Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021, 165(1):13-18 | DOI: 10.5507/bp.2020.047

Heterotopic acinic cell carcinoma and its clinical implications

Ivo Stareka, Richard Salzmana, Alena Skalovab
a Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Department of Pathology, Faculty of Medicine in Plzen, Charles University Prague, Czech Republic

This is a review of the clinical and histopathological published data on very rare heterotopic acinic cell carcinomas (AcCCs) with suggested optimal management. Extrasalivary AcCCs originate primarily in parotid lymph nodes. They present at low clinical stage, show mostly low-grade histopathology and are circumscribed with a complete nodal capsule. Extracapsular dissection was advocated as adequate therapy. In rare cases with positive surgical margins, a completion parotidectomy or adjuvant radiotherapy should follow. Heterotopic high-grade AcCCs are rare, necessitating radical surgery including neck dissection and adjuvant radiotherapy. The short term prognosis is excellent, long term outcomes are not known. Longer term follow-up is essential.

Keywords: acinic cell carcinoma, heterotopia, lymph node, salivary gland

Received: August 15, 2020; Revised: September 23, 2020; Accepted: October 5, 2020; Prepublished online: November 12, 2020; Published: March 12, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Starek, I., Salzman, R., & Skalova, A. (2021). Heterotopic acinic cell carcinoma and its clinical implications. Biomedical papers, 165(1), 13-18. doi: 10.5507/bp.2020.047
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Haemel A, Gnepp DR, Carlsten J, Robinson-Bostom L. Heterotopic salivary gland tissue in the neck. J Am Acad Dermatol 2008;58:251-56. Go to original source... Go to PubMed...
    2. Marshall JN, Soo G, Coakley FV Ectopic salivary gland in the posterior triangle of the neck. J Laryngol Otol 1995;109:669-70. Go to original source... Go to PubMed...
    3. Maffini F, Pisa E, Possanzini P, Viale G Salivary gland choristoma of breast. Breast J 2012;18:181. Go to original source... Go to PubMed...
    4. Offner FA, Langner C. Heterotopic tissue in the gastrointestinal tract. Pathologe 2018;39:402-408. Go to original source... Go to PubMed...
    5. Marwah S, Berman ML. Ectopic salivary gland in the vulva (Choristoma): Report of a case and review of the literature. Obstet Gynecol 1980;56:389-91. Go to PubMed...
    6. McHugh JB. Major and minor salivary glands. In: Goldblum JR, Lamps LW, McKenny JK. Myers JL (eds) Rosai and Ackerman´s Surgical Pathology, 11th edn. Elsevier, Philadelphia, 2018, pp 38-45.
    7. Brown RB, Captain MC, Gaillard RA, Turner JA. The significance of aberrant or heterotopic parotid gland tissue in lymph nodes. Ann Surg 1953;138:850-56. Go to original source... Go to PubMed...
    8. Shinohara M, Harada T, Nakamura S, Oka M, Tashiro H. Heterotopic salivary gland tissue in lymph nodes of the cervical region. Int J Oral Maxillofac Surg 1992;21:166-71. Go to original source... Go to PubMed...
    9. Seifert G. Primäre Speicheldrüsentumoren in Lymphknoten der Parotis. Pathologe 1997;18:141-46. Go to original source... Go to PubMed...
    10. Warnock GR, Jensen JL, Kratochvil FJ. Developmental diseases. In. Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, 1991.
    11. Daniel, E, McGuirt WF. Neck massess secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol 2005;26:96-100. Go to original source... Go to PubMed...
    12. , Gudbrandsson FK, Liston SL, Maisel RA. Heterotopic salivary tissue in the neck. Otolaryngol Head Neck Surg 1982;90:279-82.
    13. Ferlito A., Bertino G., Rinaldo A., Mannara GM, Devaney KO. A review of heterotopia and associated salivary gland neoplasms of the head and neck. J Laryngol Otol 1990;113:299-303. Go to original source... Go to PubMed...
