Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):277-282 | DOI: 10.5507/bp.2014.063

The effect of continuous positive airway pressure therapy on the prevalence of masked hypertension in obstructive sleep apnea patients

Milan Sovaa, Eliska Sovovab, Milada Hobzovaa, Jana Zapletalovac, Monika Kamasovab, Vitezslav Koleka
a Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
b Department of Internal Medicine I - Cardiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc
c Department of Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc

Background and Aim. Obstructive sleep apnea (OSA) is a common cause of secondary arterial hypertension. Masked hypertension (MH) is defined as normal office blood pressure and abnormal results in 24 h ambulatory blood pressure monitoring (ABPM). The aim of this study was to evaluate the effect of CPAP therapy on the prevalence of MH in patients with OSA.

Methods: 43 patients (40 men) were included, average age 54.2±10.5 years. All underwent sleep study (PG or PSG) with a diagnosis of OSA indicated for CPAP treatment, average apnea-hypopnea index (AHI) 60.6±23.6. Patients were treated with CPAP for one year. Ambulatory blood pressure monitoring was performed before and after one year of treatment.

Results: Masked hypertension was initially present in 25 (58.1%) and in 26 (60.5%) patients after one year of CPAP therapy. However, there was a statistically significant improvement in BP for all evaluated intervals of ABPM with the exception of systolic pressure during the daytime.

Conclusions: Masked hypertension was very prevalent in these patients with OSA. The CPAP treatment for one year however had no affect on prevalence of masked hypertension although there was a positive effect of CPAP treatment on blood pressure for all assessed intervals of ABPM with the exception of systolic BP during daytime.

Keywords: masked hypertension, obstructive sleep apnea, continuous positive airway pressure, ambulatory blood pressure monitoring

Received: June 10, 2014; Accepted: November 18, 2014; Prepublished online: December 22, 2014; Published: June 28, 2015  Show citation

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Sova, M., Sovova, E., Hobzova, M., Zapletalova, J., Kamasova, M., & Kolek, V. (2015). The effect of continuous positive airway pressure therapy on the prevalence of masked hypertension in obstructive sleep apnea patients. Biomedical papers, 159(2), 277-282. doi: 10.5507/bp.2014.063
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