Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023, 167(2):109-115 | DOI: 10.5507/bp.2023.020

Postdischarge nausea and vomiting (PDNV) in children: A review and observational study

Michal Frelich1, 2, Vojtech Vodicka1, Ondrej Jor1, 2, Filip Bursa1, 2, Martin Formanek3, Peter Sklienka1, 2, Vaclav Prochazka4
1 Department of Anesthesiology and Intensive Care Medicine, University Hospital of Ostrava, Czech Republic
2 Department of Intensive Medicine, Emergency Medicine and Forensic Studies, Faculty of Medicine, University of Ostrava, Czech Republic
3 Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Ostrava, Czech Republic
4 Radiodiagnostic Institute, University Hospital of Ostrava, Czech Republic

Postdischarge nausea and vomiting (PDNV) cause substantial pediatric morbidity with potentially serious postoperative complications. However, few studies have addressed PDNV prevention and treatment in pediatric patients. Here we searched the literature and processed it in a narrative review describing PDNV incidence, risk factors, and management in pediatric patients.. A successful strategy for reducing PDNV considers both the pharmacokinetics of the antiemetic agents and the principle of multimodal prophylaxis, utilizing agents of different pharmacologic classes. Since many highly effective antiemetic agents have relatively short half-lives, a different approach must be used to prevent PDNV. A combination of oral and intravenous medications with longer half-lives, such as palonosetron or aprepitant, can be used. In addition, we designed a prospective observational study with the primary objective of determining PDNV incidence. In our study group of 205 children, the overall PDNV incidence was 14.6% (30 of 205), including 21 children suffering from nausea and 9 suffering from vomiting.

Keywords: postoperative nausea, postoperative vomiting, postdischarge nausea, postdischarge vomiting, antiemetics, setrons

Received: April 3, 2023; Revised: May 2, 2023; Accepted: May 5, 2023; Prepublished online: May 18, 2023; Published: June 12, 2023  Show citation

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Frelich, M., Vodicka, V., Jor, O., Bursa, F., Formanek, M., Sklienka, P., & Prochazka, V. (2023). Postdischarge nausea and vomiting (PDNV) in children: A review and observational study. Biomedical papers, 167(2), 109-115. doi: 10.5507/bp.2023.020
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