Biomedical papers, 2019 (vol. 163), issue 2
Reviews
The effect of quercetin on microRNA expression: A critical review
Zdenek Dostal, Martin Modriansky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):95-106 | DOI: 10.5507/bp.2019.030 
Quercetin is a widely distributed compound isolated from plants and is one of the most abundant dietary flavonoids. It is able to modulate expression of miRNA, many of which are recognized as oncogenic or tumor suppressor miRNAs. This review is a critical evaluation of recent research on miRNAs modulated by quercetin.
Subclinical atrial fibrillation - what is the risk of stroke?
Jiri Plasek, Milos Taborsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):107-113 | DOI: 10.5507/bp.2018.083
Subclinical atrial fibrillation (SCAF) opens a new field in clinical cardiology. SCAF diagnosis was first possible due to prolonged ECG monitoring, and device-detected episodes of atrial fibrillation. The recent literature has placed considerable attention on the link between subclinical atrial fibrillation and the risk of stroke. This article reviews all pivotal trials, comments on recent consensus statements and controversies regarding atrial high rate episodes and their appropriate interpretation.
Invertebrate and vertebrate models in aging research
Manoj Kumar Chaudhary, Syed Ibrahim Rizvi
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):114-121 | DOI: 10.5507/bp.2019.003
Recent scientific discoveries have to a large extent elucidated the hallmarks of aging. The stage is now set for research on anti-aging interventions. Model organisms provide essential platforms for aging research. This review provides in- depth knowledge on the model organisms which can mimic aging in higher animals and humans
Nanodrugs used in cancer therapy
Katerina Kopeckova, Tomas Eckschlager, Jakub Sirc, Radka Hobzova, Johana Plch, Jan Hrabeta, Jiri Michalek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):122-131 | DOI: 10.5507/bp.2019.010
Nanotechnology is a very rapidly evolving science that is dramatically impacting multifarious fields of human life including medicine and the development of new anti-cancer therapies. Anti-cancer nanodrugs in the clinic and related research are discussed.
Original papers
Serum C-peptide level correlates with the course of muscle tissue healing in the rabbit model of critical limb ischemia
Zdenek Tauber, Katerina Cizkova, Maria Janikova, Jana Jurcikova, Katerina Vitkova, Lubomir Pavliska, Ludmila Porubova, Agata Krauze, Carlos Fernandez, Frantisek Jaluvka, Iveta Spackova, Ivo Lochman, Martin Prochazka, Brian H. Johnstone, Vaclav Prochazka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):132-140 | DOI: 10.5507/bp.2018.048
The authors demonstrated a statistically significant positive correlation between the early healing phases in tissue samples and C-peptide levels in peripheral blood of rabbits. C-peptide could thus be used to monitor the course of the tissue healing process.
Identification of novel OXA-134-like β-lactamases in Acinetobacter lwoffii and Acinetobacter schindleri isolated from chicken litter
Patrik Mlynarcik, Jan Bardon, Miroslava Htoutou Sedlakova, Petra Prochazkova, Milan Kolar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):141-146 | DOI: 10.5507/bp.2018.037
The article describes novel OXA-134-like-producing Acinetobacter spp. isolated from chicken farm litter, and underscores the role of chicken environment as a reservoir for resistance determinants.
The influence of mode of anaesthesia for caesarean delivery on neonatal Apgar scores in the Czech Republic and Slovakia: secondary analysis of the results of an international survey in 2015
Hana Harazim, Petr Stourac, Jan Blaha, Monika Grochova, Radka Klozova, Pavlina Noskova, Dagmar Seidlova, Stanislava Richterova, Michal Svoboda, Jiri Jarkovsky, Xenia Silova, Bozena Jezova, Jiri Steinbach, Martin Zemanek, Jitka Mannova, Jan Slavik, Zuzana Novakova, Lubica Misakova, Jozef Firment
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):147-154 | DOI: 10.5507/bp.2019.008
The authors carried out a survey in two European countries to investigate the labor anaesthesia practices and its secondary analysis to assess the impact of anaesthesia on neonatal outcomes.
Gestational surrogacy in the Czech Republic
David Rumpik, Tatana Rumpikova, Michal Pohanka, Pavel Ventruba, Silvie Belaskova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):155-160 | DOI: 10.5507/bp.2018.040
Gestational surrogacy offers an alternative way for a small group of women to have their own genetic children. In the 14 years of experience the authors have shown that treatment of young women with specific indications for treatment with GS is beneficial and relatively free of complications. The surrogacy program has been successfully implemented and has become an integral part of the treatment of some cases of infertility.
