Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(1):112-116 | DOI: 10.5507/bp.2012.103
Comparison of a low-glycemic index vs standard diabetic diet
- a Department of Gerontology and Metabolism, University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
- b Diabetologic Centre, Department of Internal Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen
Aim: There is insufficient evidence for the efficacy of a low-glycemic index (GI) diet in the management of diabetes. The goal of this study was to measure the effect of a low GI versus a standard diabetic diet in adults with diabetes type 2.
Methods: This was an open label, randomized, crossover study. Twenty persons with type 2 diabetes were randomized to two groups. Each group followed a standard diabetic diet or a low glycemic index diet for 3 months. The effectiveness of the two diets was evaluated using a hyperinsulinemic euglycemic clamp with endogenous glucose production measurement, indirect calorimetry and bioimpedance analysis. Outcome measures were body mass, BMI, body fat, glycosylated hemoglobin, fasting glucose, lipid profile, insulin sensitivity and hepatic glucose production.
Results: Body mass after 3 months following the diabetic diet was 93 kg (83-104) vs. low glycemic index diet 92 kg (85-104) P<0.05, BMI 31.3 kg/m2 (27.5-35.9) vs. 30.7 kg/m2 (27-35.3) P<0.05, body fat 28% (25.5-43) vs. 27% (23-43) P<0.05 (median and interquartile range). There was no statistically significant difference between diets for glycosylated hemoglobin, fasting glucose, lipid profile, insulin sensitivity or hepatic glucose production.
Conclusions: The results are comparable with other studies showing a modest effect of a low GI diet in the management of diabetes. We found a modestly greater weight loss, body fat and BMI reduction on the low GI diet.
Keywords: diabetes type 2, low glycemic index diet, standard diabetic diet, hepatic glucose production
Received: December 10, 2011; Accepted: November 13, 2012; Prepublished online: December 7, 2012; Published: April 1, 2014 Show citation
References
- American Diabetes Association. Nutrition Principles and Recommendations in Diabetes. Diabetes Care 2008; 31:61-78.
Go to original source...
Go to PubMed...
- Jenkins DJA, Wolever TMS, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV. Glycemic index of foods: a physiological basis for carbohydrate exchange. American Journal of Clinical Nutrition 1981; 34:362-6.
Go to original source...
Go to PubMed...
- Wolever TMS, Jenkins DJA, Jenkins AL, Josse RG. The glycemic index: metodology and clinical implications. Am J Clin Nutr 1991;54:846-54.
Go to original source...
Go to PubMed...
- Visek J, Zourek M, Lacigova S, Rusavy Z. Influence of fiber on glycemic index of enteral nutrition. JPEN 2007;31:491-5.
Go to original source...
Go to PubMed...
- Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low-Glycemic Index Diets in the Management of Diabetes. Diabetes Care 2003;26:2261-8.
Go to original source...
Go to PubMed...
- McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PWF, Jacques PF. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care 2004; 27:538-46.
Go to original source...
Go to PubMed...
- Levitan EB, Cook NR, Stampfer MJ, Ridker PM, Rexrode KM, Buring JE, Manson JE, Liu S. Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. Metabolism 2008;57(3):437-43.
Go to original source...
Go to PubMed...
- Rusavy Z, Sramek V, Lacigova S, Novak I, Tesinsky P, Macdonald IA. Influence of insulin on glucose metabolism and energy expenditure in septic patients. Critical Care 2004;8(4):213-20.
Go to original source...
Go to PubMed...
- Steele R. Influences of glucose loading and injected insulin on hepatic glucose output. Ann NY Acad Sci 1959;82:420-30.
Go to original source...
Go to PubMed...
- American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35:11-63.
Go to original source...
Go to PubMed...
- Foster-Powell K, Holt SHA,, Brand-Miller JC. International table of glycemic index and glycemic load values. Am J Clin Nutr 2002;76:5-56.
Go to original source...
Go to PubMed...
- Brand Miller J, Leeds A, Foster-Powell K, Colagiuri S. The GI Factor. Australia, Hodder Headline PLC, 1996.
- Ludwig DS. The glycemic index. Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 2002;287(18):2414-23.
Go to original source...
Go to PubMed...
- DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318-68.
Go to original source...
Go to PubMed...
- Monnier L, Lapinsik H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA1c. Diabetes Care 2003;26:881-5.
Go to original source...
Go to PubMed...