Biomedical papers, 2016 (vol. 160), issue 3

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(3):358-362 | 10.5507/bp.2016.016

High incidence of monozygotic twinning in infertility treatment

Ales Sobek Jr.a,c, Martin Prochazkab, Eva Klaskovac,d, Marek Lubuskya, Radovan Pilkaa
a Department of Obstetrics and Gynecology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Department of Medical Genetics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
c Fertimed Infertility Center, Boleslavova 2, 77200 Olomouc, Czech Republic
d Department of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

Background: Monozygotic twinning is associated with increased perinatal morbidity and mortality. There is evidence that the number of monozygotic twins increases after assisted reproductive techniques.

Methods: We searched PUBMED, MEDLINE, and Scopus from 1987 to 2015 for studies analyzing the incidence and possible etiology of monozygotic twinning in infertility patients and critically reviewed the current state of knowledge.

Results and Conclusions: Monozygotic twinning is a rare in natural conception but occurs around twice the normal rate after assisted reproduction. Factors associated with this phenomenon remain speculative, though there is some evidence that micromanipulation techniques, prolonged culture, and genetics are involved. In view of the possible complications, adequate pre-conception counselling is advocated.

Keywords: monozygotic twins, infertility, incidence, risk factors

Received: December 1, 2015; Accepted: March 15, 2016; Prepublished online: April 1, 2016; Published: September 20, 2016


