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Repair of inguinal hernia represents one of the most frequent general surgical operations in newborns, infants, and toddlers. Injury to the vas deferens (VD) during herniotomy is one of the most common complications in 0.8-2.0 % of cases. The aim of this study was to evaluate whether the different vasovasostomy techniques can be performed using only the operating loupe in a rat model. This operating method is predicted to be applicable in standard departments of pediatric surgery.

The authors present a study comparing the strategy of early and standard discharge in selected patients after myocardial infarction with ST-segment elevation (STEMI). The results show the possibility and safety of a length of hospital stay of 48-72 h and further support the recently released new version of ESC guidelines for STEMI in terms of the level of evidence for the strategy with the shorter recommended length of hospital stay.

The HOMA1-IR index is the most frequently proposed indirect index of insulin resistance assessment in clinical and laboratory practice, and its use is also widespread in epidemiological studies. There is a justified need to set reference intervals for indirect insulin resistance indicators for particular populations, ethnic groups, etc. in order to reliably diagnose insulin resistance and increase metabolic disease prevention. When defining reference intervals, various limitations should be taken into account, primarily analytical and pre-analytical ones and differences between populations.

This study examines the clinical utility of magnetic resonance imaging as part of diagnostic procedures on autism. The key finding of the study was that corpus callosum hypoplasia was significantly more common in the autistic compared to the control group (13.7 vs. 0%), and it appears to be the rather specific finding, which should raise suspicion of autism.

Congenital heart defects represent the most frequent congenital defects in the human population, while one third of these cases are associated with further genetic or extra-cardiac morphological anomalies. This association must be carefully taken into consideration in the prenatal counselling.

This study relates to the current topic of imaging methods in supporting ablation of atrial fibrillation. From the literature, no prior study has compared the clinical outcomes of ablation procedures using 3D rotational angiography as a substitute for cardiac CT. The clinical results of this study demonstrate the utility of 3D rotation angiography as an adequate alternative to a commonly performed CT scan.

This paper describe a patient with a rare chromosomal aberration - a pure de novo subtelomeric 17p13.2-pter duplication. Despite known facial features, the proband presented with oculocutaneous albinism which has not been reported previously. The authors discuss in detail the genotype-phenotype correlations of the aberration as well as the possible molecular etiology of albinism apropos the mode of inheritance.

This paper describes research based on quantum dots between human amniotic membrane mesenchymal stem cells. The observed compatibility of the two and the changes in cell growth, provide a new approach to cell markers

Two sides of the miRNA29 family. Are they suppressors or promoters in hematooncology?

The text presents comprehensive information concerning the issue of out-of-hospital cardiac arrest. The text is summarizing current knowledge of epidemiology of the OHCA and describing the mechanisms of loss of effective circulation. The attention is paid to the circumstances of circulation arrest as well as to relationship between first recorded rhythm and clinical patient outcome. The paper is based particularly on synthesis of large registers' results, dealing with patients resuscitated outside of the hospital environment.

This case report describes an interesting case of overt hyperthyroidism in a thyroidectomised patient. It illustrates the clinical search for functional ectopic thyroid tissue utilizing a multidisciplinary clinical approach.

This study showed that patients with premature manifestation of coronary artery disease had significantly lower Omentin-1 serum levels than patients with metabolic syndrome and healthy subjects. To the best of their knowledge, the authors report that this is the first study to assess omentin-1 levels in younger patients with premature manifestations of atherosclerosis. Serum omentin-1 appears to be a useful biomarker of coronary artery disease across the whole age spectrum.

This is the first prospective study that compares the results (neurological deterioration, overall survival time) of resection and biopsy of glioblastoma (GBM) in eloquent brain areas (EBA). For patients in good clinical condition and for tumors in or near EBA, resection of the GBM (as radical as possible) is recommended.

This paper summarises recent evidence on of the structure and functions of tissue factor. It covers the role of tissue factor and its inhibitor in blood coagulation, the inflammatory response, angiogenesis and cell migration. The paper is specifically aimed at the role of tissue factor in the uteroplacental vessel network during physiological pregnancy and pregnancy complicated by preeclampsia

Vulnerable atherosclerotic plaque is currently a highly debated topic in cardiology, particularly in the field of coronary and carotid interventions. The aim of this article is to provide a comprehensive overview of the most up-to-date information on this topic with a focus on advanced imaging.

