Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):166-177 | 10.5507/bp.2015.025
Adaptation to hypoxia requires many genetic and biochemical responses that mutually regulate one another. Hypoxia-induced resistance is consequently very complex. The most studied factor responsible is hypoxia-inducible factor-1 (HIF-1) that significantly contributes to the aggressiveness and chemoresistance of various tumours. Also described are HIF-1 independent mechanisms of drug resistance in hypoxic tumours. Since hypoxia is closely associated with chemo- and radio resistance, different approaches have been developed to circumvent hypoxia-induced resistance.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):178-183 | 10.5507/bp.2013.092
A review of the the literature has revealed the presence of a field with genetically altered cells that appear to be induced by tobacco (smoking/smokeless form). A large number of premalignant cells in the fields, may increase cancer risk.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):184-191 | 10.5507/bp.2014.037
Two sides of the miRNA29 family. Are they suppressors or promoters in hematooncology?
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):192-196 | 10.5507/bp.2014.061
This paper summarises recent evidence on of the structure and functions of tissue factor. It covers the role of tissue factor and its inhibitor in blood coagulation, the inflammatory response, angiogenesis and cell migration. The paper is specifically aimed at the role of tissue factor in the uteroplacental vessel network during physiological pregnancy and pregnancy complicated by preeclampsia
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):197-202 | 10.5507/bp.2013.093
This paper focuses on current knowledge of the pathophysiology of anemia in CKD. It provides details on the physiology and pathophysiology of erythropoietin and iron metabolism in CKD and briefly discusses other known factors which may be important for the development of renal anemia. Understanding the pathophysiology of anemia in CKD is crucial for optimal management of anemia. Changes in treating anemia in patients with CKD which have created new recomendations (KDIGO, 2012) to the American (KDOQI, 2006) and European (ERBP, 2004) are summarized.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):203-207 | 10.5507/bp.2013.018
Intermittent claudication in patients with long occlusion of the femoropopliteal segment is mainly treated conservatively but if this fails, a form of revascularization is indicated. The revascularization is currently achieved using two basic methods : surgical bypass or mini invasively by endovascular procedures. The authors compare the two approaches in order to to answer the question whether surgical bypass is still the best method of choice in an era of endovascular techniques.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):208-214 | 10.5507/bp.2014.060
There is large body of evidence of metabolic syndrome development as a consequence of antipsychotic treatment in schizophrenic patients. However, recently the schizophrenic phenotype per se was proven to contribute to the metabolic distortions. Similarly, this connection has been reported in depressed patients. This review maps inflammatory pathology as a common underlying cause of metabolic syndrome and psychiatric comorbidities. The paper also assesses possible gender differences.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):215-219 | 10.5507/bp.2013.072
Mesenchymal stromal cells (MSC) exhibit an immunomodulatory potential in patients with graft versus host disease following allogeneic hematopoietic stem cell transplantation. The immunosuppressive function of MSC was examined by coculturing them with stimulated HLA incompatible allogeneic lymphocytes in a mixed lymphocyte culture test. The presence of MSC caused significant decrease in the metabolic and proliferative activity of lymphocytes. The absorbance levels determined with MTT test decreased by 62% (P<0.01), 26% (P<0.01) and 6% (P=0.0437) in comparison to positive controls depending on the MSC/lymphocyte ratio (1:5, 1:50, 1:500). The experiments confirmed the dose-dependent inhibitory effect of MSC on lymphocyte proliferation triggered by stimulation with alloantigens.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):220-226 | 10.5507/bp.2015.012
Melatonin can reduce the expressions of AQP4 and GFAP in rat spinal cord tissue and inhibit edema after spinal cord injury. Melatonin provides fairly good protection and treatment for spinal cord injury in rats.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):227-233 | 10.5507/bp.2014.045
This paper describes research based on quantum dots between human amniotic membrane mesenchymal stem cells. The observed compatibility of the two and the changes in cell growth, provide a new approach to cell markers
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):234-241 | 10.5507/bp.2014.038
This paper describes a palliative treatment of recurrent malignant pleural effusion by powdered talc using thoracoscopy. The talc- induced pleurodesis is a result of an inflammatory reaction in both pleural membranes. The paper presents the original results of selected systemic and local manifestations of the talc-induced inflammatory reaction (serum and pleural effusion CRP levels, local expression of membrane receptors TLR-2 and CD-64 on granulocyte and monocyte cell populations in the pleural effusion).