References

  1. Derom C, Vlietinck R, Derom R, Van den Berghe H, Thiery M. Increased monozygotic twinning rate after ovulation induction. Lancet 1987;1:1236-8. Go to original source... Go to PubMed...
  2. Luke B, Brown MB, Wantman E, Stern JE. Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles. Fertil Steril 2014;101(3):683-9. Go to original source... Go to PubMed...
  3. Stockard CR. Developmental rate and structural expression: an experimental study of twins, double monsters and single deformities, and the interaction among embryonic organs during their origin and development. American Journal of Anatomy 1921;28:115-262. Go to original source...
  4. McLaren A, Molland P, Signer E. Does monozygotic twinning occur in mice? Genetical Research 1995;66:195-202. Go to original source... Go to PubMed...
  5. Hall JG. Twinning. Lancet 2003;362:735-43. Go to original source... Go to PubMed...
  6. Sobek A Jr, Zbořilová B, Procházka M, Šilhánová E, Koutná O, Klásková E, Tkadlec E, Sobek A. High incidence of monozygotic twinning after assisted reproduction is related to genetic information, but not to assisted reproduction technology itself. Fert Ster 2015;3:756-60. Go to original source... Go to PubMed...
  7. Pinborg A, Loft A, Rasmussen S, Andersen N. Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: a controlled Danish national cohort study. Hum Reprod 2004;19:2529-36. Go to original source... Go to PubMed...
  8. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation. Hum Reprod 2001;16:1264-9. Go to original source... Go to PubMed...
  9. Tarlatzis B, Qublan H, Sanopoulou T, Zepiridis L, Brimbizis B, Bontis J. Increase in the monozygotic twinning rate after intracytoplasmic sperm injection and blastocyst stage embryo transfer. Fertil Steril 2002;77:196-8. Go to original source... Go to PubMed...
  10. Zhu JL, Basso 0, Obel C, Christensen K, Olsen J. Infertility, infertility treatment and twinning: the Danish National Birth Cohort Human Reprod 2007;4:1086-90.
  11. Vitthala S, Gelbaya1 TA, Brison DR, Fitzgerald CT, Nardo LG. The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis. Hum Rep Update 2009;15(1):45-55. Go to original source... Go to PubMed...
  12. Sills ES, Moomjy M, Naninovic N, Veeck L, McGee M, Palermo GD, Rosenwaks Z. Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF. Hum Reprod 2000;15:890-5. Go to original source... Go to PubMed...
  13. Kanter JR, Boulet SL, Kawwass JF, Jamieson DJ, Kissin DM. Trends and correlates of monozygotic twinning after single embryo transfer. Obstet Gynecol 2015;1:111-7. Go to original source...
  14. Elizur SE, Levron J, Shrim A, Sivan E, Dor J, Shulman. Monozygotic twinning is not associated with zona pellucida micromanipulation procedures but increases with high-order multiple pregnancies. Fertil Steril 2004;2:500-1. Go to original source... Go to PubMed...
  15. Milki AA, Jun SH, Behr B, Giudice LC, Westphal LM. Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertil Steril 2003;79:504-6. Go to original source... Go to PubMed...
  16. Adler A, Lee H-L, McCulloh DH, Ampeloquio E, Clarke-Williams M, Wertz BH. Blastocyst culture selects for euploid embryos: comparison of blastomere and trophectoderm biopsies. Reprod Biomed Online 2014;28:485-91. Go to original source... Go to PubMed...
  17. Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. The Cochrane Database of Systematic Reviews. 2012, Issue 7. Art. No.: CD002118. doi: 10.1002/14651858.CD002118.pub4 Go to original source... Go to PubMed...
  18. Rijnders PM, van Os HC, Jansen CAM. Increased incidence of monozygotic twinning following the transfer of blastocysts in human IVF/ICSI. Fertil Steril 1998;70(1):15-6.
  19. Peramo B, Ricciarelli E, Cuadros-Fernandez JM, Huguet E, Hernandez ER. Blastocyst transfer and monozygotic twinning. Fertil Steril 1999;72:1116-7. Go to original source... Go to PubMed...
  20. da Costa AA, Abdelmassih S, de Oliveira FG, Abdelmassih V, Abdelmassih R, Nagy ZP. Monozygotic twins and transfer at the blastocyst stage after ICSI. Hum Reprod 2001;16:333-6. Go to original source... Go to PubMed...
  21. Behr B, Fisch JD, Racowsky C, Miller K, Poole R, Milki AA. Blastocyst-ET and monozygotic twinning. J Assist Reprod Genet 2000;17:349-51. Go to original source... Go to PubMed...
  22. Wright V, Schieve LA, Vahratian A, Reynolds MA. Monozygotic twinning associated with day 5 embryo transfer in pregnancies conceived after IVF. Hum Reprod 2004;19:18316. Go to original source... Go to PubMed...
  23. Franasiak JM , Dondik Y, Molinaro TA, Hong KH, Forman EJ, Werner MD, Upham KM, Scott RT Jr. Blastocyst transfer is not associated with increased rates of monozygotic twins when controlling for embryo cohort quality. Fertil Steril 2015;1:95-100. Go to original source... Go to PubMed...
  24. Alikani M, Cekleniak NA, Walters E, Cohen J. Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases. Hum Reprod 2003;18:1937-43. Go to original source... Go to PubMed...
  25. Hsu YC, Gonda MA. Monozygotic twin formation in mouse embryos in vitro. Science 1980;209:605-6. Go to original source... Go to PubMed...
  26. Steinman G. Mechanisms of twinning VI. Genetics and the etiology of monozygotic twinning in in vitro fertilization. Journal of Reproductive Medicine 2003;48:583-90. Go to PubMed...
  27. Knopman J, Krey LC, Lee J, Fino E, Novetsky AP, Noyes N. Monozygotic twinning: an eight-year experience at a large IVF center. Fertil Steril 2010;94:502-10. Go to original source... Go to PubMed...
  28. Harvey M, Huntley R, Smith D. Familial monozygotic twinning. The Journal of Pediatrics 1977;90:246-9. Go to original source... Go to PubMed...
  29. Hamamy HA, Ajlouni HK, Ajlouni KM. Familial monozygotic twinning: report of an extended multi-generation family. Twin Research 2004;7:219-22. Go to original source... Go to PubMed...
  30. Shapiro LR, Zemek L, Shulman MJ. Genetic aethiology for monozygotic twinning. Birth defects. Orig Art Series 1978;14:219-25.
  31. Bulmer MG. The Biology of Twinning in Man. Oxford, UK: Oxford University Press, 1970.
  32. Cohen J, Feldberg D. Effects of the size and number of zona pellucida openings on hatching and trophoblast outgrowth in the mouse embryo. Mol Report Dev 1991;30:70-8. Go to original source... Go to PubMed...
  33. Verpoest W, Landuyt LV, Desmyttere S, Cremers A, Devroey P, Liebaers I. The incidence of monozygotic twinning following PGD is not increased. Hum Rep 2009;24(11):2945-50. Go to original source... Go to PubMed...
  34. Toledo M. Is there increased monozygotic twinning after assisted reproductive technology? Aust N Z J Obstet Gynaecol 2005;45:360-4. Go to original source... Go to PubMed...
  35. Kim JA, Jeong Yeon Cho, Kyeong Chun. Complications Arising in Twin Pregnancy: Findings of Prenatal Ultrasonography. Korean J Radiol 2003;4:54-60. Go to original source... Go to PubMed...
  36. De Villiers SF, Zhao DP, Cohen D, van Zwet EW, Duan T, Oepkes D, Lopriore E. Correlation between veno-venous anastomoses, TTTS and perinatal mortality in monochorionic twin pregnancies. 2015;5:603-6. Go to PubMed...