Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):284-287 | DOI: 10.5507/bp.2024.023

Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overview

David Solil1, Petr Dite1, 4, Michal Senkyrik1, Martina Bojkova2, Bohuslav Kianicka3
1 Department of Gastroenterology and Internal Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic
2 Department of Internal Medicine, University Hospital Ostrava, Ostrava, Czech Republic
3 2nd Department of Internal Medicine, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic
4 Department of Clinic Subjects, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic

This is an overview of relation between acute and chronic pancreatitis and between acute pancreatitis and pancreatic cancer. Acute pancreatitis and recurrent acute pancreatitis are an etiological factor of chronic pancreatitis. Population-based studies have calculated the risk of acute recurrent pancreatitis after the first attack of acute pancreatitis to be 20% and development of chronic pancreatitis after first attack of acute pancreatitis is 10%. An important risk factor is tobacco smoking. Acute and chronic pancreatitis are risk factors for pancreatic cancer. The risk of acute pancreatitis is related to the number of recurrences of acute pancreatitis, but not the etiology of acute pancreatitis. Acute pancreatitis, as well as chronic pancreatitis, are risk factors for pancreatic cancer. After an attack of acute pancreatitis or recurrent acute pancreatitis a patient should be regarded as a high risk.

Keywords: acute pancreatitis, chronic pancreatitis, pancreatic cancer, alcohol, etiology, pancreatic cancer localisation

Received: March 14, 2024; Revised: June 21, 2024; Accepted: June 28, 2024; Prepublished online: September 10, 2024; Published: November 22, 2024  Show citation

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Solil, D., Dite, P., Senkyrik, M., Bojkova, M., & Kianicka, B. (2024). Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overview. Biomedical papers, 168(4), 284-287. doi: 10.5507/bp.2024.023
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    References

