Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025, 169(2):82-90 | DOI: 10.5507/bp.2024.034

Meta-analysis study on anesthetic sedation recovery and onset times in pediatric and elderly patients undergoing CT and MRI

Qiong Zhao1, Fei Meng2, Huimei Han2, Lili Han1
1 Department of Anesthesiology, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan City, 250013 Jinan, P. R. China
2 Department of Anesthesiology, Jinan Third People's Hospital, No. 1 Wangsheren North Street, Gongye North Road, Licheng District, Jinan City, Shandong Province, 250132, P. R. China

Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are crucial diagnostic modalities that require patients to remain immobile for extended periods, with anesthesia sometimes used for comfort and image quality enhancement. The study compares dexmedetomidine and propofol in reducing recovery time and sedation onset in pediatric and elderly patients undergoing CT and MRI procedures. A meta-analysis of fifteen studies assessing recovery time, sedation onset, and failed sedation between dexmedetomidine and propofol in pediatric and elderly patients during CT and MRI was conducted. The study indicated that the administration of anaesthesia markedly improved patient compliance and reduced motion artefacts in both CT and MRI (P<0.00001, I2=94%). The meta-analysis indicated that the mean difference (MD) in the onset of sedation was significantly faster in the control group (P<0.00001, I2=96%). The study reveals that dexmedetomidine and propofol anesthesia can improve patient image quality during CT and MRI procedures by reducing motion artefacts. Dexmedetomidine sedated people more quickly than propofol, but no significant differences in sedation duration were observed.

Keywords: anesthesia, elderly patients, pediatric patients, propofol, dexmedetomidine, CT scan, meta-analysis, recovery time

Received: June 25, 2024; Revised: September 24, 2024; Accepted: October 11, 2024; Prepublished online: November 1, 2024; Published: June 1, 2025  Show citation

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Zhao, Q., Meng, F., Han, H., & Han, L. (2025). Meta-analysis study on anesthetic sedation recovery and onset times in pediatric and elderly patients undergoing CT and MRI. Biomedical papers, 169(2), 82-90. doi: 10.5507/bp.2024.034
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