Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020, 164(2):161-167 | DOI: 10.5507/bp.2019.007

Safe and effective percutaneous ethanol injection therapy of 200 thyroid cysts

Milan Halenka, David Karasek, Jan Schovanek, Zdenek Frysak
Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology
Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic

Introduction: Ultrasound-guided percutaneous ethanol injection therapy (US-PEIT) is a minimally invasive procedure that may be performed as an alternative to surgery for the treatment of recurrent symptomatic thyroid cysts for which simple aspiration failed. The present study aimed at assessing US-PEIT in a large cohort of patients, identifying factors influencing treatment outcome.

Methods: Retrospective analysis of 193 patients with 200 thyroid cysts who underwent US-PEIT in 2004-2018.

Results: The initial median cyst volume was 8.5 mL [5.5-16.0]; median final volume at 12 months after the completion of therapy was 0.5 mL [0.2-1.3]. A Volume Reduction Rate (VRR) of 95.0% [86.7-98.0] was achieved. For successful US-PEIT, relatively small total amount of ethanol was needed, on average corresponding to 20.0% [16.7-28.6] of the initial cyst volume. VRR positively correlated with the initial cyst volume and negatively with the presence of complex cyst. Multiple regression analysis showed the presence of complex cyst as an independent predictor of treatment efficacy.

Conclusion: US-PEIT of thyroid cysts of all sizes was very successful with using total amounts of ethanol, corresponding to ≈20% of the initial cyst volume.

Keywords: thyroid cyst, ultrasound-guided percutaneous ethanol injection therapy, volume reduction rate

Received: January 3, 2019; Revised: February 28, 2019; Accepted: February 28, 2019; Prepublished online: March 29, 2019; Published: June 18, 2020  Show citation

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Halenka, M., Karasek, D., Schovanek, J., & Frysak, Z. (2020). Safe and effective percutaneous ethanol injection therapy of 200 thyroid cysts. Biomedical papers, 164(2), 161-167. doi: 10.5507/bp.2019.007
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