Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):461-466 | 10.5507/bp.2016.052
This review evaluates the role of dysbiosis and related oxidative stress in the pathogenesis of chronic inflammatory bowel diseases. It also assesses the impact of diet on dysbiosis.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):467-473 | 10.5507/bp.2016.037
Glycoprotein asporin has unique functions that affect tumor microenvironments and cancer progression. Current contradictory results on tumour promoting and suppressive effects of asporin require further investigation, in particular with respect to aspartic acid repeat polymorphism.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):474-483 | 10.5507/bp.2016.036
This review outlines the role of hybrid SPECT/CT imaging as a powerful modality for skeletal and nodal staging in breast cancer patients with a major impact on therapy. Development of new generation SPECT/CT systems and their introduction into practice has changed the old diagnostic algorithm.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):484-490 | 10.5507/bp.2016.058
The multidisciplinary management of secondary brain tumors is a real challenge for neuro-oncological teams. This review provides a summary of the literature on treatment approaches and modalities in this setting in order to simplify decision-making by treating physicians.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):491-494 | 10.5507/bp.2016.049
Publications have consistently shown that interlobar fissures exhibit high variability and that preoperative or at least detailed perioperative assessment can influence treatment results in patients. This article provides a comprehensive review of the prevalence of incomplete interlobar fissures assessed by various methods: imaging techniques, endobronchial methods measuring collateral air flow, perioperative view and autopsies.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):495-498 | 10.5507/bp.2016.038
Described in this paper is a rare familial case of congenital central hypoventilation syndrome associated with heterozygous in frame polyalanine repeat expansion mutation in the PHOX2B gene (casual mutation c.741_755dup15 in exon 3 of PHOX2B) proven in 2/3 clinically impaired family members. The significant clinical variability in patients with the identical PHOX2B gene mutation is discussed. In addition, the authors summarise previously reported at least three-generation familial cases with a late-form of CCHS and proven PHOX2B mutation.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):499-502 | 10.5507/bp.2016.041
This study provides novel insights into procalcitonin (PCT) measurement in an extremely vulnerable population and highlights a new hypothesis on the inflammatory process during pregnancy. Changes in maternal, umbilical and neonatal PCT values suggest its production and release by fetal tissue. This hypothesis needs be confirmed in future research.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):503-511 | 10.5507/bp.2016.050
The authors have developed a modification of the McRAPD strain typing technique that relies on statistical evaluation of significant differences between bacterial isolates. Because of rapid performance and potential for automation, this technique is a suitable candidate for routine use in clinical microbiology. Using the model of H. influenzae recovery in chronic lung disease they demonstrated that repeated recovery of the same species at distant time-points represents infection by a new strain in up to 70% of cases and thus should not be underestimated as a mere persisting long-term colonisation.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):512-517 | 10.5507/bp.2016.046
Magnetic resonance cholangiopancreatography (MRCP) is often used for imaging the biliary tree. Advanced liver cirrhosis and ascites however present diagnostic problems for MRCP and for surgeons during liver transplantation. MRCP for diagnosis of the extrahepatic biliary tree in liver cirrhosis has not been tested properly. Application of negative per-oral SPIO contrast agent before MRCP improves the visualization of extrahepatic biliary ducts in patients with liver cirrhosis and ascites.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):518-523 | 10.5507/bp.2016.025
The main objective of the study was to investigate the impact of antibodies against Angiotensin II Type 1 Receptor (AT1R) associated with the use of Left Ventricular Assist Devices (LVAD) on the survival and complications of supported patients. The results failed to show an association between AT1R antibodies and adverse outcomes in LVAD recipients. The study was hampered by limitations inherent in a retrospective single centre analysis and small sample size. The authors believe that with a larger patient population may be able to show a significant difference in outcomes of mechanically bridged patients stratified by the presence of anti-AT1R antibodies and that these antibodies may prove to be a valuable tool in a risk assessment of LVAD patients.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):524-532 | 10.5507/bp.2016.033
