Biomedical papers, 2023 (vol. 167), issue 4
Reviews
The contribution of new methods in cytology for increasing sensitivity in the diagnosis of extrahepatic bile duct lesions
Daniela Kurfurstova, Zuzana Slobodova, Vincent Zoundjiekpon, Ondrej Urban
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):309-318 | DOI: 10.5507/bp.2023.041 
This is a review of current and new methods for improving on the sensitivity of biliary stenoses examinations, especially in relation to suspected carcinoma. Included are fluorescence in situ hybridization, next generation sequencing, the immunocolorimetric ELISA test, methylation markers of DNA and liquid. biopsy.
Current status and future perspectives of oral HPV testing in the diagnosis and monitoring of oropharyngeal cancer. A review
Zuzana Horákova, Ivo Starek, Richard Salzman
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):319-327 | DOI: 10.5507/bp.2023.040
HPV16 status in oropharyngeal cancer (OPC) is an important prognostic factor. As its determination, based on immunistochemical analysis of p16 oncoprotein requires invasive biopsy, determining oral HPV16 status may be a promising alternative. With an average sensitivity and specificity of 74% and 91% resp. oral sampling appears to be valuable in monitoring treatment response, enabling early detection of persistent or relapsing carcinoma sufficiently long before its clinical and/or radiological manifestation. It may also contribute to identification of the primary tumour in cases of metastases of unknown origin. The screening could identify individuals who are at increased risk of developing OPC.
Overweight and obesity in children and adolescents with endocrine disorders
Renata Pomahacova, Petra Paterova, Eva Nykodymova, Petr Polak, Eva Sladkova, Eva Skalicka, Josef Sykora
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):328-334 | DOI: 10.5507/bp.2023.036
This article describes endocrine disorders which may play a role in the etiology of obesity in childhood. Though these are uncommon in overweight and obese children, late diagnosis may be associated with high morbidity or rarely, mortality. The authors describe the pathophysiological mechanisms responsible for the development of some forms of obesity in childhood and related clinical, diagnostic and management issues including factors such as growth patterns and BMI charts leading to the diagnosis of these conditions. Timely diagnosis of endocrinopathy and prompt treatment are necessary.
Original papers
CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC)
Marie Drosslerova, Martina Sterclova, Alice Taskova, Vladislav Hytych, Eva Richterova, Magdalena Bruzova, Miloslav Spunda, Martin Komarc, Martina Koziar Vasakova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):335-339 | DOI: 10.5507/bp.2022.050
Lung cancer is the most common type of cancer in the world. It is unclear whether the concentrations of chemokines at the time of NSCLC (non-small cell lung cancer) diagnosis differ from healthy controls and reflect the extent of NSCLC. This study focuses on chemokine concentrations in the plasma of patients with resectable NSCLC vs healthy individuals and chemokine concentrations according to stage of NSCLC.
Long-term outcomes of bipolar transurethral enucleation and resection of the prostate on patients with benign prostatic obstruction: a 10-year follow-up
Peijie Chen, Peng Xu, Chunxiao Liu
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):340-346 | DOI: 10.5507/bp.2022.034
This 10-year follow-up indicates that B-TUERP is a safe and highly effective treatment for symptomatic BPH with lower reoperation rates. UDS value plays an important role in the preoperative judgment of surgical indications and the prediction of postoperative effect. Age, OABSS, PSA, MCC and DO may be critical predictors for urge incontinence after B-TUERP.
Evaluation of aortic stiffness by echocardiography in tympanosclerosis patients
Hikmet Hamur, Oruc Alper Onk, Resit Coskun, Muharrem Said Cosgun, Ismail Salcan, Izzet Emir
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):347-351 | DOI: 10.5507/bp.2022.031
Aortic stiffness is a well-known predictor for developing atherosclerosis. Similar pathophysiological processes based on inflammation may explain aortic stiffness and tympanosclerosis formation. In this study, aortic stiffness parameters and blood inflammatory parameters were impaired in tympanosclerosis-detected patients.
The role of abdominal ultrasonography in patients with isoattenuating pancreatic carcinoma
Robert Psar, Ondrej Urban, Tomas Rohan, Michal Stepan, Martin Hill, Marie Cerna
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):352-356 | DOI: 10.5507/bp.2022.032
Abdominal ultrasonography can detect secondary signs of isoattenuating pancreatic tumours with high sensitivity (88%) and has the potential to directly visualise these tumours in 21%. In this study, endoscopic ultrasonography detected a dilated pancreatic duct in isoattenuating pancreatic cancers significantly more often than abdominal ultrasonography.
