Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012, 156(1):1-6 | DOI: 10.5507/bp.2012.003

BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Katerina Vrzalikovaa,b, Ciaran Bernard John Woodmana, Paul Gerard Murraya,b
a School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
b Department of Clinical and Molecular Pathology and Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

Aims: The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas.

Methods and results: This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.

Conclusions: BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

Keywords: BLIMP1, Epstein-Barr virus, DLBCL, review

Received: August 29, 2011; Accepted: January 3, 2012; Prepublished online: January 31, 2012; Published: March 1, 2012  Show citation

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Vrzalikova, K., Woodman, C.B.J., & Murray, P.G. (2012). BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas. Biomedical papers, 156(1), 1-6. doi: 10.5507/bp.2012.003
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