Biomedical papers, 2016 (vol. 160), issue 4

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):533-537 | 10.5507/bp.2016.051

Congenital bronchopulmonary malformation: CT histopathological correlation

Martin Kyncla, Martin Kocia, Lea Ptackovaa, Ludmila Hornofovab, Ondrej Fabianb, Jiri Snajdaufc, Miloslav Roceka, Marcela Pychovac
a Department of Radiology, 2nd Faculty of Medicine, Charles University in Prague and Faculty Hospital Motol, Prague, Czech Republic
b Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Faculty Hospital Motol, Prague, Czech Republic
c Department of Paediatric Surgery, 2nd Faculty of Medicine, Charles University in Prague and Faculty Hospital Motol, Prague, Czech Republic

Background: This study evaluated the accuracy of postnatal computed tomography (CT) imaging in the identification of congenital bronchopulmonary malformation (BPM) in comparison with histopathological analysis.

Methods: CT scans of prenatally diagnosed BPMs from 24 patients with available histology were analysed retrospectively. The CT images were reviewed blinded to histological findings by two radiologists. Specific diagnosis was assigned based on predetermined criteria. The accuracy of CT was evaluated.

Results: The agreement rate in CT diagnosis between two radiologists was 100%. In 75% the lesions were located in the lower lobes. An overlap of 71% in CT and histopathological diagnoses was reached. The least matching diagnosis was type 2 CPAM.

Conclusion: Contrast enhanced chest CT is very accurate in characterizing the BPM spectrum and provides important information on lesion type and structure.

Keywords: bronchopulmonary malformation, computed tomography, histopathological findings, predetermined criteria

Received: June 5, 2016; Accepted: September 27, 2016; Prepublished online: October 17, 2016; Published: December 12, 2016


References

  1. Epelman M, Kreiger P, Servaes S, Victoria T, Hellinger J. Current imaging of prenatally diagnosed congenital lung lesions. Semin Ultrasound, CT MRI 2010;31(2):141-57. doi:10.1053/j.sult.2010.01.002 Go to original source... Go to PubMed...
  2. Newman B. Congenital bronchopulmonary foregut malformations: concepts and controversies. Pediatr Radiol 2006;36(8):773-91. doi:10.1007/s00247-006-0115-4 Go to original source... Go to PubMed...
  3. Bush A. Congenital lung disease: A plea for clear thinking and clear nomenclature. Pediatr Pulmonol 2001;32(4):328-37. doi:10.1002/ppul.1126 Go to original source... Go to PubMed...
  4. Fowler D, Gould S. The pathology of congenital lung lesions. Semin Pediatr Surg 2015;24(4):176-82. doi:10.1053/j.sempedsurg.2015.02.002 Go to original source... Go to PubMed...
  5. Langston C. New Concepts in the Pathology of Congenital Lung Malformations. 2003;12(1):17-37.
  6. Lee E, Boiselle P, Cleveland R. Multidetector CT evaluation of congenital lung anomalies. Radiology 2008;247(3):632-48. doi:10.1148/radiol.2473062124 Go to original source... Go to PubMed...
  7. Stocker J, Madewell J, Drake R. Congenital cystic adenomatoid malformation of the lung. Classification and morphologic spectrum. Hum Pathol 1977;8(2):155-71. http://www.ncbi.nlm.nih.gov/pubmed/856714. Accessed April 18, 2016. Go to original source... Go to PubMed...
  8. Kunisaki S, Fauza D, Nemes L, Barnewolt CE, Estroff JA, Kozakewich HP, Jennings RW. Bronchial atresia: The hidden pathology within a spectrum of prenatally diagnosed lung masses. J Pediatr Surg 2006;41(1):61-5. doi:10.1016/j.jpedsurg.2005.10.082 Go to original source... Go to PubMed...
  9. Riedlinger W, Vargas S, Jennings R, Estroff JA, Barnewolt CE, Lillehei CW, Wilson JM, Colin AA, Reid LM, Kozakewich HP. Bronchial atresia is common to extralobar sequestration, intralobar sequestration, congenital cystic adenomatoid malformation, and lobar emphysema. Pediatr Dev Pathol 2006;9(5):361-73. doi:10.2350/06-01-0023.1 Go to original source... Go to PubMed...
  10. Pacharn P, Kline-Fath B, Calvo-Garcia M, Linam LE, Rubio EI, Salisbury S, Brody AS. Congenital lung lesions: Prenatal MRI and postnatal findings. Pediatr Radiol 2013;43(9):1136-43. doi:10.1007/s00247-013-2668-3 Go to original source... Go to PubMed...
  11. Boucherat O, Jeannotte L, Hadchouel A, Delacourt C, Benachi A. Title: Pathomechanisms of Congenital Cystic Lung Diseases: Focus on Congenital Cystic Adenomatoid Malformation and Pleuropulmonary Blastoma. 2016;16:62-8. doi:10.1016/j.prrv.2015.11.011 Go to original source...
  12. Koci M. Espr 2015. Pediatr Radiol 2015;45(S2):332. doi:10.1007/s00247-015-3337-5 Go to original source...
  13. Bush A, Hogg J. Cystic lung lesions - prenatal diagnosis and management. Prenat Diagn 2008;28(10):604-11. doi:10.1002/pd.2039 Go to original source... Go to PubMed...
  14. Meizner I, Rosenak D. The vanishing foetal intrathoracic mass: consider an obstructing mucous plug. Ultrasound Obstet Gynecol 1995;5(4):275-7. doi:10.1046/j.1469-0705.1995.05040275.x Go to original source... Go to PubMed...
  15. Kunisaki S, Ehrenberg-Buchner S, Dillman J, Smith E, Mychaliska G, Treadwell M. Vanishing foetal lung malformations: Prenatal sonographic characteristics and postnatal outcomes. J Pediatr Surg 2015;50(6):978-82. doi:10.1016/j.jpedsurg.2015.03.025 Go to original source... Go to PubMed...
  16. Barth R. Airway Anomalies, Lung and Mediastinal Masses, and Hydrothorax. In: Kline-Fath B, ed. Fetal Imaging Ultrasound and MRI 1st ed. Philadelphia, PA: Wolters Kluwer Health; 2015:596-601.
  17. Lanza C, Bolli V, Galeazzi V, Fabrizzi B, Fabrizzi G. Malformazione adenomatoide-cistica in et pediatrica: Correlazione tra aspetti TC e reperti istopatologici. Radiol Medica 2007;112(4):612-9. doi:10.1007/s11547-007-0166-0 Go to original source...
  18. Zeidan S, Gorincour G, Potier A, Ughetto F, Dubus JC, Chrestian MA, Grosse C, Gamerre M, Guys JM, de Lagausie P. Congenital lung malformation: evaluation of prenatal and postnatal radiological findings. Respirology 2009;14(7):1005-11. doi:10.1111/j.1440-1843.2009.01591.x Go to original source... Go to PubMed...