Biomedical papers, 2018 (vol. 162), issue 1


Jitka Ulrichova, Vilim Simanek, Jan Vaclavik, Jan Bouchal

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):


Irritable bowel syndrome - from etiopathogenesis to therapy

Biljana Radovanovic-Dinic, Snezana Tesic-Rajkovic, Sasa Grgov, Gordana Petrovic, Valentina Zivkovic

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):1-9 | 10.5507/bp.2017.057

The significance of the paper is in the fact that it includes the most relevant and the latest information on this very common functional syndrome. The aim of the authors is to provide both comprehensive and concise data which will be of value to doctors whose clinical practice brings them into contact with patients with the clinical picture of this syndrome.

Vulnerable atherosclerotic plaque - a review of current concepts and advanced imaging

Miloslav Spacek, David Zemanek, Martin Hutyra, Martin Sluka, Milos Taborsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):10-17 | 10.5507/bp.2018.004

Vulnerable atherosclerotic plaque is currently a highly debated topic in cardiology, particularly in the field of coronary and carotid interventions. The aim of this article is to provide a comprehensive overview of the most up-to-date information on this topic with a focus on advanced imaging.

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice

Leos Landa, Jan Jurica, Jiri Sliva, Monika Pechackova, Regina Demlova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):18-25 | 10.5507/bp.2018.007

The legalisation of medical cannabis is associated with increasing interest in its practical applications. The review covers available cannabis based products in general, both in the Czech Republic and the rest of Europe. It provides a summary of clinical experience with cannabis in the treatment of pain and multiple sclerosis. Third, it describes the pharmacokinetics of medical cannabis constituents and routes of administration. Finally, it provides information on preparing medical cannabis in a faculty pharmacy.

Original papers

The attitudes of IVF patients treated in the Czech Republic towards informing children born after gamete donation

Tatana Rumpikova, Ivana Oborna, Silvie Belaskova, Hana Konecna, David Rumpik

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):26-31 | 10.5507/bp.2017.050

A closer view of the current situation in the gamete donation programme in the Czech Republic where anonymous donation is available. The survey on foreign and Czech future parents concluded that they prefer to retain anonymity and do not see any advantage for a child to know the identity of the donor. The authors maintain that psychosocial factors are the most important oneshealthy child development.

The presence of gasping predicts long-term survival in out-of-hospital cardiac arrest patients

Jiri Knor, Jana Seblova, Roman Skulec, Dominika Seblova, Jiri Malek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):32-35 | 10.5507/bp.2017.053

The presence of gasping at the time of EMS arrival on the scene is associated with improved chance of return of spontaneous circulation and six-month survival. The latter is a new finding. EMS dispatchers and the EMS ambulance teams should recognize and understand this phenomenon as it can have impact on medical care provided to OHCA patients.

Autonomic control of blood circulation in patients undergoing elective carotid endarterectomy

Karel Vykoupil, Jan Galuszka, Petr Drac, Milos Taborsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):36-39 | 10.5507/bp.2017.045

The autonomic nevous system can be impaired in the presence of atheroma in the carotid sinus region. The authors assessed the effect of elective unilateral carotid endarterectomy on cardiovascular autonomic functions as a major prognostic factor of cardiovascular health.

Electrical stimulation of hyoid muscles in post-stroke dysphagia

Petr Konecny, Milan Elfmark

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):40-42 | 10.5507/bp.2017.043

Electrical stimulation (ES) of the hyoid muscles for dysphagia is a new therapy which significantly improves swallowing in cases of post-stroke patients with dysphagia. Videofluoroscopy (VFSS) is being used for measuring improvement in swallowing. It is reliable and provides objective evidence that ES of suprahyoid muscles is effective according to the principles of evidence-based medicine.

Ultrasound detection of diaphragm position in the region for lung monitoring by electrical impedance tomography during laparoscopy

Kristyna Buzkova, Martin Muller, Ales Rara, Karel Roubik, Tomas Tyll

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):43-46 | 10.5507/bp.2018.005

The authors found that the diaphragm is present in the region of conventional lung monitoring using electrical impedance tomography. During capnoperitoneum, the thoraco-abdominal configuration changes with confounding effects of the diaphragm on the EIT image. This may reduce the use of this method during laparoscopic surgeries. For this reason, the authors assume that for lung monitoring using EIT during capnoperitoneum, the manufacturer's recommendation of electrode belt position are unsuitable.

Comparison of lymphatic vessel density and expression of VEGF-C and VEGF-D lymphangiogenic factors in Warthin's tumours and oncocytic adenomas

Jiri Hoza, Richard Salzman, Tomas Bakaj, Ladislava Kucerova, Ivo Starek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):47-53 | 10.5507/bp.2017.048

There has been much recent attention on tumoral lymphangiogenesis. Relevant information on malignant salivary gland tumors is very limited and virtually non existent on benign forms. The presented paper demonstrates that Warthin“s tumor but not other benign salivary adenomas is rich in stromal lymphatics. This difference is due to lymphoid stroma in the former lesion, producing major lymphangiogenic factors.

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

Marek Handl, Marketa Hermanova, Sylva Hotarkova, Jiri Jarkovsky, Peter Mudry, Tetiana Shatokhina, Marcela Vesela, Jaroslav Sterba, Iva Zambo

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):54-60 | 10.5507/bp.2017.049

In Ewing sarcoma, little is known about molecular markers that could be used for prognostic risk stratification at the time of diagnostic biopsy, i.e. prior to treatment. This is the first study to quantify CD163 expression in tumor-associated macrophages (TAMs) in Ewing sarcoma. This study found an association between CD163 expression and lower ES stage. The results suggest a possible relationship between markers of TAMs and prognosis of patients with Ewing sarcoma. The authors believe that more detailed information about TAMs could contribute to a better understanding of the biological behavior of this sarcoma.

The application of volumometry as an indication criterion in blow-out fractures

Daniel Kovar, Richard Holy, Zdenek Voldrich, Pavel Voska, Jan Lestak, Jaromir Astl

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):61-64 | 10.5507/bp.2017.037

The authors used a mathematical model to calculate the volume of prolapsed soft tissue of the orbit in blow-out fractures of the orbital floor as an indication criterion for treatment. In cases orbital floorfractures we can identify immediately, post-trauma patients requiring surgical treatment. This method helps us avoid incorrect treatment indications, conservative or surgical.

Case report

Acute lymphoblastic leukemia in a child with Leri-Weill syndrome and complete SHOX gene deletion: A Case Report

Jana Volejnikova, Jirina Zapletalova, Marie Jarosova, Helena Urbankova, Petr Vojta, Eva Klaskova, Marshall S. Horwitz, Marian Hajduch, Vladimir Mihal

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018, 162(1):65-70 | 10.5507/bp.2018.002

The authors present a rare case of an 11-year-old female followed after successful treatment of acute lymphoblastic leukemia (ALL), who was incidentally diagnosed with inherited Leri-Weill syndrome (LWS) with complete deletion of the SHOX gene. The authors underline the necessity of growth assessment in pediatric hemato-oncologic patients, in whom growth delay is not always a side effect of chemotherapy, but may be caused by an independent concurrent condition. A comprehensive review of the literature is provided.