    14. Singer MI, Applebaum EL, Loy KD. Heterotopic salivary tissue in the neck. Laryngoscope 1979;89:1772-78. Go to original source... Go to PubMed...
    15. Teymoortash A, Ramaswamy A, Werner JA. Adenoidzystisches Karzinom im heterotopen Speicheldrüsengewebe der zervikalen Lymphknoten. Laryngo-Rhino-Otologie 2007;86:44-47. Go to original source... Go to PubMed...
    16. Zajtchuk CJ, Patow CA, Hyams VJ. Cervical heterotopic salivary gland neoplasms: a diagnostic dilemma. Otolaryngol Head Neck Surg 1982;90:178-81. Go to original source... Go to PubMed...
    17. Marucci DD, Lawson K, Harper J, Sebire NJ, Dunaway DJ. Sialoblastoma Arising in Ectopic Salivary Gland Tissue. J Plast Reconstr Aesthet Surg 2009;62:241-46. Go to original source... Go to PubMed...
    18. Suzuki H, Hashimoto K. Salivary duct carcinoma in the mandible: Report of a case with immunohistochemical studies J Oral Maxillofac Surg 1999;37:67-69. Go to original source... Go to PubMed...
    19. Brookstone BS, Huvos AG, Spiro RH. Central Adenoid Cystic Carcinoma of the Mandible. Oral Maxillofac Surg 1990;48:1329-33. Go to original source... Go to PubMed...
    20. Martinoli C, Cittadini G, Derchi LE, Rollandi GA, Chiaramondia M. Malignant Myoepithelioma Arising in Salivary Tissue on the Masseter Muscle: US, CT, and MR Findings. J Comput Assist Tomogr 1996;20:119-21. Go to original source... Go to PubMed...
    21. Perzin, KJ, Livolsi VA. Acinic cell carcinoma arising in ectopic salivary gland tissue. Cancer 1980;45:967-72. Go to original source...
    22. Michal M, Skálová A., Simpson RHW, Ry¹ka A, Stárek I. Well differentiated acinic cell carcinoma of salivary glands associated with lymphoid rich stroma. Hum Pathol 1997;28:595-600. Go to original source... Go to PubMed...
    23. Abdelkrim SB, Kermani W, Beizig N, Ziadi S, Belkadhi M, Sriha B, Mokni M. Acinic cell carcinoma with lymphoid stroma mistaken for a metastatic intraparotid lymph node at frozen section analysis. J Case Reports in Practice (JCRP) 2013;2:41-44.
    24. NCCN Guidlines Version 1.2015. Salivary gland tumors.
    25. Simpson RHW, Chiosea S, Katabi N. Acinic cell carcinoma. In: El-Naggar AK, Chan JKC, Grandis JR, Slootweg PJ, eds. World Health Organization (WHO) Classification of Head and Neck Tumours, 4th edition. IARC Press, Lyon, France 2017. pp 166-167.
    26. Vander Poorten V, Triantafyllou A, Thompson LDR, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP et al. Salivary acinic cell carcinoma: reappraisal and update. Eur Arch Otorhinolaryngol 2016;273:3511-31. doi: 10.1007/s00405-015-3855-7 Go to original source... Go to PubMed...
    27. Abrams AM, Cornyn J, Scoffield HH, Hansen LS. Acinic cell adenocarcinoma of the major salivary glands. A clinicopathologic study of 77 cases. Cancer 1965;18:1145-62. Go to original source...
    28. Evans RW, Cruickshank AH. Epithelial tumours of the salivary glands. Major Probl Pathol 1970;1:1-299. Go to PubMed...
    29. Bhaskar SN. Acinic cell carcinoma of salivary glands. Report of twenty-one cases. Oral Surg Oral Med Oral Pathol 1964;17:62-74. Go to original source... Go to PubMed...
    30. Kleinsasser O, Hubner G, Klein HJ. Acinuszelltumoren der Glandula parotis. Arch Klin Exper Ohren, Nasen und Kehlkopfheilk. 1967;33-50. Go to original source...
    31. Yacoub U, Carstens PH, Biscopink RJ, McMurry GT. Acinic-cell tumor in ectopic salivary-gland tissue. Arch Pathol Lab Med 1981;105(9):500-501
    32. Minic AJ. Acinic cell carcinoma arising in a parotid lymph node. Int J Oral Maxillofac Surg 1993; 22:289-291. Go to original source... Go to PubMed...
    33. Das R, Nath G, Bohara S, Bhattacharya AB, Gupta V. Two unusual cases of acinic cell carcinoma: role of cytoogy with histological corelation. J Clin Diagn Res 2016;:21-22. doi: 10.7860/JCDR/2016/19753.8374 Go to original source... Go to PubMed...
