Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):vi
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):001-011 | 10.5507/bp.2014.049
Adhesive interactions are vital for the persistence of both normal and malignant cells. Malignant cells trigger positive feedback loops causing adhesion molecule inflammatory overexpression. Disruption of adhesive interactions can overcome the high resistance to treatment and increase the selectivity of malignant cell targeting. Understanding adhesive interactions may underlie the basis of novel therapeutic approaches.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):012-017 | 10.5507/bp.2013.076
The extracellular matrix (ECM), which can be variously obtained, has several advantages such as providing the proper environment for cell attachment and proliferation. Decellularization techniques are very promising: they remove cell components, preserve tissue ECM and provides an optimal 3D environment for tissue engineering. This review covers chemical agents that are most widely used in decellularization methods.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):018-026 | 10.5507/bp.2014.046
This review provides current insight into the clinical uses of Prostate Specific Antigen with focus on the controversies and future perspectives of this biomarker and including a summary of the latest research in this field.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):027-030 | 10.5507/bp.2014.027
Venous anastomosis closure of arteriovenous graft (AVG) for hemodialysis leads to complete closure of AVG and loss of funtion. This article summarizes the evolution of the treatment of this complication. Currently preferred are endovascular and hybrid procedures.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):031-034 | 10.5507/bp.2013.026
Arthrocentesis of the temporomandibular joint is a minimally invasive method for treatment thatborders the conservative and the surgical. The main objectives of arthrocentesis are to wash out inflammatory mediators, release the disc, break adhesions, eliminate pain and improve joint mobility. It has become widespread and very popular in the treatment of internal disorders of the temporomandibular joint.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):035-043 | 10.5507/bp.2013.020
Therapeutic drug monitoring is a specific method of clinical pharmacology for monitoring drugs, using the measurement of drug serum concentrations followed by interpretation and good cooperation with clinician. It facilitates personalized medicine as dosing as rational therapy, minimising side effects, reducing negative consequences and cost of health care. Phenotyping and genotyping can improve monitoring of antidepressant drugs.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):044-052 | 10.5507/bp.2013.089
This is a review on delirium tremens, the most severe complication of alcohol withdarawal and focused on pathogenesis, clinical symptoms, complications and proper, current management.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):053-059 | 10.5507/bp.2013.096
This research article explores the impact of puerarin in the pathogenesis of atherosclerosis in experimental atherosclerotic rabbits. The findings were that puerarin significantly attenuated the initiation and development of atherosclerotic lesions. Puerarin had anti-atherosclerotic effects through decreased expression of proliferating cell nuclear antigen (PCNA) and platelet-derived growth factor A (PDGF-A). In this way, puerarin attenuated the migration and proliferation of vascular smooth muscle cells (VMSCs).
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):060-066 | 10.5507/bp.2014.052
This study elucidates the preclinical in vivo behaviour of selected 68Ga labelled siderophores versus radiochemical impurities, which can develop during 68Ga labelling and 68Ga-citrate as a representative of clinically used infection imaging agents. 68Ga-siderophores show great promise as highly selective, highly sensitive tracers for Aspergillus infection imaging. For translation into clinical practice more data on the pharmacokinetics and biodistribution of these promising new tracers are warranted.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):067-076 | 10.5507/bp.2012.115
Samples of coladerm-beta glucan membrane (CBGM) were prepared using atelocollagen Hypro-Sorb®. Its biocompatibility, cytotoxicity, antimicrobial activity, genotoxicity and mutagenicity were then evaluated in vitro. The results show that the CBGM has good biocompatibility, antibacterial activity, no cytotoxicity/ genotoxicity/ mutagenicity and can be included as a potential scaffold for tissue engineering.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):077-082 | 10.5507/bp.2013.007
The potent antioxidant - carotenoid lycopene had positive effect at the level of oxidative stress in seminal plasma of males incases of infertile couples. There was an improved ratio of two polyunsaturated fatty acids - arachidonic acid and docosahexaenoic acid. Although there were no significant changes in semen parameters, there wasincreased chance for achieving spontaneous conception as well as likelihood of pregnancy after IVF treatment.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):083-086 | 10.5507/bp.2013.097
Curvelet based noise removal and a new segmentation method not tried before were tested for the detection of breast cancer. The results were better than existing methods.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):087-092 | 10.5507/bp.2012.104
The presence of metallic particles in pathologically altered tissues may signal an alternative causation of some diseases. The ethiopathogenic explanation of the diseases associated with the presence of nano-sized particles in the organism is emerging as a new field of pathology, nanopathology.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):093-099 | 10.5507/bp.2013.087
Patients with chronic kidney disease have significant disorders in bone and mineral metabolism. This study evaluated the bone mineral density (BMD) of patients at the start of hemodialysis treatment and the relationship between BMD and possible risk factors or biochemical markers.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):100-103 | 10.5507/bp.2014.042
