Biomedical papers - Latest articles
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Postcovid Guillain-Barré syndrome with severe course - case series two patients including clinical evaluation of smell and examination of olfactory event-related potentials (OERPs)Case report
Nikola Pastorkova, Karla Janouskova, Libor Vasina, Helene Schulz, Jaromir Astl, Richard Holy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):354-358 | DOI: 10.5507/bp.2023.014 
This work presents case reports of two patients with Guillain-Barré syndrome associated with previous COVID19 that both patients survived. The sense of smell was investigated subjectively using sniffin' stick tests and objectively using objective olfactometry by the evaluation of olfactory event-related potentials (OERPs). Despite the severe course of post-covid GBS, no olfactory disturbance was detected. Both patients had good results on the smell tests. OERPs were plentiful in both cases.
Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center studyOriginal papers
Matej Halaj, Ondrej Kalita, Lucie Tuckova, Lumir Hrabalek, Martin Dolezel, Jana Vrbkova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):349-353 | DOI: 10.5507/bp.2023.030
Progress in the of diagnostic and neurosurgical techniques of the last decade have enabled even safe resection of suspected GBMs located in eloquent brain regions. Currently, patients indicated for only the needle biopsy represent a minority group with a common poor prognosis. The purpose of stereotactic biopsy is to obviate misdiagnosis and to choose the optimal treatment strategy. The aim of this paper is to evaluate life expectancy in patients with GBM confirmed by needle biopsy and the relationship with the following oncotherapy. Patients in this study who had undergone oncotherapy, had a slight increase in overall survival. The effect of this treatment was enhanced in patients with favourable clinical factors such as age and Karnofsky score.
Occult fractures detected on radiographs in young children with a concern for abusive head traumaOriginal papers
Eliska Popelova, Zuzana Holubova, Marcela Dvorakova, Martin Kyncl
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):342-348 | DOI: 10.5507/bp.2023.018
Identifying infants and toddlers with abusive head trauma is challenging. Finding any evidence of trauma in these children is therefore very important. Dedicated skeletal radiographs of the whole skeleton should be performed in all children younger than two years evaluated for possible abuse. Our study showed that dedicated skeletal radiographs were only performed in 62% of children younger than two years evaluated for suspected abusive head trauma. Clinically occult fractures were revealed in 31% of these children. Moreover, the majority of these fractures had high specificity for abuse. Attention should be paid to increasing awareness of child abuse imaging protocols.
The association between preterm births and assisted reproductive technologiesOriginal papers
Anna Stastna, Eva Waldaufova, Tomas Fait
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):332-341 | DOI: 10.5507/bp.2023.039
While assisted reproductive technology (ART) offers hope to millions of couples worldwide in overcoming infertility, it also attracts attention to investigating the health outcomes of mothers and their children. Using Cox regression models, this study compares preterm birth risk between ART-assisted singleton pregnancies (in-vitro fertilisation (IVF) with fresh embryo transfer, frozen embryo transfer (FET) and oocyte receipt (OoR)) with non-ART singleton pregnancies. The results show a higher preterm birth risk in ART-treated women (1.56 to 2.06 depending on the ART method) compared to women without ART treatment. However, no statistically significant differences were found in the risk of preterm birth among ART-treated mothers based on specific ART methods.
Fetal magnetic resonance imaging in the confirmation of congenital anomalies found on routine mid-trimester ultrasoundOriginal papers
Ishraq Dhaifalah, Marek Godava, Jana Havalova, Pavla Hanzlikova, Kamila Michalkova, Lenka Bakaj Zbrozkova, Jakub Civrny, Howard Cuckle
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):326-331 | DOI: 10.5507/bp.2024.008
Most pregnant women are offered a routine ultrasound scan during the second trimester of pregnancy in order to detect fetal anomalies. In some cases, an anomaly suspected by ultrasound requires referral for a fetal magnetic resonance imaging (MRI) examination in order to clarify the diagnosis. In this study a large series of such referrals was assessed, accounting for one in six women with a fetal anomaly on ultrasound. In general, the MRI findings supported the scan results but this varied according to the type of anomaly. This concordance was very high for anomalies of the urinary tract and face.
