Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(3):429-436 | DOI: 10.5507/bp.2014.014

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Klaudia Vyskocilova^a, Lenka Spinarova^a, Jindrich Spinar^b, Tereza Mikusova^a, Jiri Vitovec^a, Josef Malek^c, Filip Malek^d, Ales Linhart^e, Marian Fedorco^f, Petr Widimsky^g, Cestmir Cihalik^h, Jiri Parenica^b, Simona Littnerovaⁱ, Jiri Jarkovskyⁱ

^a 1^st Department of Internal Medicine - Cardioangiology, St. Anne's University Hospital in Brno, International Clinical Research Center and Faculty of Medicine, Masaryk University, Brno, Czech Republic

^b 1^st Department of Internal Medicine - Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno

^c Internal Department, Hospital Havlickuv Brod, Havlickuv Brod

^d Department of Cardiology, Na Homolce Hospital, Prague

^e 2^nd Department of Internal Medicine, General University Hospital and 1^st Faculty of Medicine, Charles University in Prague

^f 1^st Department of Internal Medicine - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc

^g Cardiocenter, University Hospital Kralovske Vinohrady and 3^rd Faculty of Medicine, Charles University in Prague

^h Department of Internal Medicine, T. Bata Regional Hospital, Zlin

ⁱ Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Sciences, Masaryk University, Brno

Aims: Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF).

Methods: The AHEAD (Acute Heart Failure Database) registry is a database conducted in 9 university hospitals and 5 regional health care facilities in the Czech Republic. From December 2004 to October 2012, the data of 8818 patients were included. The inclusion criteria for the database followed the European guidelines for AHF. Serum activities of all LFTs and total bilirubin were available in 1473 patients at the baseline.

Results: In patients with AHF, abnormal LFTs were seen in 76% patients (total bilirubin in 34%, γ-glutamyltransferase in 44%, alkaline phosphatase in 20%, aspartate aminotransferase in 42%, alanine aminotransferase in 35%). Patients with cardiogenic shock were more likely to have LFTs abnormalities compared to mild AHF and pulmonary oedema. LFTs abnormalities were strongly associated with AHF severity (left ventricular ejection fraction and NYHA functional class) and clinical manifestation. While hepatocellular LFTs pattern predominated in left sided forward AHF, cholestatic profile occurred mainly in bilateral and right sided AHF. Additionally, patients with moderate to severe tricuspid regurgitation had significantly higher prevalence of abnormalities in cholestatic LFTs.

Conclusions: Defining the LFTs profile typical for AHF plays an important role in management of AHF patients, since it may avoid redundant hepatic investigations and diagnostic misinterpretations.

Keywords: heart failure, liver function tests, bilirubin, congestive hepatopathy, ischemic hepatitis

Received: September 11, 2013; Accepted: March 4, 2014; Prepublished online: March 13, 2014; Published: September 30, 2015  Show citation