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):242-245 | 10.5507/bp.2014.036
Helicobacter pylori (H. pylori) infection is a common health problem worlwide. Eradication of H. pylori results in lower rates of complications related to peptic ulcer disease. In this study, eradication of H. pylori was found to have favorable effects on insulin resistance and HbA1c levels in people with normal glucose levels.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):246-250 | 10.5507/bp.2015.030
In this study, the authors provide their own data of the currently controversial renal denervation procedure: recent results from Symplicity HTN-3 showed no statistically significant difference between renal denervation and sham procedure in blood pressure lowering. The data do not confirm any other other positive effect of renal denervation for treating insulin resistance/diabetes mellitus 2. type. To date, there is no recommendation for the use of renal denervation in the treatment of resistant hypertension in routine clinical practice.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):251-258 | 10.5507/bp.2014.003
Pre-infarction unstable angina pectoris (UAP) can be considered ischemic preconditioning. The aim of this study was to compare short and long term outcomes in patients (N=593) with (N=205) or without pre-infarction UAP (N=388) and ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). In patients with STEMI treated with primary PCI, pre-infarction UAP has no beneficial clinical effect during hospitalization or during long-term follow-up.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):259-265 | 10.5507/bp.2013.082
The aim of this study was to assess the clinical benefit of several parameters measured from CT pulmonary angiography. Their relation to clinical outcome - administration of thrombolytic therapy and to other currently used methods (biomarkers,echocardiography) were studied. The statistical analysis, showed the RV/LV diameter ratio measured from CT images was the most valid parameter.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):266-271 | 10.5507/bp.2014.039
This article describes the role of eosinophils in predicting the formation of thrombus in non ST-segment elevated myocardial infarction (NSTEMI). Thrombus formation has frequently been reported as the most crucial contributing factor in ST-segment elevated MI. In this study the authors show that this crucial factor should not be disregarded in NSTEMI patients either.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):272-276 | 10.5507/bp.2013.091
This prospective clinical study showed that in patients who were treated with percutaneous coronary intervention following ST elevation myocardial infarction, serum levels of procollagen type I carboxyterminal peptide (PICP) and procollagen type III peptide (PIIINP) are predictive of outcome within 12 months of treatment.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):277-282 | 10.5507/bp.2014.063
This was a study of the effect of continuous positive airway pressure (CPAP) on the prevalence of masked hypertension in Obstructive Sleep Apnea patients. Masked hypertension is very prevalent in these patients and CPAP could be effective in blood pressure lowering. However this study nopositive effect of CPAP on the prevalence of masked hypertension was found
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):283-287 | 10.5507/bp.2015.019
The cause of cryptogenic ischemic stroke in younger patients often remains obscure- -. In elderly patients with cryptogenic stroke, paroxysmal atrial fibrillation (AF) is a frequent cause of stroke. Thus, undetected paroxysmal AF is considered a possible cause in young patients as well. However insufficient relevant data on the incidence of paroxysmal AF are available in this stroke population. This article reports the rate of detected paroxysmal AF in young cryptogenic ischemic stroke patients ≤ 50 years using long-term ECG Holter monitoring.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):288-293 | 10.5507/bp.2015.014
Extramedullary relapse of multiple myeloma is slowly becoming a new challenge in the treatment of multiple myeloma patients. It appears that extramedullary relapse may be characterized by a clone of plasma cells that accumulate more genomic abnormalities allowing these cells to survive outside the bone marrow.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):294-298 | 10.5507/bp.2013.086
Acute promyelocytic leukemia is the most curable subtype of adult acute leukemias. Fatal bleeding complications occur at diagnosis or during the induction part of treatment and remain a major cause of death. The authors report a case of a very rare spontaneous splenic rupture as a complication of initial antileukemic treatment in a patient with the highest risk of fatal bleeding, according to prognostic factors.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):299-301 | 10.5507/bp.2014.051
This paper compares serum levels of 17 cytokines and 5 adhesion molecules in patients with newly diagnosed AML and ALL using biochip array technology. The authors found significant increase in AML in serum IL-4, IL-2, IL-3, and significant decrease in serum VEGF and VCAM-1. The results show that the serum profile of cytokines and adhesion molecules differs in newly diagnosed AML and ALL patients.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):302-306 | 10.5507/bp.2014.062
It is the largest study on autoimmunity in PCOS patients with the widest spectrum of non organ specific autoantibodies to be examined to date. The authors found that the prevalence of non organ-specific autoantibodies in PCOS women was very low and similar or even lower than in healthy controls. They also found a slightly higher prevalence of thyroid autoimmuinity in PCOS women but this finding may have been related to the metabolic syndrome rather than to PCOS alone.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):307-312 | 10.5507/bp.2014.001
This study on a large cohort of patients showed that the B-scan ultrasonographic measurement of horizontal eye muscles thickness in patients with thyroid-associated orbitopathy moderately correlates with values obtained using magnetic resonance imaging. The study confirmed that ultrasound is a very useful diagnostic tool for routine clinical practice in evaluation patients with thyroid-associated orbitopathy. The accuracy of ultrasonographic measurements significantly increases with the experience of the investigator.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):313-317 | 10.5507/bp.2013.069
Bisphosphonate-related osteonecrosis of the jaw is a rare but severe side-effect of bisphosphonate use. This article summarizes the author's experience with the diagnosis and treatment of bisphosphonate-related osteonecrosis of the jaw during the years 2006-2012.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):318-326 | 10.5507/bp.2013.083
This is the first study, to the knowledge, of the authors to examine post-sympathectomy dysfunction objectively, using thermography after anterior or lateral interbody fusion of the lumbar spine (ALIF, XLIF) procedures, and the first study to evaluate clinically the severity of the post-sympathectomy syndrome!
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):327-332 | 10.5507/bp.2013.081
The cutaneous silent period (CSP) is a spinal inhibitory reflex primarily mediated by A-delta fibers. In this study, the observed CSP prolongation concurred with previous findings in idiopathic Parkinson's disease (IPD). The lack of effect of levodopa on CSP abnormalities may aid in the differential diagnosis of multiple system atrophy versus IPD.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):333-337 | 10.5507/bp.2015.003
This paper describe a patient with a rare chromosomal aberration - a pure de novo subtelomeric 17p13.2-pter duplication. Despite known facial features, the proband presented with oculocutaneous albinism which has not been reported previously. The authors discuss in detail the genotype-phenotype correlations of the aberration as well as the possible molecular etiology of albinism apropos the mode of inheritance.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):338-340