Methylation of tumor suppressor genes in sinonasal carcinoma is an important event and it has the potential to serve as a prognostic biomarker.

Based on a literature search, we identified three features of the retina that appear to show characteristic changes in schizophrenia - microvasculature, electroretinogram and optical coherence tomography. These novel findings may serve as biomarkers and help to address the diagnostic, predictive, preventative, prophylactic and therapeutic aspects of schizophrenia.

Hemodiafiltration may be considered a risk factor for underdosing and the drug dosage of axitinib should be monitored and if needed also corrected, based on the actual plasma levels.

The search for and research of new compounds with antimicrobial properties is mandatory in the current situation of worldwide bacterial resistance. Hops (Humulus lupulus L.) constituents and metabolites have been determined to act as anti-infective agents. The authors tested the antimicrobial properties of hop components humulone, lupulone and xanthohumol against reference and resistant bacterial strains such as VRE and MRSA. Hop substances had antimicrobial effects against tested Gram-positive bacteria and these effects were displayed even at concentrations well below those of determined MICs.

Mucosal administration systems offer an alternative to the oral route when the latter is not tolerated, contraindicated or refused. Perindopril arginine and Amlodipine besylate are registered in the EU in the form of orodispersible tablets for mucosal delivery, however, they are not available in all countries. Antihypertensive drugs Captopril and Nitrendipine administered sublingually are commonly used in hypertensive urgencies. Metoprolol tartrate suppositories have only been tested in pharmacokinetic studies in humans. Propranolol suppositories have been reported clinically in a case report. Furosemide suppositories have been tested in animals, but there are no reports of their use in humans. New insights into a practical approach: a) First use of Furosemide-containing suppositories in a human subject. b) A successful regimen of four different antihypertensive drugs administered long-term via the mucosal route (rectal Furosemide and Metoprolol tartrate combined with sublingual Captopril and Nitrendipine).

The significance of the paper is in the fact that it includes the most relevant and the latest information on this very common functional syndrome. The aim of the authors is to provide both comprehensive and concise data which will be of value to doctors whose clinical practice brings them into contact with patients with the clinical picture of this syndrome.

Common recorded data in polygraphic monitoring systems can help in the prediction of CPAP failure. The main risk factors for CPAP failure are BMI and T90.

Arterial blood lactate levels were regularly monitored in 51 newborns who were undergoing therapeutic hypothermia for neonatal asphyxia. The results show that persistently high levels of lactate in the early stages of treatment for hypoxic ischaemic encephalopathy are an indicator of possible adverse psychomotor development at 2 years of age.

This review covers the role of Nrf2 and NF-κB during the skin restoration process and evaluates whether they can be used as markers.

The presence of gasping at the time of EMS arrival on the scene is associated with improved chance of return of spontaneous circulation and six-month survival. The latter is a new finding. EMS dispatchers and the EMS ambulance teams should recognize and understand this phenomenon as it can have impact on medical care provided to OHCA patients.

This article provides an updated overview of the structural and functional changes in normotensive glaucoma and its divergence from hypertensive glaucoma. The authors point out the less familiar facts in which the diagnostic groups differ.

Clinical monitoring during volatile anesthesia provides adequate protection during surgery. However, during intravenous anesthesia, the observation of clinical parameters is insufficient for stable maintenance of anesthesia and does not prevent intraoperative awareness. Clinical monitoring itself does not exclude periods of too deep anesthesia. The AAI index is a useful tool in monitoring patients' level of conscience during anesthesia.

The authors found that the diaphragm is present in the region of conventional lung monitoring using electrical impedance tomography. During capnoperitoneum, the thoraco-abdominal configuration changes with confounding effects of the diaphragm on the EIT image. This may reduce the use of this method during laparoscopic surgeries. For this reason, the authors assume that for lung monitoring using EIT during capnoperitoneum, the manufacturer's recommendation of electrode belt position are unsuitable.

This article provides new data on related autoimmune comorbidities and thyroid carcinoma in autoimmune thyreopathies in a large group of children and adolescents in the Czech Republic.

The optimal treatment for paroxysmal hypertension or pseudopheochromocytoma has not been established. We added sertraline, 50 mg once daily, to the current medication of 64 patients with symptomatic paroxysmal hypertension. Within 3 months of treatment, sertraline effectively removed or reduced symptoms of paroxysmal hypertension in the majority (75%) of patients. Symptoms of paroxysmal hypertension fully subsided in 50% and were partially reduced in 25% of patients.