors having the same histological appearance do not react with these markers and their Ki-67 proliferative index is as high as that in adenocarcinomas. It is the opinion of the authors that these tumors should not be classified as goblet cell carcinoids.

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Lenka Fialova, Ales Bartos, Jana Svarcova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):286-295 | 10.5507/bp.2017.038

CSF tau proteins and their index, differentiated Alzheimer's disease patients from other dementias and cognitively normal elderly subjects.CSF levels of neurofilaments expressed as their index discriminated between patients with neuroinflammation and Alzheimer's disease patients and cognitively normal controls.

Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage

Martina Skacelova, Zuzana Hermanova, Pavel Horak, Ahmed Kazi, Katerina Langova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):296-302 | 10.5507/bp.2017.015

This study evaluated the serum levels of matrix metalloproteinase-3 (MMP-3) in the context of rheumatoid arthritis (RA) and osteoarthritis (OA). The results were correlated with clinical activity, antibody profile and X ray findings. Levels of MMP-3 were statistically significant higher in RA patients than in healthy controls and OA patients and correlated with disease activity, antibody profile and radiographic disease stage. MMP-3 could become a novel marker of RA activity.

Possibilities for modifying risk factors for the development of hospital-acquired pneumonia in intensive care patients: results of a retrospective, observational study

Radovan Uvizl, Milan Kolar, Tomas Herkel, Michaela Vobrova, Katerina Langova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):303-309 | 10.5507/bp.2017.019

Presented are single-center, retrospective data from a 5-year study of the epidemiology of hospital acquired pneumonia (HAP) in intensive care patients. The sample was divided into f patients who developed early- or late-onset HAP and those who did not. The frequency of modifiable and non-modifiable risk factors vis á vis the development of HAP was assessed. The most important non-modifiable factors were multiple organ failure, cardiac disease and chronic renal failure. The most common modifiable factors were intolerance of enteral nutrition, urgent tracheal intubation, reintubation and bronchoscopy. Stress ulcer prophylaxis was administered to 83% of HAP patients and 68% of patients without HAP. Prophylaxis with famotidine was associated with a lower risk than pentoprazole prophylaxis.

Excellent AUC for joint fluid cytology in the detection/exclusion of hip and knee prosthetic joint infection

Jiri Gallo, Jarmila Juranova, Michal Svoboda, Jana Zapletalova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):310-319 | 10.5507/bp.2017.021

This paper provides evidence supporting the use of the synovial white cell count as well as neutrophil and lymphocyte percentages in the diagnostic workup for prosthetic joint infection.

Shear wave elastography parameters of normal soft tissues of the neck

Jan Herman, Zuzana Sedlackova, Jaromir Vachutka, Tomas Furst, Richard Salzman, Jaroslav Vomacka

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):320-325 | 10.5507/bp.2017.024

This very first study of tissue stiffness of thyroid, submandibular and parotid glands, masseter and sternocleidomastoid muscles, and cervical lymph nodes in kPa concluded their relatively narrow distribution (around 11 kPa) in healthy individuals. The sex, age and BMI showed statistically significant, however clinically insignificant, impact. Interestingly, systematically lower stiffness was demonstrated in all left-sided organs.

Case report

Single giant mediastinal rhabdomyoma as a sole manifestation of TSC in foetus

Marek Godava, Hana Filipova, Lubomir Dubrava, Radek Vrtel, Kamila Michalkova, Maria Janikova, Lenka Bakaj-Zbrozkova, Jiri Navratil

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):326-329 | 10.5507/bp.2017.023

Single huge progressive cardiac rhabdomyoma in fetus is associated with a novel TSC2 variant in a family without any previous history of tuberous sclerosis.

Letter to the editor

Comment on: “A patient called Medical Research” by T. Furst and J. Strojil. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017,161(1):54-7. doi:10.5507/bp.2017.005

Norbert Cibicek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(3):230-231