Biomedical papers, 2014 (vol. 158), issue 1
From editor desk
Jitka Ulrichova, Vilim Simanek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1)
Review articles
Effects of β-glucan on some environmental toxins: An overview
Vaclav Vetvicka
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):001-004 | DOI: 10.5507/bp.2013.090
The well-know immune stimulator β-glucan, can have a less-known function - it can protect against the adverse effects of various environmental toxins including mercury, depleted uranium, mycotoxins and aflatoxins. This review represents a state-of-the-art review of the antitoxic effects of β-glucan.
The effect of nano-scale topography on osteogenic differentiation of mesenchymal stem cells
Faezeh Faghihi, Mohamadreza Baghaban Eslaminejad
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):005-016 | DOI: 10.5507/bp.2013.013
This article evaluates the effect of topography, as one of the remarkable characteristics of substrate, on induction and promotion of the signaling pathways involved in osteogenic differentiation of MSCs.
Autoimmune pancreatitis
Petr Dite, Hana Nechutova, Magdalena Uvirova, Jana Dvorackova, Bohuslav Kianicka, Arnost Martinek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):017-022 | DOI: 10.5507/bp.2013.094
This review summarizes recent knowledge about autoimmune pancreatitis as a unique clinical entity within putative IgG4 diseases.
Adrenal disease: a clinical update and overview of imaging. A review
Filip Ctvrtlik, Pavel Koranda, Tomas Tichy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):023-034 | DOI: 10.5507/bp.2014.010
This article provides an overview of the most frequent clinically significant adrenal diseases and to describe the latest trends in their diagnostics, particularly by means of imaging techniques.
Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review
Peter Stanko, Lydie Izakovicova Holla
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):035-038 | DOI: 10.5507/bp.2014.005
Diabetes mellitus increases the risk for and severity of marginal periodontitis and conversely periodontal treatment improves glycemic control in patients with type 2 diabetes.
Original contributions
Valproate activates ERK signaling pathway in primary human hepatocytes
Michal Bitman, Radim Vrzal, Zdenek Dvorak, Petr Pavek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):039-043 | DOI: 10.5507/bp.2012.038
Valproic acid (VPA) is a widely-used anticonvulsant, which also inhibits histone deacetylases (HDACs), enzymes that affect the expression of numerous genes. VPA activates the extracellular signal-related kinase (ERK, p42/p44) pathway (Ras-Raf-MEK-ERK) belonging to the mitogen-activated protein kinase (MAPKs) pathways in primary human hepatocytes.
Investigation of tumour supressor protein p53 in renal cell carcinoma patients
Ingrid Hodorova, Peter Solar, Jozef Mihalik, Janka Vecanova, Marian Adamkov, Silvia Rybarova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):044-049 | DOI: 10.5507/bp.2012.035
Our data demonstrate that p53 might play an important role in this tumour development or progression and it might be used as a new predictor and therapeutic target for renal cell carcinoma.
Histologic evaluation of AlphaCor keratoprosthesis explanted following various complications
Nada Jiraskova, Liliana Werner, Nick Mamalis, Pavel Rozsival
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):050-055 | DOI: 10.5507/bp.2012.040
Histologic findings in two AlphaCor explanted following different complications confirm adequate biointegration of the artificial corneas. Epithelial in growth and scattered chronic mononuclear inflammatory cells were observed in the area of partial extrusion
Array-based karyotyping in chronic lymphocytic leukemia (CLL) detects new unbalanced abnormalities that escape conventional cytogenetics and CLL FISH panel
Helena Urbankova, Tomas Papajik, Radek Plachy, Milena Holzerova, Jana Balcarkova, Martina Divoka, Vit Prochazka, Zuzana Pikalova, Karel Indrak, Marie Jarosova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):056-064 | DOI: 10.5507/bp.2012.031
This article focuses on the contribution of the arrayCGH technique to detection of copy number aberrations in chronic lymphocytic leukemia
Vancomycin pharmacokinetics during high-volume continuous venovenous hemofiltration in critically ill septic patients
Nadezda Petejova, Arnost Martinek, Jana Zahalkova, Jana Duricova, Hana Brozmannova, Karel Urbanek, Milan Grundmann, Jiri Plasek, Ivana Kacirova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):065-072 | DOI: 10.5507/bp.2012.092
Acute kidney injury (AKI) is a common complication in patients with critical conditions like sepsis. Dosing of antibacterial agents in critically ill septic patients is complicated by altered pharmacokinetics due to both AKI and critical illness. Changes in pharmacokinetics, suitable therapeutic drug monitoring and possible dosing regimens for administrating vancomycin to septic patients with AKI on high-volume continuous venovenous hemofiltration at a filtration rate 45 mL/kg b.w./h are presented.
