Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024, 168(4):354-358 | DOI: 10.5507/bp.2023.014

Postcovid Guillain-Barré syndrome with severe course - case series two patients including clinical evaluation of smell and examination of olfactory event-related potentials (OERPs)

Nikola Pastorkova1#, Karla Janouskova2, 3, Libor Vasina1, Helene Schulz3, Jaromir Astl2, 3, Richard Holy2
1 Department of Neurology, Military University Hospital, Prague, Czech Republic
2 Department of Otorhinolaryngology and Maxillofacial Surgery, Military University Hospital, Prague, Czech Republic
3 Third Faculty of Medicine, Charles University, Prague, Czech Republic

Introduction: We report a case series two patients of Guillain-Barré syndrome (GBS) associated with previous COVID-19 that both patients survived. GBS is an immune-mediated disease that affects peripheral nerves and can cause life-threatening complications.

Case Reports: In both cases (53-year-old female and 59-year-old male) with severe GBS with complications, the smell of sense was investigated subjectively using Sniffin' sticks identification tests and objectively using objective olfactometry by the evaluation of olfactory event-related potentials (OERPs). Both patients had good results of the subjective Sniffin' sticks identification test without patholgical findings. Results of objective examination of OERPs: the P2-N1 wave complex was equipotent. No olfactory disturbance could be detected in either case, OERPs were plentiful in both cases.

Conclusion: The presentation of a case series two patients of post-covid GBS are an example of one of the many complications of COVID-19 that can cause prolonged recovery. Despite the severe course of GBS and the long recovery time, both patients returned to normal life. An expanded prospective study is planned for the future to investigate post-covid olfactory impairment. The prevalence of GBS associated with COVID-19 is still unknown but it is evident that both mild and severe forms of GBS have been described in patients.

Keywords: Guillain-Barré syndrome, COVID-19 infection, Sniffin stick tests, olfactory event-related potentials, objective olfactometry

Received: March 24, 2023; Revised: April 19, 2023; Accepted: April 21, 2023; Prepublished online: April 27, 2023; Published: November 22, 2024  Show citation

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Pastorkova, N., Janouskova, K., Vasina, L., Schulz, H., Astl, J., & Holy, R. (2024). Postcovid Guillain-Barré syndrome with severe course - case series two patients including clinical evaluation of smell and examination of olfactory event-related potentials (OERPs). Biomedical papers, 168(4), 354-358. doi: 10.5507/bp.2023.014
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