Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012, 156(3):260-261

Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method

Ivo Flugera, Katerina Maderovaa, Martin Simeka, Roman Hajeka, Jana Zapletalovab, Vladimir Lonskya
a Department of Cardiac Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Department of Biomedicine and Statistics, Faculty of Medicine and Dentistry, Palacky University Olomouc

Aim: To compare assessment of fibrinogen by thromboelastography with the standard von Clauss method.

Methods: Observational prospective study.

Results: Thromboelastography provides direct and complex evaluation of the entire coagulation cascade based upon changes in blood viscosity. It affects both platelets and plasma components. New application of this method measures fibrinogen contribution to coagulation as opposed to fibrinogen antigen levels measured by immunoassay. Paired samples from 117 patients before cardiopulmonary bypass were compared. A moderate correlation was found between fibrinogen and functional fibrinogen with a Spearman correlation coefficient of 0.476.

Conclusion: The functional fibrinogen test is a valid point-of-care method for fibrinogen assay with a moderate correlation to the standard method.

Keywords: fibrinogen, functional fibrinogen, thromboelastography, coagulation, cardiopulmonary bypass

Received: February 3, 2011; Accepted: June 1, 2011; Prepublished online: June 28, 2011; Published: September 1, 2012  Show citation

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Fluger, I., Maderova, K., Simek, M., Hajek, R., Zapletalova, J., & Lonsky, V. (2012). Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method. Biomedical papers, 156(3), 260-261
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