Effect of progesterone-carbachol derivative on perfusion pressure and coronary resistance in isolated rat heart: via activation of the M2 muscarinic receptor
Lauro Figueroa-Valverde, Francisco Diaz-Cedillo, Elodia Garcia-Cervera, Eduardo Pool Gomez, Maria Lopez-Ramos
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):073-079 | DOI: 10.5507/bp.2012.010
The mechanism of the activity exerted by a progesterone-carbachol derivative is described.
Per3 VNTR polymorphism and chronic heart failure
Jolana Lipkova, Julie Anna Bienertova-Vasku, Lenka Spinarova, Petr Bienert, Marian Hlavna, Monika Pavkova Goldbergova, Jiri Parenica, Jindrich Spinar, Anna Vasku
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):080-083 | DOI: 10.5507/bp.2012.069
This study focuses on the effect of genetic variability in circadian genes (Period3) as a potential risk factor for chronic heart failure or factor modulating severity of heart failure.
Arrhythmias and ECG changes in life threatening hyperkalemia in older patients treated by potassium sparing drugs
Marie Berkova, Zdenek Berka, Eva Topinkova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):084-091 | DOI: 10.5507/bp.2012.087
The combination of decrease in functional capacities, polymorbidity and polypharmacy in old people can cause life threatening electrolyte imbalance with fatal rhythm disturbance and terminal heart arrest. The article points out the often overlooked risk of hyperkalemia in elderly people treated by renin-angiotensin-aldosterone system influencing pharmacotherapy and proposes a solution to critical situations.
The variable clinical course of peripartum cardiomyopathy
Jan Krejci, Petr Hude, Lenka Spinarova, Vita Zampachova, Alzbeta Sirotkova, Tomas Freiberger, Eva Nemcova, Jiri Vitovec
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):092-097 | DOI: 10.5507/bp.2012.080
The article deals with peripartum cardiomyopathy, a relatively rare disease, which is very likely in our region underdiagnosed. Increased awareness of the disease should contribute to its detection. The authors describe their own experience with the diverse clinical course of the disease. When properly diagnosed and treated it has a very good prognosis, and vice versa unrecognized or improperly treated can have fatal consequences.
Exercise training combined with electromyostimulation in the rehabilitation of patients with chronic heart failure: A randomized trial
Vladimir Soska, Petr Dobsak, Michal Pohanka, Lenka Spinarova, Jiri Vitovec, Jan Krejci, Petr Hude, Pavel Homolka, Marie Novakova, Jean-Christophe Eicher, Jean-Eric Wolf, Ladislav Dusek, Jarmila Siegelova
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):098-106 | DOI: 10.5507/bp.2012.096
Training protocol based on neuromuscular electrical stimulation of leg muscles combined with standard type of exercise bicycle training, demonstrates significant beneficial effects on physical performance and quality of life in patients with moderate grade of chronic heart failure.
