Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(3):437-441 | DOI: 10.5507/bp.2014.020

Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion

Martina Vasatova^a, Radek Pudil^b, Tomas Buchler^c, Iva Karesova^a, Vaclav Safka^d, Tomas Fejfar^d, Petr Hulek^d

^a Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic

^b 1^st Department of Internal Medicine - Cardioangiology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague

^c Department of Oncology, 1^st Faculty of Medicine, Charles University in Prague and Thomayer University Hospital, Prague

^d 2^nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague

Background: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion.

Methods: The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient.

Results: Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025).

Conclusion: GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure.

Keywords: glycogen phosphorylase BB, cardiac marker, cirrhosis, biochip, portal hypertension, TIPS

Received: October 22, 2013; Accepted: April 7, 2014; Prepublished online: April 29, 2014; Published: September 30, 2015  Show citation