Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(3):292-299 | DOI: 10.5507/bp.2019.026

HPV, protein p16 and squamous cell carcinoma of the oral cavity

Jiri Blahaka, Jiri Zelinkaa, Jaromir Gumulecc, Ctirad Machacekb, Zdenek Daneka, Oliver Bulika
a Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
b Department of Pathology, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
c Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear.

Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading.

Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66).

Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.

Keywords: oral squamous cell carcinoma, oral cancer, HPV, human papilloma virus, p16

Received: February 24, 2019; Revised: May 15, 2019; Accepted: May 28, 2019; Prepublished online: June 17, 2019; Published: September 17, 2020  Show citation

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Blahak, J., Zelinka, J., Gumulec, J., Machacek, C., Danek, Z., & Bulik, O. (2020). HPV, protein p16 and squamous cell carcinoma of the oral cavity. Biomedical papers, 164(3), 292-299. doi: 10.5507/bp.2019.026
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