Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(2):166-171 | DOI: 10.5507/bp.2018.043

Association of serum adipocyte fatty acid-binding protein and apolipoprotein B /apolipoprotein A1 ratio with intima media thickness of common carotid artery in dyslipidemic patients

Jiri Orsaga, David Karaseka, Milan Halenkaa, Helena Vaverkovaa, Jaromira Spurnaa, Veronika Kubickovab, Jiri Lukesb, Josef Zadrazila
a Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
b Department of Clinical Biochemistry, University Hospital Olomouc, Czech Republic

Background: Diseases caused by atherosclerosis play the most important role in mortality and morbidity worldwide. Serum adipocyte fatty acid binding protein (A-FABP) seems to be a new promising marker to determine the risk of atherosclerosis.

Objective: The aim of this study was to evaluate relationships between serum A-FABP levels in studied individuals and to assess the possibility of modeling the intima media thickness of the common carotid artery (C-IMT) using A-FABP levels and other observed characteristics.

Methods: Seventy two Caucasian individuals were enrolled and divided into 3 groups: dyslipidemic patients with or without metabolic syndrome (MetS+, n=17; MetS-, n= 34) and controls (n=21).

Results: There was confirmed the well-established risk profile of individuals with MetS (unfavorable lipid and lipoprotein profile, as well as increased parameters of insulin resistence and C-IMT). A-FABP concentrations in this group were significantly higher in comparison with both MetS- and controls.

Conclusion: Using multiple linear regression models of C-IMT values for all individual data, healthy controls and dyslipidemic patients without metabolic syndrome (MetS-) A-FABP levels were not revealed as an important predictor of C-IMT in our model. In contrast, age, gender, waist circumference, nonHDL cholesterol levels and ApoB/ApoA1 ratio were important repressors of C- IMT in study individuals. This finding may be attributed to the overwhelming effect of other more robust risk factors for atherosclerosis in these individuals.

Keywords: adipocyte fatty acid binding protein, intima media thickness, dyslipidemia

Received: April 8, 2018; Accepted: July 19, 2018; Prepublished online: September 11, 2018; Published: June 25, 2019  Show citation

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Orsag, J., Karasek, D., Halenka, M., Vaverkova, H., Spurna, J., Kubickova, V., Lukes, J., & Zadrazil, J. (2019). Association of serum adipocyte fatty acid-binding protein and apolipoprotein B /apolipoprotein A1 ratio with intima media thickness of common carotid artery in dyslipidemic patients. Biomedical papers, 163(2), 166-171. doi: 10.5507/bp.2018.043
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