Biomedical papers, 2016 (vol. 160), issue 4

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):474-483 | 10.5507/bp.2016.036

SPECT/CT imaging in breast cancer - current status and challenges

Milan Simaneka, Pavel Korandab
a Department of Nuclear Medicine, Regional Hospital Pelhrimov, Czech Republic
b Department of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

Background: The increasing incidence of breast cancer worldwide raises the importance of improving imaging techniques for disease stratification after early lesion detection. SPECT/CT imaging is now widely available but its diagnostic potential is not fully utilized for more specific purposes including breast cancer patient stratification.

Methods and Results: A Pubmed search for both original and review articles related to the value of SPECT/CT in breast cancer patients and comparison to other diagnostic methods. 62 articles were found using the key words SPECT/CT, Fusion Image and Breast Cancer. Development of a new generation of SPECT/CT systems and their introduction into practice has changed the old diagnostic algorithm. The increasing importance of SPECT/CT in the detection of bone metastases is confirmed. The diagnostic accuracy of new SPECT/CT instruments in the diagnostics of bone metastases is nearly comparable to PET/CT scans. SPECT/CT is more widely available and costs less than PET. It is able not only to identify a sentinel lymph nodes in atypical localizations but also to detect sentinel lymph nodes non visualized on previous planar scans. SPECT/CT offers precise anatomic localization of sentinel lymph nodes, thereby facilitating surgery. Knowledge of precise sentinel lymph node localization can also be applied in radiotherapy.

Conclusions: The role of hybrid SPECT/CT imaging in breast cancer patients is changing. It is a powerful modality for skeletal and nodal staging in breast cancer patients with important impact on therapy.

Keywords: breast neoplasms, sentinel lymph node biopsy, neoplasm metastasis, multimodal imaging, SPECT/CT

Received: May 9, 2016; Accepted: June 28, 2016; Prepublished online: August 2, 2016; Published: December 12, 2016


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