Gamma-glutamyltransferase-associated glycoprotein patterns in human seminal plasma of normozoospermic men: a new aspect of biomarker heterogeneityOriginal papers
Tamara Jankovic, Jelena Danilovic Lukovic, Sanja Goc, Ninoslav Mitic, Ljiljana Hajdukovic, Miroslava Jankovic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):319-325 | DOI: 10.5507/bp.2023.031
Gamma-glutamyltransferase (GGT) is implicated in a variety of diseases, but it is not extensively studied in relation to reproductive physiology. An increase in GGT activity is associated with alterations in a specific fractional pattern of distinct molecular mass forms. In this study, seminal GGT forms were estimated and, for the first time, annotated with underlying patterns of sialylated and mannosylated glycoproteins. The GGT-associated glycoprotein patterns were established as an adjunct reference parameter to differentiate between known GGT molecular mass forms. These emerge as new targets for evaluation of its biomarker potential.
The renoprotective effect of Tibolone in sepsis-induced acute kidney injuryOriginal papers
Ejder Saylav Bora, Duygu Burcu Arda, Oytun Erbas
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):311-318 | DOI: 10.5507/bp.2024.016
This study breaks new ground by investigating Tibolone’s potential as a therapeutic agent in sepsis-induced acute kidney injury (AKI), an area largely unexplored previously. By delving into Tibolone’s effects on biomarkers like SIRT1 and YAP, as well as its impact on inflammatory and oxidative processes, it sheds light on its promising role in mitigating renal damage. The findings underscore Tibolone’s potential as a novel intervention for sepsis-associated AKI, urging further research for translational application in clinical settings.
Comparison of dose length product and image quality of a biphasic whole-body polytrauma CT protocol with and without the automatic tube voltage selectionOriginal papers
David Girsa, Karin Kremenova, Jiri Lukavsky, Lucie Sukupova, Hana Malikova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):304-310 | DOI: 10.5507/bp.2024.004
This work has shown that in terms of reducing the radiation load of the two-phase whole-body CT protocol used in the examination of polytraumatic patients, there is no difference whether we use only the function of automatic current modulation on the X-ray tube, or its combination with the function of automatic voltage selection. In the case of a combination of both functions, the image quality drops slightly. Significantly more important for the radiation load is the position of the patient's arms during the examination: if the arms are in the scanned volume along the body, the radiation load is significantly higher in both examined groups.
Safety and efficacy of simple training protocol in patients after mild traumatic brain injuryOriginal papers
Martina Martinikova, Robert Ruzinak, Petra Hnilicova, Michal Bittsansky, Marian Grendar, Lucia Babalova, Pavol Skacik, Ema Kantorova, Vladimir Nosal, Monika Turcanova Koprusakova, Jozef Sivak, Jana Sivakova, Zuzana Biringerova, Branislav Kolarovszki, Kamil Zelenak, Egon Kurca, Stefan Sivak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):295-303 | DOI: 10.5507/bp.2023.013
In this paper, the authors show that simple physical and cognitive training after mild traumatic brain injury (mTBI) can be positive for the brain and its functions and help in the prevention of post-concussion syndrome. This can lead to the decreased economic burden of mTBI, and individual training can be performed without professional supervision.
S100B protein as a biomarker and predictor in traumatic brain injuryOriginal papers
Stefan Trnka, Premysl Stejskal, Jakub Jablonsky, David Krahulik, Daniel Pohlodek, Lumir Hrabalek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):288-294 | DOI: 10.5507/bp.2023.025
Despite the known value of using S100B protein for its prognostic potential in cases of traumatic brain injury, the findings of this study are that the correlations between selected internal diseases, body habitus, season and S100B protein are not confirmed in TBI patients. Conversely, when interpreting the results of patients with polytrauma, it is important to remember that the S100B protein value is modified in this instance. A benefit that cannot be overlooked is that the S100B values are associated with good patient prognosis, offering therapeutic advantages in addition to the prognostic ones.
Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overviewReviews
David Solil, Petr Dite, Michal Senkyrik, Martina Bojkova, Bohuslav Kianicka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):284-287 | DOI: 10.5507/bp.2024.023
Early diagnosis of pancreatic cancer and successful treatment is difficult. The optimization strategy is linked to identifying the specific subgroups of pancreatitis. To improve prognosis, it is crucial to identify patients at risk, in other words patients following acute pancreatitis and those with recurrent acute pancreatitis. The risk for pancreatic cancer development is very high in patients who are positive for other risk factors such as obesity, metabolic syndrome, alcohol abuse, smoking etc.
Exploring the benefits and challenges of AI-driven large language models in gastroenterology: Think out of the boxReviews
Jan Kral, Michal Hradis, Marek Buzga, Lumir Kunovsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):277-283 | DOI: 10.5507/bp.2024.027
Artificial Intelligence (AI) has evolved significantly from its early concepts in the 1950s to today's advanced large language models (LLMs) like ChatGPT. This technology has the potential to revolutionize gastroenterology, including diagnosis, treatment, education, and decision-making support. The benefits to gastroenterology include accelerating diagnosis and treatment, providing personalized care, enhancing education, aiding decision-making, and improving patient communication. However, challenges like limited AI capability, biased data, errors, security and privacy concerns, and costs must be addressed. The future of LLMs in gastroenterology depends on processing large quantities of data, identifying patterns, and assisting in personalized treatment plans. Collaboration between AI developers, healthcare professionals, and regulatory bodies is essential for responsible use, ensuring LLMs support doctors and contribute to better patient care.
A severe case of pemphigoid gestationis persisting after labour - case report and review of the literatureCase report
Hynek Herman, Petr Krepelka, Adela T. Faridova, Klara Trojanova, Jiri Hanacek, Barbora Jaluvkova, Jaroslav Feyereisl, Spyridon Gkalpakiotis
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):271-275 | DOI: 10.5507/bp.2023.010
The communication on pemphigoid gestationis is of paramount importance not only because of the need to report such a serious disease in a professional journal, but also as a recommendation for possible treatment of this rare condition in pregnancy which a large number physicians and especially obstetricians may not encounter in their entire careers. As with other diseases, early and accurate diagnosis and subsequent early therapy is of primary importance, to obviate major deterioration in the condition, the risk to the pregnant woman and the fetus, and to the newborn after delivery.
The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021Original papers
Dominika Stastna, Jiri Drahota, Michal Lauer, Aneta Mazouchova, Ingrid Menkyova, Jana Adamkova, Radek Ampapa, Michal Dufek, Marketa Grunermelova, Pavel Hradilek, Eva Kubala Havrdova, Jan Mares, Alena Martinkova, Zbysek Pavelek, Marek Peterka, Eva Recmanova, Petra Rockova, Ivana Stetkarova, Pavel Stourac, Marta Vachova, Dana Horakova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):262-270 | DOI: 10.5507/bp.2023.015
Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. These findings come from the Czech National Multiple Sclerosis Registry ReMuS which provides a quality source of data for not only scientific publications, but national regulatory authorities as well. Its outputs offer feedback and a means for improving the management of multiple sclerosis in the future.
Point-of-care ultrasound (POCUS) in acute hospitalized older patients focused on hydrationOriginal papers
Vladimir Hrabovsky, Martina Skrobankova, Zdenek Lys, Adela Vrtkova, Veronika Spacilova, Jan Vaclavik
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):256-261 | DOI: 10.5507/bp.2023.038
Ultrasound examination is non-invasive, simple to perform and it provides valuable information on a patient´s condition, including geriatric. Patients as older individuals frequently suffer from dehydration. This study showed that ultrasound assessment provides immediate key information for comprehensive understanding of clinical status in older patients and can be beneficial for optimizing the treatment strategy, including fluid management decisions.
