Biomedical papers, 2019 (vol. 163), issue 3
Reviews
Indirect insulin resistance detection: Current clinical trends and laboratory limitations
Sylwia Placzkowska, Lilla Pawlik-Sobecka, Izabela Kokot, Agnieszka Piwowar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):187-199 
The HOMA1-IR index is the most frequently proposed indirect index of insulin resistance assessment in clinical and laboratory practice, and its use is also widespread in epidemiological studies. There is a justified need to set reference intervals for indirect insulin resistance indicators for particular populations, ethnic groups, etc. in order to reliably diagnose insulin resistance and increase metabolic disease prevention. When defining reference intervals, various limitations should be taken into account, primarily analytical and pre-analytical ones and differences between populations.
The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR
Michal Konrad Zarobkiewicz, Wioleta Kowalska, Miroslaw Slawinski, Jacek Rolinski, Agnieszka Bojarska-Junak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):200-206
This review summarises recent knowledge on IL-22 in the pathogenesis of multiple sclerosis and proposes a functional link between IL-22 and two transcription factors - c-Maf and AHR.
Changes in the anterior segment of the eye following uncomplicated pars plana vitrectomy. A review
Adam Kopecky, Jan Nemcansky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):207-211
This review covers possible changes in the anterior segment of the eye after uncomplicated pars plana vitrectomy. The goal was to provide clinically-related conclusions from the studies as there are almost no comprehensive clinical reviews on this subject.
Original papers
Characteristic CT features of pheochromocytomas - probability model calculation tool based on a multicentric study
Filip Ctvrtlik, Zbynek Tudos, Paulina Szasz, Zuzana Sedlackova, Igor Hartmann, Jan Schovanek, Zdenek Frysak, Iva Macova, Tomas Zelinka, Milan Hora, Eva Kocova, Jaroslav Pacovsky, Michal Krsek, Viera Lehotska, Emilia Mojtova, Josef Molnar, Vladimir Vanek, Karel Pacak, Jan Baxa
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):212-219
This was a multicenter international study, to identify typical CT characteristics of an uncommon adrenal tumour-pheochromocytoma. The authors created and tested a mathematical model to determine the shape of lesions that could be used in anatomical imaging techniques. They found that pheochromocytomas typically present as spherical in shape, with a sharp, central necrosis and "ring sign" compared to other adrenal tumors. The authors created a simple imaging tool, which will be freely available on the Internet, to calculate the probability of a pheochromocytoma on the basis of selected imaging features
CT-guided biopsy of the mediastinal masses. Can anatomical relationships predict complications?
Petr Dvorak, Petr Hoffmann, Eva Kocova, Petr Habal, Marketa Nova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):220-226
The percutaneous approach can reach all mediastinal parts using only local anesthesia and CT guidance. The biopsies of the affected middle mediastinum areas are associated with statistically higher non-serious complication rates while preserving a high diagnostic accuracy.
Comparison of different methods of ABI acquisition for detection of peripheral artery disease in diabetic patients
Miroslav Homza, Ondrej Machaczka, Martin Porzer, Milan Kozak, Jiri Plasek, David Sipula
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):227-232
In diabetic patients, the authors studied screening test parameters of the ankle brachial index (ABI) for detection of peripheral arterial disease (PAD) calculated using systolic blood pressure of the individual arteries at the ankle level, lower and higher than the pressures. The calculation using lower ankle pressure provided the best test parameters, especially where negative predictive value and sensitivity is concerned. However, specificity and positive predictive values were not very high, which indicates that this method is suitable rather for identification of patients who do not need any further examination than for a reliable identification of patients with PAD. Diabetic patients with any ABI abnormality (1.4 or measurement failure) should be referred for further examination.
Midterm outcomes of mini-invasive surgical and hybrid ablation of atrial fibrillation
Marek Pojar, Ludek Haman, Petr Parizek, Andrej Myjavec, Jan Gofus, Jan Vojacek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):233-240
The authors report on the efficacy of a staged hybrid technique for atrial fibrillation which combines the mini-invasive thoracoscopic approach and endocardial treatment (two-stage hybrid procedure). The midterm outcomes for paroxysmal and persistent atrial fibrillation are good with a very low incidence of post-operative complications.
