Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(3):277-283 | DOI: 10.5507/bp.2019.023
Salivary gland function in thyroid cancer patients with radioiodine administration history
- a Department of Nuclear Medicine, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
- b Academic Department of Internal Medicine, Charles University, Faculty of Medicine in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
- c 4
- th Department of Internal Medicine, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
Aim: Radioiodine (RAI) improves survival in patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC). Although there has been an ongoing debate on RAI-induced salivary gland damage, published data have been inconsistent. Therefore, the purpose of our study was to compare salivary gland function in intermediate and high risk DTC patients after single or repeated RAI treatment with their age- and sex-matched RAI-naive counterparts.
Methods: Uptake and excretion of parotid and submandibular glands were quantitatively evaluated using 99mTc-pertechnetate salivary gland scintigraphy in 23 patients previously treated with RAI. Patients (median 9.25 GBq 131I-NaI; Q1-Q3: 5.55-16.65; range: 5.55-27.5) were divided into subgroups according to previously administered 131I-NaI activity using cut-off values 5.55 GBq and 9.25 GBq. Their salivary gland scintigraphy results were compared with RAI-naive patients using Mann-Whitney test.
Results: Compared to RAI-naive patients, parotid glands pertechnetate uptake was significantly lower in those treated with > 9.25 GBq (P=0.034) and parotid glands excretion fraction was already decreased with RAI activities > 5.55 GBq (P=0.031). In submandibular glands, no statistically significant difference in either function was observed even with RAI activity > 9.25 GBq.
Conclusion: Our data suggest that RAI therapy using activities ≤ 5.55 GBq does not substantially decrease saliva production. Activities > 5.55 GBq may lead to significant decrease in parotid excretion, and activities > 9.25 GBq also diminish parotid uptake. Surprisingly, submandibular glands, providing majority of seromucinous saliva under basal condition, seem to be unaffected even by RAI activities above 9.25 GBq.
Keywords: radioiodine, thyroid cancer, salivary gland dynamic scintigraphy, 99mTc-pertechnetate
Received: March 8, 2019; Revised: May 14, 2019; Accepted: May 20, 2019; Prepublished online: June 17, 2019; Published: September 17, 2020 Show citation
ACS | AIP | APA | ASA | Harvard | Chicago | Chicago Notes | IEEE | ISO690 | MLA | NLM | Turabian | Vancouver |
References
- McCready VR. Radioiodine - the success story of Nuclear Medicine. Eur J Nucl Med Mol Imaging 2017;44(2):179-2.
Go to original source...
Go to PubMed...
- Verburg FA, Stokkel MPM, Düren C, Verkooijen RBT, Mäder U, van Isselt JW, Marlowe RJ, Smit JW, Reiners C, Luster M. No survival difference after successful 131I ablation between patients with initially low-risk and high-risk differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2010;37(2):276-3.
Go to original source...
Go to PubMed...
- Verburg FA, Luster M, Giovanella L, Lassmann M, Chiesa C, Chouin N, Flux G. The "reset button" revisited: why high activity 131I therapy of advanced differentiated thyroid cancer after dosimetry is advantageous for patients Eur J Nucl Med Mol Imaging 2017;44(6):915-7.
Go to original source...
Go to PubMed...
- Lassmann M, Hänscheid H, Chiesa C, Hindorf C, Flux G, Luster M; EANM Dosimetry Committee. EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy. Eur J Nucl Med Mol Imaging 2008;35(7):1405-2.
Go to original source...
Go to PubMed...
- Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, Caillou B, Ricard M, Lumbroso JD, De Vathaire F, Schlumberger M. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006;91(8):2892-9.
Go to original source...
Go to PubMed...
- Mazzaferri EL , Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994;97(5):418-28.
Go to original source...
Go to PubMed...
- Mandel SJ, Mandel L. Radioactive iodine and the salivary glands. Thyroid 2003;13(3):265-71.
Go to original source...
Go to PubMed...
- Lamartina L, Cooper DS. Radioiodine remnant ablation in low-risk differentiated thyroid cancer: the "con" point of view. Endocrine 2015;50(1):67-71.
Go to original source...
Go to PubMed...
- Ain KB. Radioiodine-remnant ablation in low-risk differentiated thyroid cancer: pros. Endocrine 2015;50(1):61-6.
Go to original source...
Go to PubMed...
- Blumhardt R, Wolin EA, Phillips WT, Salman UA, Walker RC, Stack BC Jr, Metter D. Current controversies in the initial post-surgical radioactive iodine therapy for thyroid cancer: a narrative review. Endocr Relat Cancer 2014;21(6):R473-84.
