Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019, 163(1):8-18 | DOI: 10.5507/bp.2018.071

Mesenchymal stem cells as the near future of cardiology medicine - truth or wish?

Michaela Brychtova, Jana-Aletta Thiele, Daniel Lysak, Monika Holubova, Milena Kralickova, Lucie Vistejnova
Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00 Pilsen, Czech Republic

Cardiac damage is one of major cause of worldwide morbidity and mortality. Despite the development in pharmacotherapy, cardiosurgery and interventional cardiology, many patients remain at increased risk of developing adverse cardiac remodeling. An alternative treatment approach is the application of stem cells. Mesenchymal stem cells are among the most promising cell types usable for cardiac regeneration. Their homing to the damaged area, differentiation into cardiomyocytes, paracrine and/or immunomodulatory effect on cardiac tissue was investigated extensively. Despite promising preclinical reports, clinical trials on human patients are not convincing. Meta-analyses of these trials open many questions and show that routine clinical application of mesenchymal stem cells as a cardiac treatment may be not as helpful as expected. This review summarizes contemporary knowledge about mesenchymal stem cells role in cardiac tissue repair and discusses the problems and perspectives of this experimental therapeutical approach.

Keywords: mesenchymal stem cells, cardiomyocytes, cardiology, cardiac regeneration, results translation

Received: July 18, 2018; Accepted: October 28, 2018; Prepublished online: November 15, 2018; Published: February 18, 2019  Show citation

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Brychtova, M., Thiele, J., Lysak, D., Holubova, M., Kralickova, M., & Vistejnova, L. (2019). Mesenchymal stem cells as the near future of cardiology medicine - truth or wish? Biomedical papers, 163(1), 8-18. doi: 10.5507/bp.2018.071
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