Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):332-341 | DOI: 10.5507/bp.2023.039

The association between preterm births and assisted reproductive technologies

Anna Stastna1, Eva Waldaufova1, Tomas Fait1, 2, 3
1 Department of Demography and Geodemography, Faculty of Science, Charles University, Prague, Czechia
2 Department of Obstetrics and Gynaecology, Second Faculty of Medicine, Charles University, Prague, Czechia
3 Department of Health Care Studies, College of Polytechnics Jihlava, Jihlava, Czechia

Aims: The aim of this study is to determine whether the risk of preterm births differs according to the conception method: with or without ART and according to the ART method used (in-vitro fertilisation (IVF) with fresh embryo transfer, frozen embryo transfer (FET) and oocyte receipt (OoR)).

Methods: The research is based on individualised anonymised data on deliveries in Czechia in 2013-2018 (n=651,049) obtained from the National Health Information System. We employ the survival analysis approach applying survival functions (Life tables method) and Cox regression to model the risk of preterm births according to the conception method when controlling for a set of covariates.

Results: The results revealed that the risk of preterm births in singleton pregnancies is higher for ART-treated women (1.56 to 2.06 depending on the ART method) than for non-ART-treated women. The proportion of preterm births differs according to the ART method; the highest proportion was observed for OoR mothers.

Conclusions: Overall, the differences between ART-treated mothers according to the conception method are due mainly to the structural differences between mothers. When controlling for the covariates (Cox regression model), no significant differences were observed concerning the risk of preterm births for women who underwent fresh IVF, FET and OoR.

Keywords: preterm birth, assisted reproduction technology, in-vitro fertilisation, frozen embryo transfer, oocyte donation

Received: June 30, 2023; Revised: August 30, 2023; Accepted: September 20, 2023; Prepublished online: October 3, 2023; Published: November 22, 2024  Show citation

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Stastna, A., Waldaufova, E., & Fait, T. (2024). The association between preterm births and assisted reproductive technologies. Biomedical papers, 168(4), 332-341. doi: 10.5507/bp.2023.039
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    References

