Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021, 165(2):229-232 | DOI: 10.5507/bp.2020.002

Atypical carcinoma detected after regression of a "benign" oral white lesion. A case report

Jan Srubara, Tereza Uhrikovaa, Patricie Delongovab
a Department of Oral and Maxillofacial Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic
b Department of Pathology, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic

Background: Unlike leukoplakia, the smokers' lesion - a type of oral white lesion spontaneously regressing following cessation of smoking - is generally considered a non-serious condition and there is no recommendation for subsequent follow-up of such patients.

Case report: Here, however, we present the case of a patient (female, 56, smoker) in whom we detected a smoker's lesion which regressed completely, without any signs of abnormality or malignity. The only shadow of a doubt that led us to inviting her for another examination was an additional examination using a VELscope® autofluorescence device that revealed autofluorescence suppression on the site of the former lesion. Another examination one month later revealed a patch of epithelium with a normal color but a negligibly different light reflection in the center of the former lesion; VELscope® indicated the questionable area to still be suspect. Following excision using margins indicated by VELscope® (+2-3 mm), histopathology revealed a squamous cell carcinoma. The secondary excision was carcinoma free and even after 5 years, the carcinoma has not recurred.

Conclusion: We would like to point out that apparent spontaneous regressions of oral white lesions following smoking cessation still need attention and close follow-up to make sure that a developing squamous cell carcinoma cannot pass undetected.

Keywords: smokers' lesion, oral white lesion, squamous cell carcinoma, leukoplakia, regression, cessation of smoking

Received: October 18, 2019; Revised: December 1, 2019; Accepted: January 20, 2020; Prepublished online: February 25, 2020; Published: June 10, 2021  Show citation

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Srubar, J., Uhrikova, T., & Delongova, P. (2021). Atypical carcinoma detected after regression of a "benign" oral white lesion. A case report. Biomedical papers, 165(2), 229-232. doi: 10.5507/bp.2020.002
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