Biomedical papers, 2020 (vol. 164), issue 4
Reviews
Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society
Jaromir Zatloukal, Kristian Brat, Katerina Neumannova, Eva Volakova, Karel Hejduk, Eva Kocova, Ondrej Kudela, Michal Kopecky, Marek Plutinsky, Vladimir Koblizek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):325-356 | DOI: 10.5507/bp.2020.056 
This document represents the opinions and recommendations of the expert group commissioned by the Czech Pneumological and Phthisiological Society regarding diagnosis, management and treatment of Chronic Obstructive Pulmonary Disease. This position paper builds upon the previous version of 2013 and on recent scientific knowledge. The recommendations made in this document incorporate data from both randomized clinical trials and real-life studies. The paper is based on clinical phenotypes of COPD and employs the treatable traits concept for COPD treatment. It does not contradict the GOLD reports and refers to their basic concepts. However, the recommendations made in this paper more precisely reflect the heterogeneity of COPD and are more detailed, patient-centered and personalized.
Types of congenital nonsyndromic ichthyoses
Blanka Pinkova, Hana Buckova, Romana Borska, Lenka Fajkusova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):357-365 | DOI: 10.5507/bp.2020.050
Congenital ichthyoses are a very heterogeneous group of more than 20 diseases manifested by very dry, rough and scaling skin. They belong into a group of rare diseases - keratodermies. The heredity is generally autosomal dominant or X-linked recessive but autosomal recessive (AR). Currently, the diagnosis of congenital ichthyoses is based on molecular analysis, which also allows complete genetic counseling and genetic prevention. With the molecular analysis of DNA, pathogenic mutations can be identified and a prognosis of the ichthyosis can be made.
Use of high-density EEG in patients with Parkinson's disease treated with deep brain stimulation
Jiri Buril, Petra Burilova, Andrea Pokorna, Marek Balaz
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):366-370 | DOI: 10.5507/bp.2020.042
This is a literature review focused on the use of high-density EEG in patients with Parkinson's disease. Scientific articles were systematically searched using the PubMed, Scopus and Web of Science databases. The records identified by the search confirm that high-density EEG may be used as a feasible research tool in patients with Parkinson's disease treated with deep brain stimulation.
Modulation of the human sensorimotor system by afferent somatosensory input: evidence from experimental pressure stimulation and physiotherapy
Pavel Hok, Petr Hlustik
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):371-379 | DOI: 10.5507/bp.2020.052
In this review, the authors have assembled the literature on neurophysiological and functional imaging sequelae of mechanical pressure stimulation motivated by its clinical applications, including reflex locomotion therapy. The authors highlight the limited amount of research devoted to this stimulus modality, emphasise current knowledge gaps, present recent developments in the field and highlight the evidence awaiting replication or confirmation in future neuroimaging studies.
Original papers
Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target
Jiaxiao Shi, Peng Peng, Weixiao Liu, Peng Mi, Cong Xing, Guangzhi Ning, Shiqing Feng
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):380-386 | DOI: 10.5507/bp.2019.049
The CD2 may be a new therapeutic target for the patchy-type alopecia areata.
Comparison of atrial fibrillation ablation efficacy using remote magnetic navigation vs. manual navigation with contact-force control
Jiri Jez, Tomasz Jadczyk, Frantisek Lehar, Martin Pesl, Tomas Kulik, Silvie Belaskova, Filip Soucek, Guido Caluori, Wojciech Wojakowski, Zdenek Starek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):387-393 | DOI: 10.5507/bp.2019.045
Remote magnetic navigation is a safe and effective method for invasive treatment of atrial fibrillation. However, the standard manual approach is more favorable in terms of procedural and ablation time.
Prediction Score for persisting perfusion defects after pulmonary embolism
Jan Mrozek, Tereza Necasova, Michal Svoboda, Iveta Simkova, Pavel Jansa
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):394-400 | DOI: 10.5507/bp.2019.033
In this study, the authors derived a risk score for prediction of persistence of perfusion defects after pulmonary embolism (PE). Based on a long-term follow up of 83 patients after PE, three risk groups were identified according to the level of hemoglobin and age at the time of PE.
Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
Veronika Matuskova, Pavla Hornackova, Radoslava Uhmannova, Lenka Zlamalikova, Kvetoslava Liskova, Michal Uher, Eva Vlkova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):401-409 | DOI: 10.5507/bp.2019.037
Chromosomal abnormalities of the melanoma can accurately predict the risk of metastases in affected patients. Testing is routinely carried out in oncology care in the United States and in some European states. These are the first results from the Czech population.
Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study
Petra Svozilkova, Eva Rihova, Michaela Brichova, Andrea Havlikova, Aneta Klimova, Jarmila Heissigerova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):410-416 | DOI: 10.5507/bp.2019.036
Infectious uveitis is one possible complication in immunodeficient patients. The occurrence of cytomegaloviral retinitis is life-threatening complication in patients who have had hematopoietic stem cell transplantation. Patients with herpetic retinopathies have a poor visual prognosis.
Effects of dexmedetomidine versus remifentanil on mothers and neonates during cesarean section under general anesthesia
Zhiqiang Yu, Peijun Zhang, Haiyun Wang, Li Zhang, Wei Wei, Wenqian Fang, Xingbo Mu
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):417-424 | DOI: 10.5507/bp.2019.055
There is no ideal agent for obstetric general anesthesia. In this study, remifentanil demonstrated better control of maternal hemodynamic stability, while dexmedetomidine demonstrated better neonatal Apgar scores, maternal postoperative analgesia, and decreased maternal catecholamine release. The results offer novel insights into improving anesthetic management of mothers and neonates during cesarean section under general anesthesia.
Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study
Kamila Stranska, Karla Plevova, Hana Skuhrova Francova, Hana Skabrahova, Magdalena von Jagwitz-Biegnitz, Lenka Radova, Anna Panovska, Stanislava Hrobkova, Yvona Brychtova, Renata Urbanova, Lukas Smolej, Martin Simkovic, Jana Zuchnicka, Lekaa Mohammadova, Martin Spacek, Jiri Mayer, Sarka Pospisilova, Michael Doubek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):425-434 | DOI: 10.5507/bp.2019.046
This study is the first to investigate chronic lymphocytic leukemia (CLL) immunogenetic features and clonality in the context of epidemiological data. The authors report potential associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic B cell receptor features, especially stereotypy.
Percutaneous biopsy of retroperitoneal lesions - 10 year experience of a single centre
Petr Dvorak, Petr Hoffmann, Michal Balik, Martina Hoffmannova, Jindrich Kopecky, Radka Dvorakova, Marketa Nova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):435-443 | DOI: 10.5507/bp.2019.028
Retroperitoneal tumors are relatively common, the impairment spectrum is broad, and safe establishment of correct diagnosis is crucial for the planning of further therapies. CT-guided biopsy using a percutaneous approach is a suitable interventional method with comparable diagnostic accuracy to surgical excision, but significantly less invasive.
Assessment of visual sensation, psychiatric profile and quality of life following vestibular schwannoma surgery in patients prehabituated by chemical vestibular ablation
Zuzana Balatkova, Zdenek Cada, Silvie Hruba, Martin Komarc, Rudolf Cerny
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):444-453 | DOI: 10.5507/bp.2019.056
This study evaluates the relationship between the self-reported psychological profile of patients and/or the presence of preoperatively induced chemical labyrinthectomy on their postoperative perception of optokinetic stimulation (optic flow) and quality of life. In many cases, increased sensitivity to optic flow leads to a decrease in quality of life in relation to performing common daily activities. Therefore, understanding the nature of this phenomenon would certainly help to increase compensation speed in both the vestibular and oculomotor systems.
Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial
Radana Dymackova, Tomas Kazda, Marek Slavik, Iveta Selingerova, Pavel Slampa, Ondrej Slama
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):454-460 | DOI: 10.5507/bp.2020.021
This was a prospective randomized open-label single institutional trial conducted to evaluate the role of acupuncture in the treatment of the toxicity of chemo/radiotherapy in patients with head and neck tumors. The pilot results show that patients with acupuncture had less toxicity (skin, mucosal, pain). Description and validation of effects of acupuncture using scientific approaches will increase acceptance of acupuncture by both patients and health care providers.
Audio-visual navigation reduces treatment time in deep-inspiration breath hold radiotherapy
Martin Dolezel, Karel Odrazka, Jaroslav Vanasek, Igor Hartmann, Tereza Kohlova, Zuzana Vlachova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):461-466 | DOI: 10.5507/bp.2019.051
Radiation therapy is rapidly evolving and modern techniques such as deep-inspiration breath hold and stereotactic radiotherapy are often time consuming. This is the first study investigating the time factor associated with different forms of DIBH. The authors show that audio-visual navigation significantly reduces the treatment time.