Biomedical papers, 2022 (vol. 166), issue 1
Reviews
Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review
Kristyna Mezerova, Vladislav Raclavsky, Lubomir Stary
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):1-11 | DOI: 10.5507/bp.2021.054 
Non-invasive screening for colorectal cancer relies on fecal occult blood testing which can detect up to 80% of asymptomatic cases. Besides strategies that depend on detection of tumor-specific genetic material, cancer-associated microbiota are another source of markers capable of reducing the ≥20% false negative rate of the current screening. In this review, we assess the potential of toxigenic gram-negative bacteria as such markers and recommend those best suited for clinical trials.
Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents
Faiha M. Al-Ardhi, Ladislav Novotny, Adel Alhunayan, Naser F. Al-Tannak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):12-20 | DOI: 10.5507/bp.2021.063
Antimetabolites remdesivir and favipiravir were repurposed as treatment options for Covid-19. Both drugs possess antiviral properties by mimicking purine RNA constituents but the detailed processes of their antimetabolite actions differ, making these molecules unique in their mechanisms of anti-Covid-19 action. This article compares the chemical and pharmacological proprieties of these drugs in addition to their role as anti-Covid 19 agents based on data obtained from clinical trials.
Lesions in the oral cavity and esophagus caused by prescribed drugs: A review
Snezana Tesic-Rajkovic, Biljana Radovanovic-Dinic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):21-27 | DOI: 10.5507/bp.2021.059
Adverse effects of certain drugs on the oral cavity and esophagus can induce injury that may significantly impact further treatment and quality of life. If these are not timely recognized, complications are possible, resulting in unnecessary diagnostic procedures and inadequate treatment attempts.
Periodontitis association with IL-8 gene polymorphisms
Albertas Kriauciunas, Gediminas Zekonis, Rasa Liutkeviciene
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):28-39 | DOI: 10.5507/bp.2021.066
In this article, the authors report on IL-8 polymorphisms and their association with periodontitis. Various studies analyse different polymorphisms and their association with periodontitis, but conflicting results regarding the disease relation to IL-8 polymorphisms are being apprised. In this paper, the focus is on the genetic aspect of periodontitis.
Original papers
Analgesic effects of piritramide in acute postoperative pain - comparison of intramuscular administration with patient-controlled intravenous analgesia and impact of OPRM1 and ABCB1 polymorphisms
Olga Bartosova, Martin Sima, Ondrej Polanecky, Frantisek Perlik, Svatopluk Adamek, Robert Lischke, Ondrej Slanar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):40-45 | DOI: 10.5507/bp.2020.053
Patient-controlled intravenous analgesia with piritramide is associated with higher opioid consumption, leads to better pain relief with slightly worse safety profile in comparison with intramuscular application. Variant OPRM1 118G allele is associated with decreased pain relief after piritramide.
Postoperative pain and analgesic consumption after endoscopic and microscopic ear procedures
Richard Salzman, Tomas Bakaj, Ivo Starek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):46-50 | DOI: 10.5507/bp.2021.006
Endoscopic ear surgery is associated with less postoperative pain and smaller consumption of painkillers than the conventional microscopic ear surgery. It is rather the transmeatal approach, and not the endoscope itself that reduces postoperative pain.
Aortic propagation velocity in the prediction of coronary artery disease severity
Eftal Murat Bakirci, Husnu Degirmenci, Hakan Duman, Selami Demirelli, Hikmet Hamur, Mutlu Buyuklu, Gokhan Ceyhun, Ergun Kutlusoy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):51-56 | DOI: 10.5507/bp.2021.001
Increased coronary artery disease (CAD) severity is linked to unfavorable cardiovascular complications. Early detection of patients at high risk for cardiovascular complications is extremely important in terms of adjusting preventive treatment regimens. For this purpose, the aortic propagation velocity (APV) measurement is a practical, noninvasive, and inexpensive approach for detecting CAD severity. In this study, the authors found that APV was independently associated with CAD severity in a large cohort of patients undergoing coronary angiography for stable angina pectoris.
Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms
Jan Bardon, Sandra Kurcova, Monika Chudackova, Pavel Otruba, David Krahulik, Martin Nevrly, Petr Kanovsky, Jana Zapletalova, Jan Valosek, Petr Hlustik, Miroslav Vastik, Marketa Vecerkova, Lenka Hvizdosova, Katerina Mensikova, Egon Kurca, Stefan Sivak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):57-62 | DOI: 10.5507/bp.2020.034
This study evaluated the impact of location of deep brain stimulation electrode active contact within different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson’s disease. The authors demonstrated a relationship between improvement of non-motor symptoms and the hemisphere, left/right of the electrode, rather than its precise location within the specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease.
Haplotype analysis of the X chromosome in patients with Turner syndrome in order to verify the possible effect of imprinting on selected symptoms
Petr Vrtel, Radek Vrtel, Eva Klaskova, Dita Vrbicka, Katerina Adamova, Jan Pavlicek, Vaclav Hana, Vaclav Hana Jr., Ondrej Soucek, Veronika Stara, Jan Lebl, Marta Snajdrova, Jirina Zapletalova, Tomas Furst, Sabina Kapralova, Zdenek Tauber, Eva Krejcirikova, Marketa Routilova, Julia Stellmachova, Radek Vodicka, Martin Prochazka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):63-67 | DOI: 10.5507/bp.2020.060
The aim of the study was to demonstrate or disprove the influence of the origin of the X chromosome on individual clinical manifestations in Turner syndrome patients. The results show that the evaluated clinical manifestations of Turner syndrome were not affected by the origin of the (maternal/paternal) X chromosome, i.e. they are not subject to imprinting.
Combined and intravenous administration of TXA reduces blood loss more than topical administration in primary total knee arthroplasty: A randomized clinical trial
Jiri Lostak, Jiri Gallo, Lubos Balaz, Jana Zapletalova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):68-76 | DOI: 10.5507/bp.2020.045
Two intravenous doses or combined regimen are preferable routes of administration of tranexamic acid in patients undergoing primary knee arthroplasty. Simple topical administration was not as effective as other tested regimens but could be indicated in cases of contraindications to systemic administration.
Is ultra low-dose CT with tin filtration useful for examination of SI joints? Can it replace X-ray in diagnostics of sacroiliitis?
Eva Korcakova, Jana Stepankova, David Suchy, Petr Hosek, Kristyna Bajcurova, Jan Pernicky, Hynek Mirka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):77-83 | DOI: 10.5507/bp.2021.008
Tin filtration reduces the effective doses of low-dose CT on sacroiliac joints to values lower than X-ray. Tin-filtrated ultra-low-dose CT offers better overall diagnostic performance than conventional radiography. Tin-filtrated ultra-low-dose CT is a suitable method of first choice for the evaluation of sacroiliac joints in patients suffering from axial spondyloarthritis.
Proton magnetic resonance spectroscopy changes in the brainstem in patients after mild traumatic brain injury with loss of consciousness
Robert Ruzinak, Michal Bittsansky, Martina Martinikova, Vladimir Nosal, Ema Kantorova, Jana Ballova, Monika Turcanova Koprusakova, Petra Hnilicova, Marian Grendar, Robert Dusenka, Branislav Kolarovszki, Kamil Zelenak, Egon Kurca, Stefan Sivak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):84-90 | DOI: 10.5507/bp.2021.029
In this pilot study, the authors found subtle metabolic changes in the upper brainstem detected by proton magnetic resonance spectroscopy (1H-MRS) in patients within 3 days after mild traumatic brain injury (MTBI) with post-traumatic loss of consciousness (LOC). Similar 1H-MRS studies on the relationship between LOC and the brainstem in MTBI are absent in the medical literature to date. The findings indicate that 1H-MRS maybe a potential biomarker for MTBI associated with LOC.
