Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(4):394-400 | DOI: 10.5507/bp.2019.033

Prediction Score for persisting perfusion defects after pulmonary embolism

Jan Mrozeka, Tereza Necasovab, Michal Svobodab, Iveta Simkovac, Pavel Jansad
a Department of Cardiovascular Diseases, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic
b Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University Brno, Postovska 68/3, 602 00 Brno, Czech Republic
c National Institute of Cardiovascular Diseases and Slovak Medical University, Pod Krasnou horkou 7185/1, 831 01 Bratislava - Nove Mesto, Slovak Republic
d Clinical Department of Cardiology and Angiology, 1st Faculty of Medicine, 2nd Medical Department, Charles University, U Nemocnice 499/2, 128 08 Praha 2 - Nove Mesto, Czech Republic

Aims: Long-term persistence of perfusion defect after pulmonaryembolism (PE) may lead to the development of chronic thromboembolic pulmonary hypertension. Identification of patients at risk of such a complication using a scoring system would be beneficial in clinical practice. Here, we aimed to derive a score for predicting persistence of perfusion defects after PE.

Methods: 83 patients after PE were re-examined 6, 12 and 24 months after the PE episode. Data collected at the time of PE and perfusion status during follow-ups were used for modelling perfusion defects persistence using the Cox proportional hazards model and validated using bootstrap method.

Results: A simple scoring system utilizing two variables (hemoglobin levels and age at the time of PE) was developed. Patients with hemoglobin levels over 140 g/L who were older than 65 years were at the highest risk of perfusion defects; in patients with the same hemoglobin levels and age <65 years, the risk was reduced by 79%, and by 89% in patients with hemoglobin <140 g/L.

Conclusion: The proposed scoring system may be useful in clinical practice for identifying patients with high risk of persisting perfusion defects, flagging them for closer follow up, thus improving the effectiveness of long-term treatment of patients after PE.

Keywords: pulmonary embolism, prediction score, perfusion defects, reperfusion, risk score, classification

Received: May 26, 2019; Revised: June 4, 2019; Accepted: July 2, 2019; Prepublished online: September 13, 2019; Published: December 15, 2020  Show citation

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Mrozek, J., Necasova, T., Svoboda, M., Simkova, I., & Jansa, P. (2020). Prediction Score for persisting perfusion defects after pulmonary embolism. Biomedical papers, 164(4), 394-400. doi: 10.5507/bp.2019.033
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