Go to original source...
Go to PubMed...
- Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, et al. The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance. Endocr Rev 2003;24(1):48-77.
Go to original source...
Go to PubMed...
- Mares J. Fyziologie trávení a vstřebávání. In: Trojan S, Langmeier M, editors. Lékařská fyziologie. Praha: Grada Publishing; 2003. p.323-327.
- Walter MA, Turtschi CP, Schindler C, Minnig P, Müller-Brand J, Müller B. The dental safety profile of high-dose radioiodine therapy for thyroid cancer: long-term results of a longitudinal cohort study. J Nucl Med 2007;48(10):1620-5.
Go to original source...
Go to PubMed...
- Alexander C, Bader JB, Schaefer A, Finke C, Kirsch CM. Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma. J Nucl Med 1998;39(9):1551-4.
Go to PubMed...
- Grewal RK, Larson SM, Pentlow CE, Pentlow KS, Gonen M, Qualey R, Natbony L, Tuttle RM. Salivary gland side effects commonly develop several weeks after initial radioactive iodine ablation. J Nucl Med 2009;50(10):1605-10.
Go to original source...
Go to PubMed...
- Hollingsworth B, Senter L, Zhang X, Brock GN, Jarjour W, Nagy R, Brock P, Coombes KR, Kloos RT, Ringel MD, Sipos J, Lattimer I, Carrau R, Jhiang SM. Risk Factors of 131I-Induced Salivary Gland Damage in Thyroid Cancer Patients. J Clin Endocrinol Metab 2016;101(11):4085-3.
Go to original source...
Go to PubMed...
- Jentzen W, Hobbs RF, Stahl A, Knust J, Sgouros G, Bockisch A. Pre-therapeutic (124)I PET(/CT) dosimetry confirms low average absorbed doses per administered (131)I activity to the salivary glands in radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2010;37(5):884-95.
Go to original source...
Go to PubMed...
- Liu B, Huang R, Kuang A, Zhao Z, Zeng Y, Wang J, Tian R. Iodine kinetics and dosimetry in the salivary glands during repeated courses of radioiodine therapy for thyroid cancer. Med Phys Oct;38(10):5412-9.
- European Association of Nuclear Medicine. Internal Dosimetry Task Force Report on: Treatment planning For Molecular Radiotherapy Potential And Prospects. [cited 2019 Feb 18]. Available from: https://www.eanm.org/publications/idtf-report/
- Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph W, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26(1):1-133.
Go to original source...
Go to PubMed...
- Klutmann S, Bohuslavizki KH, Kröger S, Bleckmann C, Brenner W, Mester J, Clausen M. Quantitative salivary gland scintigraphy. J Nucl Med Technol 1999;27(1):20-6.
- Bohuslavizki KH, Brenner W, Lassmann S, Tinnemeyer S, Tönshoff G, Sippel C, Wolf H, Clausen M, Henze E. Quantitative salivary gland scintigraphy in the diagnosis of parenchymal damage after treatment with radioiodine. Nucl Med Commun 1996;17(8):681-6.
Go to original source...
Go to PubMed...
- Almeida JP, Sanabria AE, Lima EN, Kowalski LP. Late side effects of radioactive iodine on salivary gland function in patients with thyroid cancer. Head Neck 2011;33(5):686-90.
Go to original source...
Go to PubMed...
- Solans R, Bosch JA, Galofré P, Porta F, Roselló J, Selva-O'Callagan A, Vilardell M. Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy. J Nucl Med 2001;42(5):738-43.
Go to PubMed...
- Wu JQ, Feng HJ, Ouyang W, Sun YG, Chen P, Wang J, Xian JL, Huang LH. Systematic evaluation of salivary gland damage following I-131 therapy in differentiated thyroid cancer patients by quantitative scintigraphy and clinical follow-up. Nucl Med Commun 2015;36(8):819-26.
Go to original source...
Go to PubMed...
- Maruoka Y, Baba S, Isoda T, Kitamura Y, Abe K, Sasaki M, Honda H. A Functional Scoring System Based on Salivary Gland Scintigraphy for Evaluating Salivary Gland Dysfunction Secondary to (131)I therapy in Patients with Differentiated Thyroid Carcinoma. J Clin Diagn Res 2017;11(8):TC23-8.
Go to original source...
Go to PubMed...
- Hermann GA, Vivino FB, Shnier D, Krumm RP, Mayrin V, Shore JB. Variability of quantitative scintigraphic salivary indices in normal subjects. J Nucl Med1998;39(7):1260-3.
Go to PubMed...
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.