Biomedical papers, 2022 (vol. 166), issue 4

Reviews

Skin manifestations of pancreatic diseases

Lumir Kunovsky, Petr Dite, Eva Brezinova, Libuse Sedlakova, Jan Trna, Petr Jabandziev

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):353-358 | DOI: 10.5507/bp.2022.035  

This review article summarizes current knowledge on the skin manifestations of pancreatic disorders which are of both diagnostic and prognostic value.

Specific microRNAs and heart failure: time for the next step toward application?

Radka Sigutova, Lukas Evin, David Stejskal, Vera Ploticova, Zdenek Svagera

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):359-368 | DOI: 10.5507/bp.2022.028  

This is a critical evaluation of selected microRNAs as important indicators of the anatomical-pathological changes in heart disease leading to heart failure. MicroRNAs are also interesting as potential drugs in the treatment of these diseases but to use them in cardiovascular examinations or as drugs, requires answers to practical questions such as ease of laboratory determination and their limitations. This review provides valuable material for responding to these questions.

Arterial stiffness in aortic stenosis - complex clinical and prognostic implications

Adriana Albu, Ioana Para, Cristina Bidian

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):369-379 | DOI: 10.5507/bp.2022.040  

Arterial stiffness and aortic stenosis share similar cardiovascular risk factors and they are frequently associated, leading to increased left ventricular afterload. Even though accurate estimation of arterial stiffness in AoS is challenging, the coexistence of an increased pulsatile load may influence patient outcome before as well as after aortic valve replacement.

Original papers

Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and RAGE promising candidates?

Pavel Horak, Petr Suhaj, Radoslav Matej, Monika Cervinkova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):380-385 | DOI: 10.5507/bp.2022.014  

This paper focuses on potential novel diagnostic markers MMP 19 and RAGE in inflammatory bowel diseases and colorectal cancer.

The short- and long-term outcomes of pancreaticoduodenectomy for distal cholangiocarcinoma

Pavel Skalicky, Ondrej Urban, Jiri Ehrmann, Hana Svebisova, Dusan Klos, Jana Tesarikova, Cestmir Neoral, Katerina Knapkova, Martin Lovecek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):386-392 | DOI: 10.5507/bp.2021.043  

The short- and long-term outcomes of radical surgical therapy of distal cholangiocarcinoma are evaluated in this paper. The authors demonstrate that vascular resection is the most serious negative prognostic factor for long-term survival in surgically treated patients with distal cholangiocarcinoma. Surgical mortality occurs in a significant group of patients who die in the first year following pancreaticoduodenectomy.

Prognostic value of blood cell count-derived ratios in BRAF-mutated metastatic melanoma

Jindrich Kopecky, Ondrej Kubecek, Peter Priester, Hana Vosmikova, Eva Cermakova, Aneta Kyllarova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):393-404 | DOI: 10.5507/bp.2021.053  

The blood cell count-derived ratios are easy to gain and might help in therapy decision processes, especially if there are more available options.

Tumour volume and radiotherapy prolongation in locally advanced head and neck cancer patients treated with radical IMRT

Radka Lohynska, Michaela Jirkovska, Bela Malinova, Alena Novakova-Jiresova, Zdenka Pechacova, Zuzana Kratka

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):405-411 | DOI: 10.5507/bp.2021.047  

Factors influencing overall survival, disease-free survival, and local control in patients with locally advanced head and neck cancer after radical radioherapy were retrospectively evaluated in this paper. The most important prognostic factors were total tumor volume (GTV) and radiotherapy treatment time (RTT). The best results were achieved in patients with GTV ≤ 55 cc and RTT ≤ 48 days (mean LC 8.1, DFS 7.1 and OS 6.4 years) and the worst results with GTV > 55 cc and RTT > 48 days (mean LC 4.4, mean DFS 3.2 and median OS 2.6 years).

Myringosclerosis as a predictor of the requirement for a permanent pacemaker in patients with drug-related atrioventricular block

Muharrem Said Cosgun, Hikmet Hamur, Husnu Degirmenci, Resit Coskun, Mustafa Rauf Karayumak, Ugur Karabiyik, Ismail Salcan

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):412-417 | DOI: 10.5507/bp.2022.030  

Drug-related atrioventricular bloc (DR-AVB) may develop, even if anti-arrhythmic drugs are used in appropriate doses. About half of these patients require a permanent pacemaker. Myringosclerosis is a marker that can predict high-grade DR-AVB that is irreversible despite drug discontinuation.

