Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):139-144 | DOI: 10.5507/bp.2021.062

Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx

Richard Pink1, Jaroslav Michalek2, David Kral1, Michal Mozola1, Pavel Benes1, Saskova Lenka1, Zdenek Dvorak1, 3
1 Department of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
2 Department of Clinical and Molecular Pathology, University Hospital Olomouc, Czech Republic
3 Department of Plastic and Aesthetic Surgery, St. Anne's Faculty Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic

Aims: The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors.

Methods: The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker.

Results: The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group.

Conclusion: Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.

Keywords: oral squamous cell carcinoma of head and neck, neoplasm invasiveness, head and neck neoplasms, maxillofacial surgery, tumor grading, neoplasm staging, histocytochemistry

Received: September 7, 2021; Revised: October 25, 2021; Accepted: October 26, 2021; Prepublished online: November 15, 2021; Published: June 12, 2023  Show citation

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Pink, R., Michalek, J., Kral, D., Mozola, M., Benes, P., Lenka, S., & Dvorak, Z. (2023). Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx. Biomedical papers, 167(2), 139-144. doi: 10.5507/bp.2021.062
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