A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients
Thomas Saller, Axel Petzold, Henrik Zetterberg, Jens Kuhle, Daniel Chappell, Vera von Dossow, Felix Klawitter, Tobias Schürholz, Christian Hagl, Daniel A Reuter, Bernhard Zwissler, Johannes Ehler
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):241-246
In a case series of nine patients for cardiac surgery, the authors examined biomarkers of neuroaxonal injury to predict and detect delirium. Cardiopulmonary bypass procedures induce an increase in neuroaxonal injury biomarkers in contrast to off-pump surgery procedures. Pre-operative tau protein levels may predict postoperative delirium. Post-operative longitudinal NfL levels might help to detect the emergence of delirium.
High prevalence of abdominal aortic aneurysm in patients with inguinal hernia
Angelos Megalopoulos, Orestis Ioannidis, Ioannis Varnalidis, Maria Ntoumpara, Lina Tsigriki, Konstantinos Alexandris, Christiana Anastasiadou, Parpoudi Styliani, George Paraskevas, Ioannis Mantzoros
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):247-252
There is increased prevalence of inguinal hernia in patients with abdominal aortic aneurysm. However limited data exists regarding the presence of abdominal aortic aneurysm in patients with inguinal hernia. This study showed that there is an increased prevalence of abdominal aortic aneurysm in patients with inguinal hernia, especially in smokers, with hypertension and with bilateral or direct hernia. Periodic ultrasonound examination may play an important role in screening and early diagnosis of abdominal aortic aneurysm in these patients.
Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared
Vladimir Hrabovsky, Vladimir Blaha, Radomir Hyspler, Alena Ticha, Martina Skrobankova, Zdenek Svagera
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):253-258
This study deals with examination of the plasma cholesterol profile (total cholesterol, LDL and HDL cholesterol) and both processes of cholesterol acquisition during acute upper gastrointestinal haemorrhage with emphasis on liver cirrhosis.
MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia
Barbara Vonkova, Ivona Blahakova, Lukas Hruban, Petr Janku, Sarka Pospisilova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):259-264
This work intended to determine the rate of fetal miR-210 expression in maternal blood from mothers with and without acute fetal hypoxia at the time of delivery. The authors also studied the dynamics of change in this expression after delivery in mothers with acute fetal hypoxia. The results confirmed the increased expression of fetal miR-210 in mother's blood in the case of fetal hypoxia, and after independent confirmation studies, this can be considered as a marker for noninvasive examination of fetal hypoxia status.
The prevalence of maternal hypothyroidism in first trimester screening from 11 to 14 weeks of gestation
Tomas Salek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):265-268
Maternal thyroid dysfunction is associated with increased risk of various adverse maternal and child outcomes. The prevalence of maternal hypothyroidism is not well established. The prevalence of hypothyroidism for twin pregnancies was no higher than that for singleton pregnancies; 6.42 % (7/ 109) vs. 5.32 % (264/ 4965), respectively; P = 0.61.
Descemet membrane endothelial keratoplasty with stromal rim (DMEK-S) in complicated patients
Pavel Studeny, Miroslav Veith, Deli Krizova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):269-273
A retrospective case control study to evaluate outcomes of the hybrid technique of posterior lamellar keratoplasty (DMEK-S) in eyes with multiple ocular pathologies. The authors compared a consecutive group of complicated patients with a control group of eyes with no other ocular pathology. DMEK-S in complicated eyes in these 4 patients led to a marked improvement of visual acuity. When compared to surgeries in uncomplicated eyes DMEK-S results in a higher rate of postoperative complications.
Assessment of the impact of temporomandibular disorders on maximum bite force
Jelena Todic, Brankica Martinovic, Jasna Pavlovic, Sasa Tabakovic, Milo¹ Staletovic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):274-278
Maximum bite force, as an indicator of the functional potential of the stomatognathic system, is significantly decreased in persons with temporomandibular disorders. This was confirmed by the registration of values of maximum bite force by means of the new ultra-thin Prescale Pressure measurement films.
Single agent daratumumab in advanced multiple myeloma possesses significant efficacy even in an unselected "real-world" population
Jiri Minarik, Ludek Pour, Vladimir Maisnar, Ivan Spicka, Alexandra Jungova, Tomas Jelinek, Lucie Brozova, Petra Krhovska, Vlastimil Scudla, Roman Hajek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):279-283
Single agent daratumumab has significant activity in highly pretreated MM patients. The effect is maintained even in an unselected real world population and in patients refractory to previous treatment including proteasome inhibitors and immunomodulatory drugs.