Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(3):200-206

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

Michal Konrad Zarobkiewicza, Wioleta Kowalskaa, Miroslaw Slawinskib, Jacek Rolinskia, Agnieszka Bojarska-Junaka
a Chair and Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland
b Chair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Lublin, Poland

The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors - AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.

Keywords: multiple sclerosis, IL-22, transcription factors, c-Maf, AHR, EAE

Received: February 18, 2019; Revised: May 23, 2019; Accepted: May 24, 2019; Prepublished online: June 4, 2019; Published: September 23, 2019  Show citation

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Zarobkiewicz, M.K., Kowalska, W., Slawinski, M., Rolinski, J., & Bojarska-Junak, A. (2019). The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR. Biomedical papers, 163(3), 200-206
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