Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(4):405-411 | DOI: 10.5507/bp.2021.047

Tumour volume and radiotherapy prolongation in locally advanced head and neck cancer patients treated with radical IMRT

Radka Lohynskaa#, Michaela Jirkovskab#, Bela Malinovab, Alena Novakova-Jiresovaa, Zdenka Pechacovac, Zuzana Kratkad
a Department of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic
b Department of Oncology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
c Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czech Republic
d Department of Otorhinolaryngology, Thomayer University Hospital Prague, Czech Republic

Aims: The relationship of tumour volume, radiotherapy treatment time and other prognostic factors affecting prognosis was evaluated.

Methods: 184 patients with locally advanced head and neck cancer were treated with radical intensity modulated radiotherapy (IMRT) and compared retrospectively.

Results: In the multivariate analysis the overall survival was dependent on gross tumour volume (GTV), clinical stage (CS), radiotherapy treatment time (RTT) and p16 status. Local control was influenced by GTV, overall RTT and age. DFS was significantly affected by GTV, CS, RTT, p16 status and concomitant chemotherapy (CHT).

Conclusions: The tumour volume and the radiotherapy treatment time were the most significant prognostic factors with the best outcomes in patients with GTV ≤ 55 cc and RTT ≤ 48 days (mean LC 8.1, DFS 7.1 and OS 6.4 years) and worst outcomes with GTV > 55 cc and RTT >48 days (mean LC 4.4, mean DFS 3.2 and mean OS 2.6 years).

Keywords: tumour volume, radiotherapy treatment time, local control, survival, head and neck cancer, IMRT

Received: May 29, 2021; Revised: July 12, 2021; Accepted: July 13, 2021; Prepublished online: August 24, 2021; Published: December 7, 2022  Show citation

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Lohynska, R., Jirkovska, M., Malinova, B., Novakova-Jiresova, A., Pechacova, Z., & Kratka, Z. (2022). Tumour volume and radiotherapy prolongation in locally advanced head and neck cancer patients treated with radical IMRT. Biomedical papers, 166(4), 405-411. doi: 10.5507/bp.2021.047
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