Ciprofloxacin prophylaxis during autologous stem cell transplantation for multiple myeloma in patients with a high rate of fluoroquinolone-resistant gram-negative bacteria colonization
Alzbeta Zavrelova, Pavla Paterova, Filip Gabalec, Pavel Zak, Jakub Radocha
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):161-165 | DOI: 10.5507/bp.2018.047
Fluoroquinolones are widely recommended and used for prophylaxis of bacterial infection during periods of high risk neutropenia. Their efficacy for hematooncology patients with neutropenia has been repeatedly proven during recent years, especially in the case of autologous stem cell transplantation. The goal was to evaluate the impact of cessation of ciprofloxacin prophylaxis during stem cell transplantation for multiple myeloma. The authors resumed ciprofloxacin prophylaxis as there was a significant reduction of febrile episodes and consequently a sparing effect of antibiotics used for treatment of this condition.
Association of serum adipocyte fatty acid-binding protein and apolipoprotein B /apolipoprotein A1 ratio with intima media thickness of common carotid artery in dyslipidemic patients
Jiri Orsag, David Karasek, Milan Halenka, Helena Vaverkova, Jaromira Spurna, Veronika Kubickova, Jiri Lukes, Josef Zadrazil
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):166-171 | DOI: 10.5507/bp.2018.043
This study evaluated relationships between serum Adipocyte fatty acid-binding protein (A-FABP) levels in dyslipidemic patients and assessed the possibility of modeling intima media thickness of common carotid artery by A-FABP levels and other observed characteristics. The data revealed higher A-FABP levels and C- IMT in dyslipidemic individuals with metabolic syndrome. In contrast to these findings A-FABP did not confirm its importance as a predictor of C-IMT in dyslipidemic patients. An interesting secondary finding is revealing of ApoB/ApoA1 ratio as an independent predictor of common C-IMT in dyslipidemic patients without metabolic syndrome.
Influence of preoperative information support on anxiety, pain and satisfaction with postoperative analgesia in children and adolescents after thoracic surgery: A randomized double blind study
Lucyna Tomaszek, Grazyna Cepuch, Dariusz Fenikowski
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):172-178 | DOI: 10.5507/bp.2018.060
Information support from a psychologist offered prior to a thoracic surgery reduced the level of postoperative state anxiety solely in children with lower levels of trait anxiety. Less satisfaction with postoperative analgesia correlated with high level of postoperative state anxiety.
Changes in subfoveal choroidal thickness after uncomplicated cataract surgery
Gaile Gudauskiene, Indre Matuleviciute, Ruta Mockute, Evelina Maciulaityte, Dalia Zaliuniene
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):179-183 | DOI: 10.5507/bp.2018.076
The research aim was to analyze the effects of uneventful phacoemulsification surgery on subfoveal choroidal thickness (SFCT) using swept-source optical coherence tomography (SS-OCT). The authors examined a total of 30 eyes of 23 patients with senile cataract who received uncomplicated cataract surgery by phacoemulsification and intraocular lens implantation. The findings revealed that except for the inferior sectors, subfoveal choroidal thickness changes were insignificant 1 month after the cataract surgery. However, there was a significant increase in subfoveal choroidal thickness 3 months after surgery in all sectors except the inner superior sector.
Case report
Apparent foreign-body-like structure detected in the left atrium after catheter ablation for persistent atrial fibrillation
Tomas Skala, Ondrej Moravec, Martin Hutyra, Zbynek Tudos, Martin Kocher, Milos Taborsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):184-186 | DOI: 10.5507/bp.2018.052
A patient after previous catheter ablation for persistent atrial fibrillation was indicated for reablation. Transesophageal echocardiography showed a straw-like foreign body with a character of transseptal sheath; this was confirmed on MRI and CT. The patient insisted on extraction. A fibrous chord-like material (40 x 2.5 mm) was found in the LA stretched out between right superior pulmonary vein antrum and LA wall beneath right inferior pulmonary vein corresponding with all imaging methods. Microscopy showed myocardial tissue with continuous transition to fibrinous elastic vessel and a fibrinous tissue with focal dystrophic calcification. No signs of foreign material were found. The patient survived with no complications and has a stable sinus rhythm since surgery.