Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013, 157(4):277-279 | DOI: 10.5507/bp.2013.073

Multi-analytical evaluation of serum levels of cytokines and adhesion molecules in patients treated for acute myeloid leukemia using biochip array technology

Jan M. Horaceka,b, Martina Vasatovac, Tomas Kupsaa,b, Ladislav Jebavya,b, Pavel Zakb
a Department of Internal Medicine, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
b 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove, Hradec Kralove
c Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Hradec Kralove

Aims: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients treated for acute myeloid leukemia (AML) using biochip array technology. This approach allows multi-analytical determination from a single sample.

Methods: A total of 15 AML patients were studied. Blood samples were taken at the diagnosis (active leukemia) and at circa 6 months after completion of last chemotherapy (durable complete remission in all patients).

Results: Comparing cytokine and adhesion molecule levels in active leukemia and in durable complete remission, we found significant increase (P

Keywords: cytokines, adhesion molecules, biochip array, acute myeloid leukemia

Received: March 26, 2013; Accepted: September 17, 2013; Prepublished online: September 27, 2013; Published: December 12, 2013  Show citation

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Horacek, J.M., Vasatova, M., Kupsa, T., Jebavy, L., & Zak, P. (2013). Multi-analytical evaluation of serum levels of cytokines and adhesion molecules in patients treated for acute myeloid leukemia using biochip array technology. Biomedical papers, 157(4), 277-279. doi: 10.5507/bp.2013.073
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