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Study of the tear and ocular tissue metabolome may help us understand the metabolism of normal ocular tissues and mechanisms in disease, to discover inter-individual variations within the ocular environment and, thus improve diagnosis and prognosis. Metabolomic profiling of tear, aqueous humor and vitreous samples is useful for identifying biomarkers for more precise diagnosis, prognosis, and therapy.

This initial experience and preliminary results confirm the safety of the combined treatment modality of CRS/HIPEC although the results are limited by the size and heterogeneity of the cohort. More complications were seen in HIPEC with oxaliplatin in the presented cohort.

This study is the first to collate multicenter data on the epidemiology of HAP in the Central European Region. The patient cohort was divided into early- and late-onset HAP subgroups. A subgroup of patients with VAP was assessed separately. The study focuses on relationships between 30-day patient mortality and type of HAP, etiologic agent and type of antibiotic used for initial empirical therapy. The study reports on the epidemiology in the above region with respect to the incidence of etiologic agents causing HAP and provides an overview of treatment efficacy and adequacy of antibiotic therapy.

The study followed a cohort of patients in the immediate days after stroke to assess the frequency of post-stroke spasticity (PSS) and to identify potential risk factors for PSS development. Better understanding of the evolution of the disorder along with identification of PSS risk factors could lead to earlier treatment and better outcomes. Knowledge of the epidemiology of PSS in Czech Stroke Centers should help with aftercare organization.

In this pilot study, the authors are the first to assess the genetic architecture of recent-onset dilated cardiomyopathy in 83 individuals from the region of Moravia in the Czech Republic by whole-exome sequencing (WES). WES detected at least one disease-related variant in 54% of patients, highlight the genetic origin of the disease. Individuals with disease-related variants of non-titin genes showed impaired left ventricular reverse remodelling, a marker of poor prognosis, at 12-month follow-up compared to individuals with no genetic cause.

The goal was to assess the frequency of paraneoplastic neurological disorders in patients with advanced malignancy. Hypotension may be a symptom of paraneoplastic neuropathy

The authors present a study comparing the strategy of early and standard discharge in selected patients after myocardial infarction with ST-segment elevation (STEMI). The results show the possibility and safety of a length of hospital stay of 48-72 h and further support the recently released new version of ESC guidelines for STEMI in terms of the level of evidence for the strategy with the shorter recommended length of hospital stay.

Quercetin is a widely distributed compound isolated from plants and is one of the most abundant dietary flavonoids. It is able to modulate expression of miRNA, many of which are recognized as oncogenic or tumor suppressor miRNAs. This review is a critical evaluation of recent research on miRNAs modulated by quercetin.

This paper summarises recent evidence on of the structure and functions of tissue factor. It covers the role of tissue factor and its inhibitor in blood coagulation, the inflammatory response, angiogenesis and cell migration. The paper is specifically aimed at the role of tissue factor in the uteroplacental vessel network during physiological pregnancy and pregnancy complicated by preeclampsia

This article describes the use of kinematic analysis of movement in newborns. By determining the center of mass (COM) and its motion in time, neonatal postural activity may be indirectly assessed. Significant differences in certain characteristics of motion of the COM in the group of preterm infants were found.

In about 30-40% of patients undergoing visceral organ transplantation, the abdominal compartment is retracted and to varying degrees direct closure of the abdominal wall is problematic. In some cases, abdominal wall allotransplantation is the only viable option available. This review provides evidence that this procedure is viable and is not followed by any higher risk of complications or rejection of the visceral organs.

The autonomic nevous system can be impaired in the presence of atheroma in the carotid sinus region. The authors assessed the effect of elective unilateral carotid endarterectomy on cardiovascular autonomic functions as a major prognostic factor of cardiovascular health.

Clinical monitoring during volatile anesthesia provides adequate protection during surgery. However, during intravenous anesthesia, the observation of clinical parameters is insufficient for stable maintenance of anesthesia and does not prevent intraoperative awareness. Clinical monitoring itself does not exclude periods of too deep anesthesia. The AAI index is a useful tool in monitoring patients' level of conscience during anesthesia.

There has been much recent attention on tumoral lymphangiogenesis. Relevant information on malignant salivary gland tumors is very limited and virtually non existent on benign forms. The presented paper demonstrates that Warthin´s tumor but not other benign salivary adenomas is rich in stromal lymphatics. This difference is due to lymphoid stroma in the former lesion, producing major lymphangiogenic factors.

Insomnia affects a large percentage of cystic fibrosis patients and reduces the quality of life. Anxiety and depression are factors that increase the risk of insomnia. Steps should be taken to identify predictors of insomnia such as anxiety and depression and implement appropriate remedial measures.