Assessment of defecation disorders using high-resolution MRI-defecography
Ioana Duca, Ramona Boja, Dan Lucian Dumitrascu
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):357-361 | DOI: 10.5507/bp.2022.023
As clinical examination is inadequate in functional defecation disorders, and many multiparous women are at risk for outlet obstruction constipation, our diagnostic approach emphasizes the importance of correlating dynamic MRI-defecography, anorectal manometry and psychiatric disorders. Hypertonic anal sphincter and lack of defecation reflex at anorectal manometry correlated with anismus in all patients at MRI-defecography. Many cases with terminal constipation and anismus had a good correlation between defecation dysfunction and MRI-defecography pattern and it was also often associated with anxiety-depressive disorders.
Thoracoscopic epicardial ablation of atrial fibrillation: Safety, efficacy, single center experience
Martin Troubil, Martin Simek, Jan Juchelka, Andrea Steriovsky, Roman Hajek, Petr Santavy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):362-365 | DOI: 10.5507/bp.2022.041
An observational study evaluating the safety and efficacy of thoracoscopic ablation of atrial fibrillation in the single-center experience. The cohort consisted of 81 patients suffering from some form of atrial fibrillation, undergoing thoracoscopic ablation either as a single method of treatment or as a part of the hybrid protocol where catheter ablation was suplemented later.
Pars plana vitrectomy for vitreoretinal interface disorders coincident with intermediate stage age-related macular degeneration
Anna Tarkova, Libor Hejsek, Tomas Jurecka, Petra Wolkova, Martina Rubesova, Michal Hackl
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):366-369 | DOI: 10.5507/bp.2022.047
Vitreoretinal surgery for vitreoretinal disorders has similar anatomical results whether or not the outer retina is damaged by intermediate AMD. Functional results are naturally affected by the eventual disruption of the retinal pigment epithelium or photoreceptors by an age-related process. The vitreoretinal surgery has a standard security profile. It is safe and does not affect the progression of AMD in the short term.
Three-year follow-up results of two children born from a transplanted uterus
Jan Janota, Ekaterina Orlova, Marta Novackova, Roman Chmel Jr., Radim Brabec, Zlatko Pastor, Roman Chmel
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):370-375 | DOI: 10.5507/bp.2023.042
Uterus transplantation appears to be a perspective treatment modality of absolute uterine factor infertility but it is still at an experimental stage worldwide. In this article, observational data on pregnancy outcomes, neonatal course, growth trajectory and 3-year follow-up in two children born at our institution in 2019 to mothers after uterus transplantation were analyzed, including assessment of neurodevelopment using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). No abnormalities were observed in either prematurely born babies in terms of the neonatal course and 3-year follow-up, including the neurodevelopmental status. This is the first ever report on neurodevelopmental outcomes in children born after uterus transplantation.
Case reports
Hyperprogression on anti-PD-1 treatment. Is subsequent therapy feasible? A case report and review of the literature
Jan Skacel, Bohuslav Melichar, Beatrice Mohelnikova-Duchonova, Radmila Lemstrova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):376-384 | DOI: 10.5507/bp.2022.025
Hyperprogression is a new phenomenon that has emerged with the advent of immune checkpoint inhibitors. Prompt recognition and change of the treatment management is crucial. Chemotherapy based on taxanes is a reasonable option after hyperprogression. Hyperprogression is rarely observed with anti-CTLA-4 treatment.
Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report
Dominika Ecsiova, Katerina Kamaradova, Marketa Nova, Petr Hoffmann, Petra Rozsivalova, Martin Simkovic, Pavel Zak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):385-389 | DOI: 10.5507/bp.2022.026
This case report describes the management of treatment of HCL in a 53-year-old woman who developed a rare lung condition as part of the activity of the hematological disease. The authors present the differential diagnosis of pulmonary disease in patients with HCL and the treatment approach in these patients.
Comprehensive home-based telerehabilitation in a morbidly obese male patient with severe obstructive sleep apnea. A case report
Jakub Hnatiak, Lujza Zikmund Galkova, Petr Winnige, Ladislav Batalik, Filip Dosbaba, Ondrej Ludka, Jan Krejci
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(4):390-394 | DOI: 10.5507/bp.2023.022
OSA is the most common of sleep-related breathing disorders in males. It adversely affects not only the patient's sleep quality, but their overall QoL as well. Even though CPAP therapy represents the standard treatment for moderate to severe OSA, rehabilitation should be considered as an additional therapy to further alleviate OSA symptoms. In this case report we show significant improvement of severe OSA in a male patient after the completion of the novel 12-week, comprehensive tele-RHB program. Our findings suggest that this tele-RHB program may be a novel home-based treatment to be used in conjunction with CPAP therapy.
This issue was published with support of Novartis, Roche and Janssen-Cilag s.r.o. companies
