Biomedical papers, 2017 (vol. 161), issue 1

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017, 161(1):54-57 | 10.5507/bp.2017.005

A patient called Medical Research

Tomas Fursta, Jan Strojilb
a Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacky University Olomouc, Czech Republic
b Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

We report the case of a patient called Medical Research who presents with multiple life threatening symptoms, including a plethora of false positive results. This paper describes the course of the disease, discusses possible etiologies and offers options for future management to ensure the survival of the patient and that of our civilization.

Keywords: reproducibility crisis, perverse incentives, P value, publication bias, frequentist, Bayesian

Received: January 26, 2017; Accepted: February 23, 2017; Prepublished online: March 14, 2017; Published: March 27, 2017


References

  1. Ferguson N. Civilization: The West and the Rest. Penguin, 2011.
  2. Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature 2012;483(7391):531-3. doi: 10.1038/483531a Go to original source... Go to PubMed...
  3. Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 2011;10(9):712. doi: 10.1038/nrd3439-c1 Go to original source... Go to PubMed...
  4. Perrin S. Preclinical research: Make mouse studies work. Nature 2014;507(7493):423-5. Go to original source... Go to PubMed...
  5. Eklund A, Nichols TE, Knutsson H. Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci U S A 2016;113(28):7900-5. doi: 10.1073/pnas.1602413113 Go to original source... Go to PubMed...
  6. Ioannidis JPA. Why most published research findings are false? PLoS Med 2005;2(8):e124. Go to original source... Go to PubMed...
  7. Schroter S, Black N, Evans S, Godlee F, Osorio L, Smith R. What errors do peer reviewers detect, and does training improve their ability to detect them? J R Soc Med 2008;101(10):507-14. doi: 10.1258/jrsm.2008.080062. Go to original source... Go to PubMed...
  8. Bohannon J. Who's afraid of peer review? Science 2013;342(6154):60-5. doi: 10.1126/science.342.6154.60 Go to original source... Go to PubMed...
  9. Bishop C. Pattern Recognition and Machine Learning. New York: Springer, 2007.
  10. Wasserstein RL, Lazar NA. The ASA's Statement on p-Values: Context, Process, and Purpose. Am Stat 2016;70(2):129-33. doi: 10.1080/00031305.2016.1154108 Go to original source...
  11. Woolston C. Psychology journal bans P values. Nat News 2015;519(7541):9. Go to original source...