    34. Alsayegh OR, Qazi I, Almurshed M, Al Mutairi MM, Alquanaee M. Acinic cell carcinoma primarily arising in ectopic salivary gland tissue within an intra-parotid lymph node: A case report. Otolaryngol (Sunnyvale) 2018;8(346):2. doi: 10.4172/2161-119X.1000346. Go to original source...
    35. Biron VL, Lentsch EJ, Gerry DR, Bewley AF. Factors influencing survival in acinic cell carcinoma: a retrospective survival analysis of 2061 patients. Head Neck 2015;37:870-77. Go to original source... Go to PubMed...
    36. Hoffman HT, Karnell LH, Robinson RA, Pinkston JA, Menck HR. National cancer data base report on cancer of the head and neck: acinic cell carcinoma. Head Neck 1999:297-309. Go to PubMed...
    37. Patel NR, Sanghvi S, Khan MN, Husain Q, Baredes S, Eloy JA. Demographic trends and disease-specific survival in salivary acinic cell carcinoma: an analysis of 1129 cases. Laryngoscope 2014;124:172-78. Go to original source... Go to PubMed...
    38. Neskey DM, Klein JD, Hicks S, Garden AS, Bell DM, El-Naggar AK, Kies MS, Weber RS, Kupferman ME. Prognostic factors associated with decreased survival in patients with acinic cell carcinoma. JAMA Otolaryngol Head Neck Surg 2013;139:1195-202. Go to original source... Go to PubMed...
    39. Yoshida EJ, Garcia J, Eisele DW, Chen AM. Salivary gland malignancies in children. Int J Pediatr Otorhinolaryngol 2014;78:174-78. Go to original source... Go to PubMed...
    40. Spiro RH, Huvos AG, Strong EW. Acinic cell carcinoma of salivary origin. A clinicopathologic study of 67 cases. Cancer 1978;41:924-35 Go to original source...
    41. Gomez DR, Katabi N, Zhung J, Wolden SL, Zelefsky MJ, Kraus DH, Shah JP, Wong RJ, Ghossein RA, Lee NY. Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer 2009;115:2128-37. Go to original source... Go to PubMed...
    42. Skalova A, Sima R, Vanecek T, Muller S, Korabecna M, Nemcova J, Elmberger G, Leivo I, Passador-Santos F, Walter J, Rousarova M, Jedlickova K, Curik R, Geierova M, Michal M. Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/Neu genes. Am J Surg Pathol 2009;33:1137-45 Go to original source... Go to PubMed...
    43. Miki H, Masuda E, Ohata S, Komaki K, Hirokawa M. Late recurrence of acinic cell carcinoma of the parotid gland. J Med Invest 1999;46:213-16. Go to PubMed...
    44. Hutchinson JC Jr. Acinic cell carcinoma of minor salivary gland origin. Am J Otolaryngol 1981;2:54-58. Go to original source... Go to PubMed...
    45. McGurk M. Extracapsular dissection for clinically benign parotid lumps reduced morbidity without oncological compromise. BJC 2003;89:1610-13. Go to original source... Go to PubMed...
    46. Mantsopoulos K, Mueller S, Goncalves M, Koch M, Iro H. Completion surgery after extracapsular dissection of low grade parotid gland malignant tumors. Head Neck 2019;41:3383-88. doi: 10.1002/hed.2586 Go to original source... Go to PubMed...
    47. Mantsopoulos K, Koch M, Iro H. Extracapsular dissection as sole therapy for small low-grade malignant tumors of the parotid gland. Laryngoscope 2017;127:1804-7. doi: 10.1002/lary.26482 Go to original source... Go to PubMed...
    48. Bernier JL, Bhaskar SN. Lymphoepithelial lesions of salivary glands. Histogenesis and classification based on 186 cases. Cancer 1958;11:1156-79. Go to original source...
    49. Perzin KH, Livolsi VA. Acinic cell carcinomas arising in salivary glands: a clinicopathologic study. Cancer 1979;44:1434-57. Go to original source...
    50. Jensen LM, Kiaer H. Acinic cell carcinoma with primary presentation in an intraparotid lymph node. Pathol Res Pract 192;188:226-31.

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content