Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022, 166(2):136-139 | DOI: 10.5507/bp.2021.070

The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge

Jozef Muria, Jaroslava Chylikovab, Jozef Skardac, Maria Miklosovaa, Vojtech Kamaradb
a Department of Anatomy, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
b Department of Histology and Embryology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
c Department of Pathology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic and Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic

Tumor-associated macrophages are an important part of the tumor microenvironment. The presence of certain populations of macrophages within tumor tissue may be associated with either better or worse disease prognosis. The study of these cells is currently receiving a great deal of attention, with the most important topics of investigation raised being: the typification of subpopulations of tumor-associated macrophages; identification of the prognostic significance of population density and distribution of macrophages in the tumor microenvironment; ways to influence macrophage activity, migration and differentiation within the tumor. The answers to these questions can improve the efficiency of immunoterapy for malignancies. The presented article briefly reviews recent findings on tumor-associated macrophages in solid malignancies.

Keywords: tumor microenvironment (TME), tumor-associated macrophages (TAMs), resident tissue macrophages (NTAMs), classically activated macrophages (M1), alternatively activated macrophages (M2)

Received: September 16, 2021; Revised: September 16, 2021; Accepted: December 1, 2021; Prepublished online: December 17, 2021; Published: May 13, 2022  Show citation

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Muri, J., Chylikova, J., Skarda, J., Miklosova, M., & Kamarad, V. (2022). The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge. Biomedical papers, 166(2), 136-139. doi: 10.5507/bp.2021.070
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