Biomedical papers, 2014 (vol. 158), issue 1

From editor desk

Jitka Ulrichova, Vilim Simanek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):

Review articles

Effects of β-glucan on some environmental toxins: An overview

Vaclav Vetvicka

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):001-004 | 10.5507/bp.2013.090

The well-know immune stimulator β-glucan, can have a less-known function - it can protect against the adverse effects of various environmental toxins including mercury, depleted uranium, mycotoxins and aflatoxins. This review represents a state-of-the-art review of the antitoxic effects of β-glucan.

The effect of nano-scale topography on osteogenic differentiation of mesenchymal stem cells

Faezeh Faghihi, Mohamadreza Baghaban Eslaminejad

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):005-016 | 10.5507/bp.2013.013

This article evaluates the effect of topography, as one of the remarkable characteristics of substrate, on induction and promotion of the signaling pathways involved in osteogenic differentiation of MSCs.

Autoimmune pancreatitis

Petr Dite, Hana Nechutova, Magdalena Uvirova, Jana Dvorackova, Bohuslav Kianicka, Arnost Martinek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):017-022 | 10.5507/bp.2013.094

This review summarizes recent knowledge about autoimmune pancreatitis as a unique clinical entity within putative IgG4 diseases.

Adrenal disease: a clinical update and overview of imaging. A review

Filip Ctvrtlik, Pavel Koranda, Tomas Tichy

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):023-034 | 10.5507/bp.2014.010

This article provides an overview of the most frequent clinically significant adrenal diseases and to describe the latest trends in their diagnostics, particularly by means of imaging techniques.

Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review

Peter Stanko, Lydie Izakovicova Holla

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):035-038 | 10.5507/bp.2014.005

Diabetes mellitus increases the risk for and severity of marginal periodontitis and conversely periodontal treatment improves glycemic control in patients with type 2 diabetes.

Original contributions

Valproate activates ERK signaling pathway in primary human hepatocytes

Michal Bitman, Radim Vrzal, Zdenek Dvorak, Petr Pavek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):039-043 | 10.5507/bp.2012.038

Valproic acid (VPA) is a widely-used anticonvulsant, which also inhibits histone deacetylases (HDACs), enzymes that affect the expression of numerous genes. VPA activates the extracellular signal-related kinase (ERK, p42/p44) pathway (Ras-Raf-MEK-ERK) belonging to the mitogen-activated protein kinase (MAPKs) pathways in primary human hepatocytes.

Investigation of tumour supressor protein p53 in renal cell carcinoma patients

Ingrid Hodorova, Peter Solar, Jozef Mihalik, Janka Vecanova, Marian Adamkov, Silvia Rybarova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):044-049 | 10.5507/bp.2012.035

Our data demonstrate that p53 might play an important role in this tumour development or progression and it might be used as a new predictor and therapeutic target for renal cell carcinoma.

Histologic evaluation of AlphaCor keratoprosthesis explanted following various complications

Nada Jiraskova, Liliana Werner, Nick Mamalis, Pavel Rozsival

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):050-055 | 10.5507/bp.2012.040

Histologic findings in two AlphaCor explanted following different complications confirm adequate biointegration of the artificial corneas. Epithelial in growth and scattered chronic mononuclear inflammatory cells were observed in the area of partial extrusion

Array-based karyotyping in chronic lymphocytic leukemia (CLL) detects new unbalanced abnormalities that escape conventional cytogenetics and CLL FISH panel

Helena Urbankova, Tomas Papajik, Radek Plachy, Milena Holzerova, Jana Balcarkova, Martina Divoka, Vit Prochazka, Zuzana Pikalova, Karel Indrak, Marie Jarosova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):056-064 | 10.5507/bp.2012.031

This article focuses on the contribution of the arrayCGH technique to detection of copy number aberrations in chronic lymphocytic leukemia

Vancomycin pharmacokinetics during high-volume continuous venovenous hemofiltration in critically ill septic patients

Nadezda Petejova, Arnost Martinek, Jana Zahalkova, Jana Duricova, Hana Brozmannova, Karel Urbanek, Milan Grundmann, Jiri Plasek, Ivana Kacirova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):065-072 | 10.5507/bp.2012.092

Acute kidney injury (AKI) is a common complication in patients with critical conditions like sepsis. Dosing of antibacterial agents in critically ill septic patients is complicated by altered pharmacokinetics due to both AKI and critical illness. Changes in pharmacokinetics, suitable therapeutic drug monitoring and possible dosing regimens for administrating vancomycin to septic patients with AKI on high-volume continuous venovenous hemofiltration at a filtration rate 45 mL/kg b.w./h are presented.

Effect of progesterone-carbachol derivative on perfusion pressure and coronary resistance in isolated rat heart: via activation of the M2 muscarinic receptor

Lauro Figueroa-Valverde, Francisco Diaz-Cedillo, Elodia Garcia-Cervera, Eduardo Pool Gomez, Maria Lopez-Ramos

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):073-079 | 10.5507/bp.2012.010

The mechanism of the activity exerted by a progesterone-carbachol derivative is described.

Per3 VNTR polymorphism and chronic heart failure

Jolana Lipkova, Julie Anna Bienertova-Vasku, Lenka Spinarova, Petr Bienert, Marian Hlavna, Monika Pavkova Goldbergova, Jiri Parenica, Jindrich Spinar, Anna Vasku

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):080-083 | 10.5507/bp.2012.069

This study focuses on the effect of genetic variability in circadian genes (Period3) as a potential risk factor for chronic heart failure or factor modulating severity of heart failure.