    1. Phillip V, Huber W, Hagemes F, Lorenz S, Matheis U, Preinfalk S, Schuster T, Lippl F, Saugel B, Schmid RM. Incidence of acute pancreatitis does not increase during Octoberfest, but is higher than previously described in Germany. Clin Gastroenterol Hepatol 2011;9(11):995-1000. doi: 10.1016/j.cgh.2011.06.016 Go to original source... Go to PubMed...
    2. Beyer G, Hoffmeister A, Lorenz P, Lynene P, Lerch MM, Mayerle J. Akute und chronische Pankreatitis. In. Beyer G., Hoffmeister A., Lorenz P. et al: Clinical practice guidelines: Acute and chronic pancreatitis. Dtch Arztebl Int 2022;119(29-30):495-501. doi: 10.3238/arztebl.m2022.0223 Go to original source...
    3. Sah RP, Dawra RK, Saluja AK. New insights into the pathogenesis of pancreatitis. Curr Opin Gastroenterol 2013;29(5):523-30. doi: 10.1097/MOG.0b013e328363e399 Go to original source... Go to PubMed...
    4. Whitcomb DC, Frulloni L, Garg P, Greer JB, Schneider A, Yadav D, Shimosegawa T. Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition. Pancreatology 2016;16(2):218-24. doi: 10.1016/j.pan.2016.02.001 Go to original source... Go to PubMed...
    5. Sankaran SJ, Xiao AY, Wu LM, Windsor JA, Forsmark ChE, Petrov MS. Frequency and progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology 2015;149(6):1490-500. doi: 10.1053/j.gastro.2015.07.066 Go to original source... Go to PubMed...
    6. Bertilsson S, Sward P, Kalaitzakis E. Factors that affect disease progression after first attack of acute pancreatitis. Clin Gastroent Hepatol 2015;13(9):1662-69. doi: 10.1016/j.cgh.2015.04.012 Go to original source... Go to PubMed...
    7. Agarwal S, Sharma S, Gunjan D, Singh N, Kaushal K, Poudel S, Anand A, Gopi S, Mohta S, Sonika U, Saray A. Natural course of chronic pancreatitis and predictors of its progression. Pancreatology 2020;20(3):347-55. doi: 10.1016/j.pan.2020.02.004 Go to original source... Go to PubMed...
    8. Bojkova M, Dite P, Kunovsky L, Blaho M, Kianicka B, Novotny I, Uvirova M, Dvorackova J, Dolina J, Precechtelova M, maskova H, Prochazka V, Janecek P, Motyka O, Martinek A. The role of metabolic syndrome in the induction of chronic pancreatitis after a first attack of acute pancreatitis-multisite study. Vnitr Lek 2020;66(8):12-6. (in Czech) Go to original source...
    9. Gandhi S, de la Fuente I, Murad MH, Majumder S. Chronic pancreatitis is a risk factor for pancreatic cancer, and incidence increases with duration of disease: A systematic review and meta-analysis. Clin Transl Gastroenterol 2022;28;13(3):e00463. doi: 10.14309/ctg.0000000000000463 Go to original source... Go to PubMed...
    10. Kirkegard J, Cronin-Fenton D, Heide-Jorgensen U, Mortensen FV. Acute pancreatitis and pancreatic cancer risk: a nationwide matched-cohort study in Denmark. Gastroenterology 2018;154(6):1729-36. doi: 10.1053/j.gastro.2018.02.011 Go to original source... Go to PubMed...
    11. Sadr-Azodi, Oskarsson V, Discacciati A, Videhult P, Askling J, Ekbom A. Pancreatic cancer following acute pancreatitis: a population-based matched cohort study. Am J Gastroenterol 2018;113(11):1711-19. doi: 10.1038/s41395-018-0255-9 Go to original source... Go to PubMed...
    12. Munigala S, Almaskeen S, Subramaniam DS, BAndi S, Bowe B, Xian H, Sheth SG, Burroughs TE, Agarwal B. Acute pancreatitis recurrences augment long-term pancreatic cancer risk. Am J Gastroenterol 2023;118(4):727-37. doi: 10.14309/ajg.0000000000002081 Go to original source... Go to PubMed...
    13. Rijkers AP, Bakker OJ, Ahmed-Ali U, Hagenaars JCJP. Van Santvoort HC, Besselink MG, Bollen TL, van Eijck CH, Dutch Pancreatitits Study Group. Risk of pancreatic cancer after a primary episode of acute pancreatitis. Pancreas 2017;46(8):1018-22. doi: 10.1097/MPA.0000000000000879 Go to original source... Go to PubMed...
    14. Liu J, Wang Y, Yu Y. Meta-analysis reveals an association between acute pancreatitis and risk of pancreatic cancer. World J Clin Cases 2020;8(19):4416-30. doi: 10.12998/wjcc.v8.i19.4416 Go to original source... Go to PubMed...
    15. Park BK, Seo JH, Chung JB, Choi JK. Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects. Br J Cancer 2022;127(3):549-57. doi: 10.1038/s41416-022-01807-5 Go to original source... Go to PubMed...
    16. Lowenfels AB, Maissoneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, Dimagno EP, Andrén-Sandberg A, Domellof L. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993;328(20):1433-37. doi: 10.1056/NEJM199305203282001 Go to original source... Go to PubMed...
    17. Kudo Y, Kamisawa T, Anjiki H, Takuma K, Egawa N. Incidence of and risk factors for developing of pancreatic cancers in patients with chronic pancreatitis. Hepatogastroenterology 2011;58(106):609-11.
    18. Lew D, Kamal F, Phan K., Randhawa K, Cornwell S, Bangolo AI, Weissman S, Pandol SJ. Epidemiologic risk factors for patients admitted with chronic pancreatitis and pancreatic ductal adenocarcinoma in the United States. World J Clin Oncol 2022;13(11):907-17. doi: 10.5306/wjco.v13.i11.907 Go to original source... Go to PubMed...
    19. Singh RR, Klein AP, Sharma NR, O´Reilly EM. Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study. Cancer Med 2023;12(3):2505-13. doi: 10.1002/cam4.5094 Go to original source... Go to PubMed...
    20. Luo J, Iwasaki M, Inoue M, Sasazuki S, Otani T, Ye W, Tsugane S, JPHC Study Group. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: A large-scale population-based cohort study in Japan-the JPHC study. Cancer Causes Control 2007;18(6):603-12. doi: 10.1007/s10552-007-9002-z Go to original source... Go to PubMed...
    21. Gheorghe G, Ionescu VA, Moldovan H, Diaconu CC. Clinical and biological data in patients with Pancreatic cancer vs. chronic pancreatitis - A single center comparative analysis. Diagnostics (Basel) 2023;13(3):369. doi: 10.3390/diagnostics13030369 Go to original source... Go to PubMed...
    22. Ma DM, Dong XW, Han X, Ling Z, Lu GT, Sun YY, Yin XD. Pancreatitis and pancreatic cancer risk. Technol Cancer Res Treat 2023;22:15330338231164875. doi: 10.1177/15330338231164875 Go to original source... Go to PubMed...
    23. Topaloglu U, Palchuk MB. Using a federated network of real-world data to optimize clinical trials operations. JCO Clin Cancer Inform 2018;2:1-10. doi: 10.1200/CCI.17.00067 Go to original source... Go to PubMed...
    24. Pereira SP, Oldfield L, Ney A, Hart PA, Keane MG, Pandol SJ, Li D, Greenhalf W, Jeon ChY, Koay EJ, Almario ChV, Halloran Ch, Lennon AM, Costello E. Early detection of pancreatic cancer. Lancet Gastroenterol Hepatol 2020;5(7):698-710. doi: 10.1016/S2468-1253(19)30416-9 Go to original source... Go to PubMed...

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