This study focused on the differences between patients with biopsy-proven inflammatory cardiomyopathy with and without improved left ventricular systolic function. Although a higher number of inflammatory cells at baseline and more pronounced decline to follow-up biopsy were observed in the group with improved ejection fraction of the left ventricle, supporting the hypothesis that initial more intense inflammatory changes lead to more rapid retreat of myocardial inflammation and is associated with improved left ventricular function, in the multivariate analysis only NTproBNP level at baseline was confirmed as an independent predictor of improved ejection fraction of the left ventricle.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):533-537 | 10.5507/bp.2016.051
The accuracy of postnatal CT was compared with histopathological findings in 24 children with bronchopulmonary malformation (BPM). Chest CT with intravenous contrast agent administration in patients with BPM is accurate for the detailed evaluation of the morphologic substrate of congenital lung pathology.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):538-542 | 10.5507/bp.2016.055
The authors investigated whether expression of MMP-2, MMP-8, MMP-9, TIMP-2, and TIMP-4 is dysregulated in children with CLP. Greater expression of MMP-2 and TIMP-2 in CLP patients than in controls was found. The results of this study suggest that TIMP-4 and MMP-9 are the main ECM remodeling regulatory proteins expressed in CUCLP affected tissues of the oral mucosa.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):543-548 | 10.5507/bp.2016.042
This was a pilot study that compared the safety and efficacy of heparin or nadroparin to placebo administered to patients with acute ischemic stroke. The study showed that both heparin and nadroparin treatments are safe in comparison to placebo and they are also effective in the acute phase of ischemic stroke. However, it is necessary to confirm the findings with multicentric clinical trials and larger numbers of patients.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):549-552 | 10.5507/bp.2016.023
The authors report on an open- label clinical study on the efficacy of rasagiline as an add-on therapy on freezing of gait and quality of life in patients with Parkinson's disease. Rasagiline added to antiparkinson therapy in patients with freezing of gait showed significantly improved mobility, freezing of gait and quality of life. The effect on freezing of gait appears to be related to dopaminergic action on mobility.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):553-558 | 10.5507/bp.2016.032
This study contributes to quantification of the genotoxic risk of therapeutic exposure to polycyclic aromatic hydrocarbons and UV-radiation (Goeckerman therapy of psoriasis). To assess the level of genotoxic effects, Comet assays and chromosomal aberrations in peripheral lymphocytes were used. Significantly elevated levels of DNA double strand breaks (DNA-DSBs) and chromosomal aberrations (total number of aberrated chromosomes and structurally aberrated chromosomes) indicated the presence of genotoxic hazard. However, the elevated level of chromosomal abnormalities was below the upper limit of the reference range for healthy Czech adults. In summary, the level of genotoxic risk appears to be low. On the other hand, it is evident that Goeckerman therapy contributes to the lifetime load of genotoxic factors.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):559-565 | 10.5507/bp.2016.056
Four week cranberry fruit powder intake before prostatectomy in men modulates serum PSA.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):566-570 | 10.5507/bp.2016.048
This article describes a surgical technique using the anterior mini-invasive approach (mini-thoracotomy) with thoracoscopy.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):571-577 | 10.5507/bp.2016.040
This study showed that local anesthesia used for dental extraction was of shorter duration, and that dissipation of the anesthetic field was more rapid in patients taking cardiovascular drugs. Such results were not observed previously, and finding that drugs acting on cardiovascular system may influence the effect of local anesthetics used in dentistry, possibly through interaction at autonomic receptors and ion channels, could be of practical significance when planning interventions under local anesthesia in dentistry.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):578-582 | 10.5507/bp.2016.045
Although uncommen in children, most pediatric bladder cancers are low grade, low stage urothelial cancer. The authors present an extremely rare case of high grade cancer with osseous metaplasia in a 3-year old boy treated by transurethral resection without adjuvant intravesical chemotherapy. For differential diagnostic purposes, typical characteristics of urothelial papilloma, carcinoma, nephrogenic adenoma and hamartoma are included with an overview of follow-up recommendations.