Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):080-083 | DOI: 10.5507/bp.2012.069

Per3 VNTR polymorphism and chronic heart failure

Jolana Lipkovaa, Julie Anna Bienertova-Vaskua, Lenka Spinarovab, Petr Bienerta, Marian Hlavnaa, Monika Pavkova Goldbergovaa, Jiri Parenicac, Jindrich Spinarc, Anna Vaskua
a Institute of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic
b 1st Department of Internal Medicine - Cardioangiology, Faculty of Medicine and St. Anne's University Hospital, Brno
c 1st Department of Cardiology, Faculty Hospital Brno

Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF).

Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.

Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found.

Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.

Keywords: circadian clock, Per3, polymorphism, case-control study, chronic heart failure

Received: November 4, 2011; Accepted: July 4, 2012; Prepublished online: October 30, 2012; Published: April 1, 2014  Show citation

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Lipkova, J., Bienertova-Vasku, J.A., Spinarova, L., Bienert, P., Hlavna, M., Pavkova Goldbergova, M., ... Vasku, A. (2014). Per3 VNTR polymorphism and chronic heart failure. Biomedical papers, 158(1), 080-083. doi: 10.5507/bp.2012.069
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