Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013, 157(4):304-310 | DOI: 10.5507/bp.2013.028

Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients

Deepika Shuklaa, Alka Dinesh Kaleb, Seema Hallikerimathc, Venkatakanthaiah Yerramallad, Vivekanandhan Subbiahd, Shashwat Mishrae
a Department of Oral Pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, Delhi, India
b KLE VK Institute of Dental Sciences and Hospital, Belgaum, Karnataka, India
c Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Belgaum, Karnataka
d Neurobiochemistry, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi
e Department of Neurosurgery, Ram Manohar Lohia Institte of Medical Sciences, Lucknow

Aims: Cancer patient's inherited genotype may influence his or her survival, but evidence for the role of these genetic differences in oral cancer survival has not yet been explored.

Methods: The authors evaluated polymorphisms in the GSTM1 and CYP1A1 genes for associations with overall survival in 100 oral squamous cell carcinoma (OSCC) treated patients and 100 controls who were followed up for survival within 2 years of the date of completion of their treatment. Overall survival was evaluated in Kaplan-Meier survival functions and Cox proportional hazards models.

Results: After adjustment for stage and histology, GSTM1null genotype was associated with shorter survival among OSCC patients, compared with GSTM1 present genotype. There was no association between CYP1A1 C genotype and survival in the overall study population.

Conclusion: The study indicated a potential role for GSTM1 polymorphism in predicting the clinical outcomes of treated oral carcinoma patients.

Keywords: glutathione S transferase, cytochrome P450, polymorphism, oral squamous cell carcinoma, survival

Received: November 14, 2012; Accepted: April 16, 2013; Prepublished online: May 3, 2013; Published: December 12, 2013  Show citation

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Shukla, D., Dinesh Kale, A., Hallikerimath, S., Yerramalla, V., Subbiah, V., & Mishra, S. (2013). Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients. Biomedical papers, 157(4), 304-310. doi: 10.5507/bp.2013.028
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