Modern diagnostic and therapeutic approaches in familial maculopathy with reference to North Carolina macular dystrophy

Jana Nekolova, Alexandr Stepanov, Bohdan Kousal, Marketa Stredova, Nada Jiraskova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):418-427 | DOI: 10.5507/bp.2021.037  

We demonstrate a family with macular dystrophy, resembling North Carolina Macular dystrophy, in which genetic analysis excluded mutations previously reported to be pathogenic for NCMD. We present modern diagnostic and therapeutic approaches and a favorable effect of anti-VEGF therapy in this very rare familial maculopathy.

Should 3D volume assessment of the corpus callosum and cerebellar vermis be a part of a routine second trimester screening?

Michaela Maderkova Tozzi, Jana Furstova, Marek Lubusky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):428-433 | DOI: 10.5507/bp.2021.033  

The article describes the 3D technique of ultrasound scanning as an auxiliary diagnostic tool in the examination of the corpus callosum and vermis cerebella during evaluation of the detailed morphology of the fetus in II. trimester of pregnancy. It presents the success and quality of scanning results in two examined planes, in relation as well to maternal factors.

Effect of targeting and generator type on efficacy of extracorporeal shock wave lithotripsy

Michaela Motolova, Milan Kral

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):434-440 | DOI: 10.5507/bp.2022.029  

Radiation techniques play a significant role in the management of urolithiasis. The effort to eliminate radiation exposure for patients (especially children) led us to research wheather ultrasound guided extracorporeal shock wave lithotripsy (ESWL) is not inferior comparing to usually preferred fluoroscopic guidance. Our results support this theory of equivalency of these two methods. We also focused on effectivity of ESWL on stone free rate and we did not prove differences between different types of shock wave generators.

Adherence of obstructive sleep apnoea syndrome patients to positive airway pressure therapy - 10-year follow-up

Samuel Genzor, Jan Prasko, Jakub Vanek, Amjad Ghazal Asswad, Shayan Nadjarpour, Milan Sova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):441-446 | DOI: 10.5507/bp.2021.041  

Continuous positive airway pressure (CPAP) is the most effective therapy for obstructive sleep apnoea syndrome (OSAS). The aim of this study was to assess the ten-year adherence to CPAP therapy, and to define the factors influencing it. Sufficient adherence, which was defined as more than 4 hours of CPAP use per night, was found in 57% of patients in the first year with no subsequent significant change over the next 9 years. Adherence to therapy correlated significantly with the severity of OSAS and Epworth Sleepiness Scale score but did not correlate with the pressure used or the age of the patient.

Case reports

Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report.

Jan Liska, Veronika Liskova, Ondrej Trcka, Ondrej Ondic, Lukas Hauer, Jan Baxa, Denisa Kacerovska

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):447-450 | DOI: 10.5507/bp.2021.039  

The authors present a case of paraneoplastic pemphigus expanding the spectrum of known associated internal malignancies describing concomitant tonsillar HPV associated squamous cell carcinoma. The oral presentation of paraneoplastic pemphigus was the first manifestation of this malignancy allowing its early detection by the whole-body 18F-FDG PET/MRI and subsequent successful treatment.

An EGFR-mutant lung adenocarcinoma that transformed into small-cell lung cancer. A case report

Gabriela Chowaniecova, Peter Berzinec, Gabriela Kosturiakova, Lukas Plank, Anna Farkasova, Monika Sekeresova, Dominik Juskanic, Dalibor Ondrus

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):451-454 | DOI: 10.5507/bp.2022.037  

This case report describes a patient with lung adenocarcinoma harbouring a mutation of epidermal growth factor receptor (EGFR), treated with several lines of therapy including targeted tyrosine kinase inhibitors. A rare transformation of lung adenocarcinoma into small-cell lung cancer was confirmed by biopsies and by the finding of EGFR mutation in the sample of SCLC, which otherwise is never found in SCLC. This is the first case of a well proven transformation of lung adenocarcinoma into SCLC in our department, and also in Slovak Republic and the Czech Republic to be published.