The ESBL- and AmpC-positive Enterobacteriaceae in the normal gastrointestinal tract (GIT) microflora are potential etiological agents whose high resistance to antibiotic treatment can lead to a failure of initial antibiotic therapy. Some authors do not consider monitoring of these strains as useful. However, our study identified two patients diagnosed with urinary tract and bloodstream infections caused by ESBL- or AmpC-positive Enterobacteriaceae from the GIT microflora. This is evidence that these strains can act as agents causing bacterial complications and in patients with hematological malignancies, it is advisable to regularly monitor the prevalence of both pathogenic multiresistant strains and potentially pathogenic strains found in GIT.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):104-113 | 10.5507/bp.2014.058
The sensitivity and specificity of CSF-restricted oligoclonal IgG and oligoclonal free light chains are compared for the ability to diagnose multiple sclerosis and other inflammatory neurological diseases. Optimal cut-off values for the number of CSF-restricted oligoclonal IgG and free light chain bands were analyzed; for oligoclonal IgG and free light chains, these cut-offs were found to be higher (≥4 IgG bands and ≥6 free κ bands) than the cut-off ≥2 bands usually reported so far. The general conclusion is that reporting borderline values as positive, compromises the specificity of these tests. The oligoclonal free light chain test may be valuable especially when the oligoclonal IgG test is negative or borderline.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):114-119 | 10.5507/bp.2013.016
Seventy-one patients at risk of heart failure with normal left ventricular ejection fraction underwent simultaneous exercise echocardiography and right heart catheterization. Fifty-one patients had exercise-induced pulmonary capillary wedge pressure (PCWP) elevation ≥ 8 mmHg and reached peak exercise PCWP ≥ 20 mmHg. Post-exercise recovery of PCWP at 1, 2, 3, 4, and ≥ 5 min was achieved in 7 (13.7%), 11 (21.6%), 10 (19.6%), 6 (11.8%), and 17 (33.3%) patients, resp. In summary, the course of post-exercise PCWP recovery is highly variable, and a significant proportion of patients have only a brief period (≤ 2 min) of exercise-induced PCWP elevation. This fact should be taken into account when assessing exercise-induced PCWP noninvasively.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):120-123 | 10.5507/bp.2013.015
In the treatment of central serous chorioretinopathy, we used the beta-blocker metipranolol. Metipranolol use is associated with possible adverse effects such as: indigestion, fatigue, weakness, malaise, headache, dizziness, insomnia, depression, itching, skin rash, visual disturbances, shortness of breath, slow heart rate and other heart rhythm disorders, low blood pressure , dryness of the conjunctiva. This study showed no benefit of metipranolol for the treatment of central serous chorioretinopathy. We believe that metipranolol is not appropriate for the treatment of patients with central serous chorioretinopathy, exposing them to the risk of the adverse events associated withmetipranolol.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):124-130 | 10.5507/bp.2013.044
Patients with chronic heart failure (HF) need self-care training to integrate their health problem into everday life. The article maps the level of patients' problems and level of self-care actions performed by patients with HF.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):131-134 | 10.5507/bp.2013.012
This paper compares the impact of retransfusing patient's blood processed in cell-saver and cardiopulmonary bypass on hemocoagulation. The authors analyzed thromboelastographic (TEG) samples from 170 patients who had undergone cardiac surgery with and without cardiopulmonary bypass. The results show similar effects to hemocoagulation in cardiac patients.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):135-138 | 10.5507/bp.2014.008
Proliferation is an independent prognostic factor in multiple myeloma. Increased activity of thymidine kinase in serum is associated with higher proliferation rate in multiple myeloma. Imaging methods such as 99mTc-MIBI scintigraphy and 18F-FDG PET/CT imagine active myeloma lesions and a positive result is a negative prognostic factor. Increased levels of serum thymidine kinase were observed in MIBI or PET/CT positive patients.Combination of increased levels of serum thymidine kinase and positive MIBI or PET/CT results are useful prognostic factors.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):139-144 | 10.5507/bp.2014.054
This retrospective analysis summarizes single-center experience with hepatic arterial infusion (HAI) in hepatocellular carcinoma (HCC). Published experience with HAI in HCC in Western countries is sparse, and the present data demonstrate limited efficacy of this therapeutic approach.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):145-149 | 10.5507/bp.2013.080
To the best of our knowledge, this is the first report in the study of the impact of modifier gene in the occurrence of osteonecrosis in sickle cell anemia in Tunisian patients. Significant associations with osteonecrosis were found with 2 SNPs namely: rs267196 and rs267201 of BMP6 gene.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):150-155 | 10.5507/bp.2013.052
This is the first prospective study that compares the results (neurological deterioration, overall survival time) of resection and biopsy of glioblastoma (GBM) in eloquent brain areas (EBA). For patients in good clinical condition and for tumors in or near EBA, resection of the GBM (as radical as possible) is recommended.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):156-162 | 10.5507/bp.2013.046
The paper describes the variables that can complicate compliance and decision-making in pregnant women coming for genetic counselling based on atypical screening of one of the screening tests, or an issue in personal or family history. This is the first study done in in the Czech environment. Among other things, lack of awareness and widespread confusion about screening and invasive tests were discovered, creating the distress that pregnant women here often unnecessarily experience.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(1):163-165 | 10.5507/bp.2013.056
Primary aldosteronism is a relatively common cause of secondary hypertension. Hyperandrogenic conditions tend to have their origin in the adrenal cortex. The authors report a very rare combination of adrenocortical adenoma as a source of overproduction of aldosterone and benign tumor of the ovary, as the source of testosterone production. The patient was completely healed by one laparoscopic procedure.