Quantification of pleural effusion on CT by simple measurement
Martin Hazlinger, Filip Ctvrtlik, Katerina Langova, Miroslav Herman
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):107-111 | DOI: 10.5507/bp.2012.042
A simple method of pleural effusion volume quantification based on a single planar measurement on CT scan is devised. The described method is widely applicable in adult patients with free pleural effusion, easy to perform and appropriately accurate.
Comparison of a low-glycemic index vs standard diabetic diet
Jakub Visek, Silvie Lacigova, Daniela Cechurova, Zdenek Rusavy
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):112-116 | DOI: 10.5507/bp.2012.103
This article compares the efficiency of a commonly used diabetic diet and diet with a low glycemic index in patients with type 2 diabetes mellitus.
Severity of periodontal disease in adult patients with diabetes mellitus in relation to the type of diabetes
Alma Pranckeviciene, Jolanta Siudikiene, Rytas Ostrauskas, Vita Machiulskiene
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):117-123 | DOI: 10.5507/bp.2013.098
This study evaluates associations between diabetes mellitus and stages of periodontal disease in adult patients.
Intrathecal synthesis in particular types of multiple sclerosis
Vladimira Sladkova, Jan Mares, Petr Hlustik, Jana Langova, Petr Kanovsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):124-126 | DOI: 10.5507/bp.2012.054
The article discusses the differences in intrathecal synthesis IgG (IgG index) and number of oligoclonal IgG bands in various forms of multiple sclerosis.
A comparison of complication rate between anterior and lateral approaches to the lumbar spine
Lumir Hrabalek, Milan Adamus, Adolf Gryga, Tomas Wanek, Peter Tucek
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):127-132 | DOI: 10.5507/bp.2012.079
This article compares the advantages and disadvantages of both anterior approaches to the lumbar spine, traditional ALIF and new XLIF procedures.
Central facial paresis and its impact on mimicry, psyche and quality of life in patients after stroke
Petr Konecny, Milan Elfmark, Stanislav Horak, Dalibor Pastucha, Alois Krobot, Karel Urbanek, Petr Kanovsky
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):133-137 | DOI: 10.5507/bp.2013.014
Loss of facial expressions is a serious problem in patients after stoke. Targeted orofacial rehabilitation significantly reduces these problems.
Progression of macular atrophy after PDT combined with the COX-2 inhibitor Nabumetone in the treatment of neovascular ARMD
Martin Sin, Oldrich Chrapek, Marta Karhanova, Zuzana Pracharova, Katerina Langova, Jiri Rehak
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):138-143 | DOI: 10.5507/bp.2012.066
A unique clinical study investigating the effects of preferential COX-2 in the treatment of exudative age-related macular degeneration. The results suggest a possible neuroprotective effect of COX-2
Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma
Jan Lestak, Jaroslav Tintera, Zuzana Svata, Lukas Ettler, Pavel Rozsival
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):144-153 | DOI: 10.5507/bp.2013.038
High tension and normal tension glaucoma are regarded worldwide as "one disease". Our study shows the differences between the two diagnostic groups.
Case reports
A complex oncosurgical approach to increasing the resectability of colorectal cancer metastases - a case report
Vladislav Treska, Jarmil Safranek, Daniel Lysak, Hynek Mirka, Tomas Skalicky, Frantisek Slauf, Ondrej Hes
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):154-157 | DOI: 10.5507/bp.2012.005
Hematopoietic stem cells in combination with portal vein embolization provides new insight into the solution of primary unresectable colorectal liver metastases. The authors present a case report describing successful use of a novel method.
Merkel cell carcinoma. Case report
Richard Pink, Martin Molitor, Jiri Ehrmann, Peter Tvrdy, Petr Michl, Jindrich Pazdera
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):158-160 | DOI: 10.5507/bp.2012.034
Merkel cell carcinoma (MCC) is a rare aggressive skin tumour affecting mainly older and immune- suppressed individuals. This case report describes the first experience with Merkel cell carcinoma in an elderly woman on chemo therapy for lymphoma: It covers the diagnosis, treatment and outcome.