Arrhythmias and ECG changes in life threatening hyperkalemia in older patients treated by potassium sparing drugs

Marie Berkova, Zdenek Berka, Eva Topinkova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):084-091 | 10.5507/bp.2012.087

The combination of decrease in functional capacities, polymorbidity and polypharmacy in old people can cause life threatening electrolyte imbalance with fatal rhythm disturbance and terminal heart arrest. The article points out the often overlooked risk of hyperkalemia in elderly people treated by renin-angiotensin-aldosterone system influencing pharmacotherapy and proposes a solution to critical situations.

The variable clinical course of peripartum cardiomyopathy

Jan Krejci, Petr Hude, Lenka Spinarova, Vita Zampachova, Alzbeta Sirotkova, Tomas Freiberger, Eva Nemcova, Jiri Vitovec

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):092-097 | 10.5507/bp.2012.080

The article deals with peripartum cardiomyopathy, a relatively rare disease, which is very likely in our region underdiagnosed. Increased awareness of the disease should contribute to its detection. The authors describe their own experience with the diverse clinical course of the disease. When properly diagnosed and treated it has a very good prognosis, and vice versa unrecognized or improperly treated can have fatal consequences.

Exercise training combined with electromyostimulation in the rehabilitation of patients with chronic heart failure: A randomized trial

Vladimir Soska, Petr Dobsak, Michal Pohanka, Lenka Spinarova, Jiri Vitovec, Jan Krejci, Petr Hude, Pavel Homolka, Marie Novakova, Jean-Christophe Eicher, Jean-Eric Wolf, Ladislav Dusek, Jarmila Siegelova

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):098-106 | 10.5507/bp.2012.096

Training protocol based on neuromuscular electrical stimulation of leg muscles combined with standard type of exercise bicycle training, demonstrates significant beneficial effects on physical performance and quality of life in patients with moderate grade of chronic heart failure.

Quantification of pleural effusion on CT by simple measurement

Martin Hazlinger, Filip Ctvrtlik, Katerina Langova, Miroslav Herman

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):107-111 | 10.5507/bp.2012.042

A simple method of pleural effusion volume quantification based on a single planar measurement on CT scan is devised. The described method is widely applicable in adult patients with free pleural effusion, easy to perform and appropriately accurate.

Comparison of a low-glycemic index vs standard diabetic diet

Jakub Visek, Silvie Lacigova, Daniela Cechurova, Zdenek Rusavy

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):112-116 | 10.5507/bp.2012.103

This article compares the efficiency of a commonly used diabetic diet and diet with a low glycemic index in patients with type 2 diabetes mellitus.

Severity of periodontal disease in adult patients with diabetes mellitus in relation to the type of diabetes

Alma Pranckeviciene, Jolanta Siudikiene, Rytas Ostrauskas, Vita Machiulskiene

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):117-123 | 10.5507/bp.2013.098

This study evaluates associations between diabetes mellitus and stages of periodontal disease in adult patients.

Intrathecal synthesis in particular types of multiple sclerosis

Vladimira Sladkova, Jan Mares, Petr Hlustik, Jana Langova, Petr Kanovsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):124-126 | 10.5507/bp.2012.054

The article discusses the differences in intrathecal synthesis IgG (IgG index) and number of oligoclonal IgG bands in various forms of multiple sclerosis.

A comparison of complication rate between anterior and lateral approaches to the lumbar spine

Lumir Hrabalek, Milan Adamus, Adolf Gryga, Tomas Wanek, Peter Tucek

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):127-132 | 10.5507/bp.2012.079

This article compares the advantages and disadvantages of both anterior approaches to the lumbar spine, traditional ALIF and new XLIF procedures.

Central facial paresis and its impact on mimicry, psyche and quality of life in patients after stroke

Petr Konecny, Milan Elfmark, Stanislav Horak, Dalibor Pastucha, Alois Krobot, Karel Urbanek, Petr Kanovsky

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):133-137 | 10.5507/bp.2013.014

Loss of facial expressions is a serious problem in patients after stoke. Targeted orofacial rehabilitation significantly reduces these problems.

Progression of macular atrophy after PDT combined with the COX-2 inhibitor Nabumetone in the treatment of neovascular ARMD

Martin Sin, Oldrich Chrapek, Marta Karhanova, Zuzana Pracharova, Katerina Langova, Jiri Rehak

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):138-143 | 10.5507/bp.2012.066

A unique clinical study investigating the effects of preferential COX-2 in the treatment of exudative age-related macular degeneration. The results suggest a possible neuroprotective effect of COX-2

Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma

Jan Lestak, Jaroslav Tintera, Zuzana Svata, Lukas Ettler, Pavel Rozsival

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):144-153 | 10.5507/bp.2013.038

High tension and normal tension glaucoma are regarded worldwide as "one disease". Our study shows the differences between the two diagnostic groups.

Case reports

A complex oncosurgical approach to increasing the resectability of colorectal cancer metastases - a case report

Vladislav Treska, Jarmil Safranek, Daniel Lysak, Hynek Mirka, Tomas Skalicky, Frantisek Slauf, Ondrej Hes

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):154-157 | 10.5507/bp.2012.005

Hematopoietic stem cells in combination with portal vein embolization provides new insight into the solution of primary unresectable colorectal liver metastases. The authors present a case report describing successful use of a novel method.

Merkel cell carcinoma. Case report

Richard Pink, Martin Molitor, Jiri Ehrmann, Peter Tvrdy, Petr Michl, Jindrich Pazdera

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):158-160 | 10.5507/bp.2012.034

Merkel cell carcinoma (MCC) is a rare aggressive skin tumour affecting mainly older and immune- suppressed individuals. This case report describes the first experience with Merkel cell carcinoma in an elderly woman on chemo therapy for lymphoma: It covers the diagnosis, treatment and outcome.