Mucosal administration systems offer an alternative to the oral route when the latter is not tolerated, contraindicated or refused. Perindopril arginine and Amlodipine besylate are registered in the EU in the form of orodispersible tablets for mucosal delivery, however, they are not available in all countries. Antihypertensive drugs Captopril and Nitrendipine administered sublingually are commonly used in hypertensive urgencies. Metoprolol tartrate suppositories have only been tested in pharmacokinetic studies in humans. Propranolol suppositories have been reported clinically in a case report. Furosemide suppositories have been tested in animals, but there are no reports of their use in humans. New insights into a practical approach: a) First use of Furosemide-containing suppositories in a human subject. b) A successful regimen of four different antihypertensive drugs administered long-term via the mucosal route (rectal Furosemide and Metoprolol tartrate combined with sublingual Captopril and Nitrendipine).

Methylation of tumor suppressor genes in sinonasal carcinoma is an important event and it has the potential to serve as a prognostic biomarker.

In the past, supernumerary teeth caused mainly esthetic and sometimes orthodontic problems. Recently, successful allo- and auto-transplantation of these teeth have been reported, but studies on their durability and resistance to tooth decay still do not exist. It is clear that the degree of mineralization is very important factor for the resistance. The goal of this study was to determine the differences in inorganic mineral content in supernumerary and healthy teeth.

This is a review of the outcome analysis of treatment strategies of DSWI which compares modern treatment strategies including negative pressure wound therapy followed by stable sternotomy wound reconstruction, with conventional therapy based on closed irrigation or application of muscle or omental flap after sternotomy wound debridement. Complications and drawbacks of treatment strategies are critically evaluated to outline options on successful management of this feared complication. This is a review of the outcome analysis of treatment strategies of DSWI which compares modern treatment strategies including negative pressure wound therapy followed by stable sternotomy wound reconstruction, with conventional therapy based on closed irrigation or application of muscle or omental flap after sternotomy wound debridement. Complications and drawbacks of treatment strategies are critically evaluated to outline options on successful management of this feared complication.

The review summarizes the current view of the diagnosis of retrocochlear sensorineural hearing loss, the sensitivity of audiological methods in comparison to MRI for diagnosing a CPA mass. The authors conclude that in light of a more conservative treatment approach to CPA tumours, audiological methods are still a valuable alternative to MRI especially in terms of cost-effectiveness in the case of the Czech healthcare system.

The significance of the paper is in the fact that it includes the most relevant and the latest information on this very common functional syndrome. The aim of the authors is to provide both comprehensive and concise data which will be of value to doctors whose clinical practice brings them into contact with patients with the clinical picture of this syndrome.

A survey questionnaire study of neonates with gastroschisis gives unique feedback on their somatic growth and quality of life.

The effectiveness of the WinROP system was tested in a population of 445 prematurely born infants from the Czech Republic. WinROP proved to be a valuable tool as it correctly identified all 24 patients who developed Type 1 or Type 2 ROP requiring or potentially requiring intervention.

This article is about the Scharioth Macula Lens implant which acts as a magnifier in the eye and improves near vision in low vision patients with stabilized maculopathy. The first experience with this intraocular lens is presented.In the experience of the authors, the prospects of reading rehabilitation after SML implantation are promising; despite very severe findings in the macula, the SM and enabled the patients involved to read again and with a better quality of life.

Delirium and brain dysfunction, is frequent complication in critically ill patients. The primary aim of this study was to recognize and explore risk factors of the development delirium to allow prevention. The main risk factors are age, APACHE II score, admission type, alcohol abuse in anamnesis, length of ICU stay, duration of artificial ventilation, need for vasopressors, and the use of drug-induced sedation.

This paper provides evidence supporting the use of the synovial white cell count as well as neutrophil and lymphocyte percentages in the diagnostic workup for prosthetic joint infection.

The authors argue that a significant reproducibility crisis is under way in medical research. Two causes are discussed, perverse incentives and inapropriate statistics, and a way forward is offered.

The aim of this study was to assess the clinical benefit of several parameters measured from CT pulmonary angiography. Their relation to clinical outcome - administration of thrombolytic therapy and to other currently used methods (biomarkers,echocardiography) were studied. The statistical analysis, showed the RV/LV diameter ratio measured from CT images was the most valid parameter.

This study relates to the current topic of imaging methods in supporting ablation of atrial fibrillation. From the literature, no prior study has compared the clinical outcomes of ablation procedures using 3D rotational angiography as a substitute for cardiac CT. The clinical results of this study demonstrate the utility of 3D rotation angiography as an adequate alternative to a commonly performed CT scan.

A number of genes associated with the development and function of synapses play significant roles in autism. This review focuses on deficits in synaptic proteins associated with autism and animal genetic models of autism with respect to alterations in selected synaptic proteins such as neuroligins, neurexins and shank proteins.