Body composition changes during and after curative chemotherapy in patients with testicular cancer
Otakar Semerad, Tomas Buchler, Jiri Vejmelka, Aneta Rozsypalova, Jitka Tomesova, Pavel Kohout
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):91-96 | DOI: 10.5507/bp.2020.058
Accelerated atherosclerosis is one of the leading causes of premature death in patients after chemotherapeutic treatment of testicular germ-cell tumors. Thie study showed that the evaluation of body composition by bioelectrical impedance analysis (BIA) in these patients can reveal individuals at increased risk of future atherosclerotic complications and therefore potentially help to reduce the negative effects of chemotherapy.
Patients with metastatic renal cell carcinoma treated with cabozantinib in the Czech Republic: analysis of four cancer centers
Igor Richter, Alexandr Poprach, Anezka Zemankova, Tomas Buchler, Jiri Bartos, Vladimir Samal, Hana Studentova, Aneta Rozsypalova, Josef Dvorak, Ondrej Brom, Bohuslav Melichar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):97-104 | DOI: 10.5507/bp.2020.055
These data analyses are the first for cabozantinib-treated patients in the Czech Republic. The evaluation of treatment outcomes and tolerance in an initial group of treated patients with metastatic renal cell carcinoma provides important evidence for informing future treatment decisions.
Case reports
Cystic ovarian teratoma as a novel tumor and growth hormone deficiency as a new condition presenting in Multiple Endocrine Neoplasia type 2B: Case reports and review of the literature
Renata Pomahacova, Petra Paterova, Eva Nykodymova, Eliska Vaclavikova, Pavla Sykorova, Katerina Personova, Ramir Katra, Ivan Subrt, Josef Sykora
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):105-111 | DOI: 10.5507/bp.2021.051
This article decribes growth retardation, growth hormone deficiency and cystic ovarian teratoma as new possible symptoms in Multiple Endocrine Neoplasia type 2B.
Gorlin-Goltz syndrome with familial manifestation
Jindųich Pazdera, Alena Santava, Zdenek Kolar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):112-116 | DOI: 10.5507/bp.2020.063
Odontogenic keratocysts, skeletal abnormalities and multiple basal cell carcinomas are the main kriteria for clinical manifestation of nevoid basal cell carcinoma (NBCCS, Gorlin Goltz syndrome). Mutations of PTCH1 gene are thought to be the cause of this disease. These abnormalities can be transmitted from one generation to another and lead to a familial occurence of the disease. The authors found a familial manifestation of NBCCS in two pairs of patients. With regard to the possibility of familial occurence of NBCCS, it is necessary to pay increased attention to family history and, if necessary, to ensure clinical and genetic examination of parents and other family members.
Cervical lymphocele: A rare complication following salvage surgery for ocular adnexal apocrine adenocarcinoma. A case report and review of the literature
Lukas Hauer, Jiri Gencur, Petr Posta, Zdenek Kasl, Stepan Rusnak, Alena Skalova, Miroslava Chalupova, Jan Liska, Vlasta Merglova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(1):117-125 | DOI: 10.5507/bp.2020.051
The authors present a case of extremely rare, recurrent metastatic apocrine adenocarcinoma of the ocular orbit which was primarily managed with multiple eye-sparing excisions and adjuvant proton therapy. Due to a locoregional recurrence, salvage surgery including partial orbitectomy with orbital exenteration and neck dissection was performed, previously not reported in the literature. A cervical lymphocele as a rare complication of this procedure was successfully treated with extirpation and thoracic duct perforation repair. The management of ocular adnexal apocrine adenocarcinoma is based only on the sporadic cases encountered in literature. Current recommendations for the treatment of cervical lymphoceles following neck dissections were adapted from experiences with the therapy of these lesions in other localizations. To increase the knowledge of these pathological conditions among ophthalmologists, maxillofacial and head and neck surgeons, a literature review of all published cases was conducted.