Changes in vascular density in the macula after pars plana vitrectomy for idiopathic macular hole with macular peeling and one type of flapOriginal papers
Anna Tarkova, Nada Jiraskova, Jaroslava Dusova, Jan Marak, Jan Studnicka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):248-255 | DOI: 10.5507/bp.2023.017
In this study, the authors focused on changes in the vascular density of the superficial and deep vascular plexus in temporal and foveal-sparing flap after pars plana vitrectomy (PPV) with macular peel. The vascular density of the deep plexus increased in both groups and the vascular density of the superficial plexus was almost the same in the temporal flap and in the foveal-sparing flap was reduced during the one-year follow-up period. The results were also confirmed by the anatomical improvement. The authors demonstrated a statistical relationship between the duration of symptoms and changes in the microvasculature in the macula in both groups. No significant differences were found between the various forms of the flap method used in PPV.
A stylet use may be beneficial for elective and rescue intubation of prematurely born infants < 30 weeksOriginal papers
Klara Dunajova, Tereza Lamberska, Truong An Nguyen, Adam Kubica, Petr Kudrna, Richard Plavka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):243-247 | DOI: 10.5507/bp.2024.015
This study challenges the prevailing view that stylet use during intubation offers no benefit, specifically in the context of premature infants in the delivery room. Through the detailed analysis of 104 intubation attempts across 70 infants, the authors found that employing a stylet significantly enhances the success rate of initial intubation attempts, shortens the procedure's duration, and lowers the risk of severe desaturation events. The evidence suggests that the use of a stylet could be significant for stabilization of extremely premature infants during the golden hour of their life, marking a significant shift in current practices for this vulnerable population.
Severe congenital T-lymphocytopenia may affect the outcome of neonatal intensive careOriginal papers
Ivana Hulinkova, Veronika Medova, Andrea Soltysova, Veronika Dobsinska, Andrej Ficek, Peter Ciznar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):235-242 | DOI: 10.5507/bp.2023.028
This study evaluated the amount of TREC in a group of risk newborns and found a significant association between low TREC values and the occurrence of sepsis. The authors identified an association between mortality in preterm neonates with sepsis in patients with TREC < 5th percentile and they hypothesize that low TREC values may be a surrogate marker for mortality in preterm neonates.
A comparison of heart failure patients with reduced ejection fraction in the Moravian Midlands Registry with the LCZ696 patients in the Paradigm-HF trialOriginal papers
Ludek Pavlu, Marek Vicha, Jakub Flasik, Jana Petrkova, Milos Taborsky, Tereza Kacirkova, Ondrej Holy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):229-234 | DOI: 10.5507/bp.2023.006
This study aspired to provide comprehensive real-world data on a population with heart failure in the Moravian region of the Czech Republic. The authors compared local clinically relevant data with those from the ground-breaking Paradigm-HF trial and they found that local patients had a more advanced state of heart failure. The high prevalence of implantable cardioverter-defibrillators (ICD) and cardiac resynchronization therapy (CRT) confirms access to advanced and financially demanding treatment options in this region.
Influence of graft anastomosis and graft morphology on long-term patency of the saphenous vein after aortocoronary bypassOriginal papers
Okaikor Okantey, Tomas Jonszta, Jiri Sieja, Miriam Kende, Radim Brat, Lubomir Pavliska
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):223-228 | DOI: 10.5507/bp.2024.013
Coronary artery bypass grafting (CABG) is a surgical modality that resolves ischemic myocardial disease. The success of the procedure depends on a number of factors. Construction of the anastomosis and graft characteristics play a functional role in graft patency. This follow-up analysis of a study on the effects of endoscopic vein harvest after bypass surgery compared the outcome of sequential anastomoses and single grafts, vein graft length and diameter, calcium score, and target artery quality on long-term vein graft patency. The differences between sequential and individual grafts were not statistically significant. Graft and target artery diameters had a statistically significant influence on patency. Longer graft lengths and higher calcium scores were associated with statistically significant graft occlusion.