    1. Adamson GD, De Mouzon J, Chambers, Zegers-Hochschild F, Mansour R, Ishihara O, Banker M, Dyer S. International Committee for Monitoring Assisted Reproductive Technology: World Report on Assisted Reproductive Technology, 2015 (preliminary) [online]. Available from: https://secureservercdn.net/198.71.233.206/3nz.654.myftpupload.com/ wp-content/uploads/ICMART-ESHRE-WR2015-FINAL-20200901.pdf.
    2. Lv H, Diao F, Du J, Chen T, Meng Q, Ling X, Li H, Song C, Xi Q, Jiang Y, Xu Y, Tao S, Huang L, Wen M, Peng M, Liu C, Lu Q, He Y, Yin Y, Liu X, Xu B, Han X, Zhou K, Jiang T, Zhao Y, Ma H, G Jin, Xia Y, Liu J, Lin Y, Hu Z, Shen H. Assisted reproductive technology and birth defects in a Chinese birth cohort study. Lancet Reg Health West Pac 2021;7:1-9. doi: 10.1016/j.lanwpc.2020.100090 Go to original source... Go to PubMed...
    3. Kocourková J, Šťastná, A, Burcin B. The influence of the increasing use of assisted reproduction technologies on the recent growth in fertility in Czechia. Sci Rep 2023;13(1):10854. doi: 10.1038/s41598-023-37071-7 Go to original source... Go to PubMed...
    4. Goisis A, Håberg SE, Hanevik HI, Magnus MCh, Kravdal Ø. The demographics of assisted reproductive technology births in a Nordic country. Hum Reprod 2020;35(6):1441-50. doi: 10.1093/humrep/deaa055 Go to original source... Go to PubMed...
    5. Barbuscia A, Myrskylä M, Goisis A. The psychosocial health of children born after medically assisted reproduction: evidence from the UK Millennium Cohort Study. SSM Popul Health 2019;7:100355. doi: 10.1016/j.ssmph.2019.100355 Go to original source... Go to PubMed...
    6. Goisis A, Remes H, Martikainen P, Klemetti R, Myrskylä M. Medically assisted reproduction and birth outcomes: a within-family analysis using Finnish population registers. Lancet 2019;393(10177):1225-32. doi: 10.1016/S0140-6736(18)31863-4 Go to original source... Go to PubMed...
    7. Waldaufová E, Šťastná A. Role reprodukčního stárnutí v nárůstu porodů císařským řezem v Česku. Demografie 2022;64(2):91-105. (In Czech) Go to original source...
    8. Fait T, Šťastná A, Kocourková J, Waldaufová E, Šídlo L, Kníže M. Has the cesarean epidemic in Czechia been reversed despite fertility postponement? BMC Pregnancy Childbirth 2022;22(1):469. doi: 10.1186/s12884-022-04781-1 Go to original source... Go to PubMed...
    9. Waldaufová E, Šťastná A, Fait T. The low birth weights of newborns conceived using assisted reproduction technology. Bratisl Lek Listy 2024;125(2):137-43. doi: 10.4149/BLL_2024_023 Go to original source... Go to PubMed...
    10. Řežábek K. Asistovaná reprodukce. 3. aktualizované a doplněné vydání. Praha: Maxdorf. Farmakoterapie pro praxi 2018. (In Czech)
    11. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2012;98(2):368-77. doi: 10.1016/j.fertnstert.2012.05.019 Go to original source... Go to PubMed...
    12. Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 2014;101(1):128-33. doi: 10.1016/j.fertnstert.2013.09.025 Go to original source... Go to PubMed...
    13. Blencowe H, Cousens S, Oestergaard M, Chou D, Moller A, Narwal R, Adler A, Garcia CV, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 2012:9;379(9832):2162-72. Go to original source... Go to PubMed...
    14. Flood K, Malone FD. Prevention of preterm birth. Seminars in Fetal and Neonatal Med 2012;17(1):58-63. Go to original source... Go to PubMed...
    15. Blickstein I. Does assisted reproduction technology, per se, increase the risk of preterm birth? BJOG: Int J Obstet Gynaecol 2006;113:68-71. Go to original source... Go to PubMed...
    16. ÚZIS ČR 2021. Asistovaná reprodukce v ČR 2018-2019. Praha. ÚZIS ČR. Available from: https://www.uzis.cz/res/f/008365/asistreprodukce2018-2019.pdf (In Czech)
    17. Howson CP, Kinney MV, Lawn JE. March of Dimes, PMNCH, Save the children, WHO. Born too soon: the global action report on preterm birth. Geneva: World Health Organization 2012. Available from: http://www.who.int/pmnch/media/news/2012/201204_borntoosoon-report.pdf
    18. ÚZIS ČR. Rodička a novorozenec 2016-2021. Ústav zdravotnických informací a statistiky, 2023. Available from: https://www.uzis.cz/res/f/008423/rodnov2016-2021.pdf (In Czech)
    19. Tekle FB, Vermunt JK. Event history analysis. In: Cooper H, Camic PM, Long DL, Panter AT, Rindkopf KJ (eds). APA handbook of research methods in psychology. 3rd ed. Washington, DC, US: American Psychological Association 2012:267-90. Available from: https://jeroenvermunt.nl/tekle2010.pdf Go to original source...
    20. Reisnerová, S. Analýza přežití a Coxův model pro diskretní čas. Robust 2004;13:339-46. (In Czech)
    21. ČSÚ 2021. Vývoj obyvatelstva České republiky 2020. Praha: ČSÚ. Available from: https://www.czso.cz/csu/czso/vyvoj-obyvatelstva-ceske-republiky-2020 (In Czech)
    22. Lawn JE, Gravett MG, Nunes TM, Rubens CE, Stanton C, GAPPS Review Group. Global report on preterm birth and stillbirth (1 of 7): definitions, description of the burden and opportunities to improve data. BMC Pregnancy Childbirth 2010;10(1):1-22. doi: 10.1186/1471-2393-10-S1-S1 Go to original source... Go to PubMed...
    23. Giouleka S, Tsakiridis I, Kostakis N, Koutsouki G, Kalogiannidis I, Mamopoulos A, Athanasiadis A, Dagklis T. Preterm Labor: A Comprehensive Review of Guidelines on Diagnosis, Management, Prediction and Prevention. Obstet Gynecol Surv 2022;77(5):302-17. doi: 10.1097/OGX.0000000000001023 Go to original source... Go to PubMed...
    24. Zhao J, Xu B, Zhang Q, Li YP. Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET? a systematic review and meta-analysis. Reprod Biol Endocrinol 2016;14:1-7. Go to original source... Go to PubMed...
    25. Mascarenhas M, Sunkara SK, Antonisamy B, Kamath MS. Higher risk of preterm birth and low birth weight following oocyte donation: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2017;218:60-7. Go to original source... Go to PubMed...
    26. Storgaard M, Loft A, Bergh C, Wennerholm UB, Söderström-Anttila V, Romundstad LB, Aittomaki K, Oldereid N, Forman N, Pinborg A. Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis. BJOG 2017;124(4):561-72. Go to original source... Go to PubMed...
    27. Dudášová J, Šimjak P, Koucký M, Pařízek A. Současné možnosti predikce předčasného porodu. Ceska Gynekol 2019;84(5):355-60. (In Czech)
    28. Koucký M, Malíčková K, Hrdý J, Černý A, Hrbáčková H, Šimják P, Pařízek A. Úloha mateřské imunity a mikrobiomu ženy v patogenezi předčasného porodu. Ceska Gynekol 2017;82(5):407-10. (In Czech)
    29. Řežábek K. Trendy v asistované reprodukci v datech Národního registru asistované reprodukce České republiky v letech 2007-2017. Ceska Gynekol 2020;85(1):4-10. (In Czech)
    30. Volejníková A, Kocourková J. Asistovaná reprodukce v Česku z pohledu přeshraniční reprodukční péče. Demografie 2022;64(2):159-74. (In Czech) Go to original source...
    31. Glujovsky D, Pesce R, Sueldo C, Retamar AMQ, Hart RJ, Ciapponi. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev 2010;(1):CD006359. doi: 10.1002/14651858.CD006359.pub2. Update in: Cochrane Database Syst Rev 2020;10:CD006359. Go to original source... Go to PubMed...
    32. Shennan A, Story L, Jacobsson B, Grobman WA; FIGO Working Group for Preterm Birth. FIGO good practice recommendations on cervical cerclage for prevention of preterm birth. Int J Gynaecol Obstet 2021;155(1):19-22. Go to original source... Go to PubMed...

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