Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013, 157(4):340-345 | DOI: 10.5507/bp.2013.061

Hypoxia-inducible factor-1α polymorphisms link to coronary artery collateral development and clinical presentation of coronary artery disease

Qian Liu, Yun Liang, Ping Zou, Wei-xin Ni, Yu-guang Li, Song-ming Chen
Department of Cardiology, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China

Aims: This study aimed to investigate the association of Hypoxia-inducible factor-1α (HIF-1α) C1772T and G1790A single nucleotide polymorphisms (SNPs) with: incidence, clinical type, severity of coronary atherosclerosis and coronary collaterals of coronary artery disease (CAD).

Methods: The clinical data and genomic DNA were gathered in 958 subjects, including 560 controls and 398 patients with CAD. CAD was confirmed with coronary angiography (CAG). The genotypes for two SNPs were determined by high resolution melting after PCR amplification.

Results: Neither the HIF-1α C1772T nor the G1790A genotype was significantly associated with CAD and, no gene-gene or gene-environmental interactions were identified. However, both HIF-1α C1772T and G1790A (P

Keywords: coronary artery disease, hypoxia-inducible factor, single nucleotide polymorphism, collaterals

Received: May 6, 2013; Accepted: August 16, 2013; Prepublished online: October 2, 2013; Published: December 12, 2013  Show citation

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Liu, Q., Liang, Y., Zou, P., Ni, W., Li, Y., & Chen, S. (2013). Hypoxia-inducible factor-1α polymorphisms link to coronary artery collateral development and clinical presentation of coronary artery disease. Biomedical papers, 157(4), 340-345. doi: 10.5507/bp.2013.061
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