Ultrasonographic signs as predictors of metastatic involvement in the axillary lymph nodes in breast cancer patients: from minimal changes to the appearance of the pathological lymph node. A retrospective analysisOriginal papers
Lucia Veverkova, Marketa Koleckova, Katherine Vomackova, Nora Zlamalova, Lubica Lowova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):216-222 | DOI: 10.5507/bp.2023.009
This is a retrospective analysis of ultrasound findings in axillary lymph nodes in the patients with newly diagnosed breast cancer. The study focuses on the minimal morphological changes as early signs of metastatic involvement. This could be the basis for the design of a scoring system to evaluate axillary lymph nodes apropos sonographic features and with regard to the type of primary breast cancer and its aggressiveness. This retrospective evaluation and research may contribute to better ultrasound evaluation of lymph nodes in breast cancer patients
Challenges with hippocampal MR spectroscopy as a surrogate for pre-radiotherapy assessment of neurocognitive impairment in patients with brain metastasisOriginal papers
Iveta Selingerova, Klara Holikova, Tomas Chodur, Ludmila Hynkova, Petr Pospisil, Martin Bulik, Renata Belanova, Kamila Siffelova, Ivana Kolouskova, Marek Slavik, Petr Burkon, Roman Hrstka, Radim Jancalek, Jiri Sana, Pavel Slampa, Tomas Kazda
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):206-215 | DOI: 10.5507/bp.2024.012
Patients with multiple brain metastases (BM) benefit from hippocampal-avoiding whole brain radiotherapy (HA-WBRT), a less available form of WBRT. This study explores pre-radiotherapy (pre-RT) hippocampal magnetic resonance spectroscopy (MRS) as a tool for assessing neurocognitive functions (NCF) in order to identify which patients may benefit from HA-WBRT. 43 BM patients underwent pre-RT hippocampal MRS, correlating N-acetylaspartate (neuronal density surrogate) with NCF tests (HVLT and BVMT). Borderline statistically significant correlations were found with speculative interpretation underlying the challenges of hippocampal MRS as a surrogate for neurocognitive impairment. Further studies are needed to validate hippocampal MRS as a predictor for memory sparing radiotherapy benefit.
Interventions for increasing medication adherence in heart failure patients: A narrative reviewReviews
Libor Jelinek, Jan Vaclavik, Marie Lazarova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):200-205 | DOI: 10.5507/bp.2024.022
Heart failure is one of the critical and most costly medical challenges of the 21st century. It is a chronic debilitating condition and adherence to medication, a precondition for successful treatment is often poor. There are various interventions for improving adherence. Depending on the goal of the intervention, these are roughly patient centric, healthcare provider centric and system centric. The authors provide an overview of these interventions with a focus on effectiveness and appropriateness in different clinical situations. Their use can lead to improved patient outcomes and reduced economic burden of the disease.
Chronic non-bacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO) with a focus on pamidronate therapyReviews
Katerina Bouchalova, Zuzana Pytelova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(3):191-199 | DOI: 10.5507/bp.2024.007
CNO/CRMO is a rare autoinflammatory bone disease of unknown etiology. The authors review the etiology, epidemiology, clinical course, diagnostic criteria, development of classification criteria, diagnostic methods, association with other diseases, methods for disease activity evaluation, treatment and tasks for the future. Tables comparing different diagnostic criteria, recently developed RINBO index (radiologic index for nonbacterial osteomyelitis) and summary of studies on CNO/CRMO therapy using pamidronate are included.
Macrotroponins cause discrepancy in high-sensitivity examinationCase reports
Pavel Broz, Jaroslav Racek, Pavel Prokop, Jaroslav Novak, Daniel Rajdl, Ladislav Trefil
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):187-190 | DOI: 10.5507/bp.2023.001
This work presents two cases of a discrepancy between clinical presentation and falsely elevated cardiac troponins concentrations. Cases like this are well known to laboratory professionals, however, according to the experience of the authors, clinical professionals are often not. Presentation of such cases to the wider medical community can help avoid unnecessary investigation and possible harm to patients.
Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literatureCase reports
Martina Spisarova, Stanislav Losse, Petr Jakubec, Igor Hartmann, Milan Kral, Jiri Ehrmann, Marek Szkorupa, Hana Studentova, Bohuslav Melichar
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):181-186 | DOI: 10.5507/bp.2022.051
Two cases of BCG pneumonitis described in this study highlight the necessity to consider systemic BCG infection in patients after intravesical BCG therapy. Uncommon complications of bacillus Calmette-Guérin administration could be very serious and threaten the life of patients treated with this modality. Treatment with specific antituberculotic medication underlines the importance of correct diagnosis.
Robotic assisted living donor nephrectomy - the first in the Czech RepublicCase reports
Pavel Zemla, Igor Hartmann, Frantisek Hruska, Milan Kral, Jana Janeckova, Petr Utikal, Ales Vidlar, Karel Krejcí, Petr Bachleda
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):177-180 | DOI: 10.5507/bp.2023.034
This work describes the first robotic assisted living donor nephrectomy in the Czech Republic which was performed in June 2022. Worldwide, this operation was first carried out in 2001 and has now become common practice at many workplaces. It not only provides all the advantages of a laparoscopic operation but it also adds other technical improvements and minimizes intraoperative stress on the surgeon. The authors believe this breakthrough in the Czech Republic will trigger an increase in robotic assisted kidney harvesting. This paper also incorporates our ten-year experience in living donor nephrectomies, conducted using various techniques.
B cell subsets reconstitution and immunoglobulin levels in children and adolescents with B non-Hodgkin lymphoma after treatment with single anti CD20 agent dose included in chemotherapeutic protocols: single center experience and review of the literatureOriginal papers
Eva Hlavackova, Zdenka Krenova, Arpad Kerekes, Peter Slanina, Marcela Vlkova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):167-176 | DOI: 10.5507/bp.2023.021
This is a retrospective one tertiary centre study which investigated the humoral and cellular immunity reconstitution and clinical impact of chemotherapeutic protocols that included a single rituximab dose in children and adolescents treated for non-Hodgkin Lymphoma. The proportion of IgG, IgM, and IgA hypogammaglobulinemia decreased over the follow-up period. The median for B cell reconstitution was 3 months after the end of lymphoma treatment. Transitional B lymphocyte subsets dominated at the time of B cell subset reconstitution. No secondary antibody deficiency needing immunoglobulin replacement therapy was found.
High incidence of acute and subacute ischaemic foci on brain MRI in patients with a diagnosis of acute pulmonary embolism and confirmed patent foramen ovaleOriginal papers
Radomir Nykl, Martin Hutyra, Eva Cechakova, Jan Precek, David Vindis, David Richter, Milos Taborsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):162-166 | DOI: 10.5507/bp.2023.005
The authors present an evaluation of 129 patients with a diagnosis of acute pulmonary embolism who were thoroughly examined (TTE, TEE, laboratory, brain MRI), They found a surprisingly high incidence of acute and subacute pathological findings on brain MRI in direct relation to the presence of PFO confirmed by TEE.
Utility of fine-needle aspiration biopsy (FNAB) in parotid pleomorphic adenoma diagnosis and managementOriginal papers
Alzbeta Fikova, Stepan Novak, David Kalfert, Martin Kuchar, Michal Zabrodsky, Lucie Dostalova, Jan Balko, Jan Plzak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(2):156-161 | DOI: 10.5507/bp.2023.027
The results confirmed, that ultrasound-guided fine-needle aspiration biopsy (FNAB) is valuable in the diagnostic algorithm for patients with pleomorphic adenoma. Ultrasound-guided FNAB is simple, accurate and valuable in the diagnosis of plemorphic adenoma and provides results that can lead to the choice of less invasive operative treatment. For smaller tumours in favourable locations, extracapsular dissection is a safe and adequate surgical technique with minimal risk to the facial nerve or other local complications and without increased risk of recurrence.