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Uterus transplantation appears to be a perspective treatment modality of absolute uterine factor infertility but it is still at an experimental stage worldwide. In this article, observational data on pregnancy outcomes, neonatal course, growth trajectory and 3-year follow-up in two children born at our institution in 2019 to mothers after uterus transplantation were analyzed, including assessment of neurodevelopment using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). No abnormalities were observed in either prematurely born babies in terms of the neonatal course and 3-year follow-up, including the neurodevelopmental status. This is the first ever report on neurodevelopmental outcomes in children born after uterus transplantation.

Predicting sepsis outcomes remains a challenge. In this retrospective study of two separate cohorts, we sought to determine the relationship between BUN levels on admission and 28-day mortality in sepsis. We provide new high-level information for intensivists to adopt blood urea nitrogen (BUN) as an easily available prognostic marker in sepsis.

This case report describes the management of treatment of HCL in a 53-year-old woman who developed a rare lung condition as part of the activity of the hematological disease. The authors present the differential diagnosis of pulmonary disease in patients with HCL and the treatment approach in these patients.

Antiphosphatidylethanolamine antibodies (aPE) may be related to venous thromboembolism and be part of the repertoire of aPL in immunologically-mediated diseases. aPE IgG may have various avidities and their avidities differ from those of anticardiolipin antibodies IgG.

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Visual field defects persist after antibiotic treatment in one third of patients with syphilitic uveitis. The observation supports adjacent systemic corticosteroid treatment for severe forms of syphilitic uveitis and/or neuritis.

Arterial stiffness and aortic stenosis share similar cardiovascular risk factors and they are frequently associated, leading to increased left ventricular afterload. Even though accurate estimation of arterial stiffness in AoS is challenging, the coexistence of an increased pulsatile load may influence patient outcome before as well as after aortic valve replacement.

Over 40 monitoring methods of micro-vascular flaps have been reported in the scientific literature and it is difficult to discern the benefits of these over other methods or over direct visual monitoring, the standard method. In this review, we collated all reported monitoring methods to date and critically assessed their value including for practical use. We found that direct visual monitoring remains the most used, is very reliable and cheapest method for micro-vascular flap assessment. Only Doppler ultrasound, laser Doppler flowmetry and near infrared spectroscopy show any evidence of greater value but they require special equipment, experienced personnel and are more expensive.

Continuous positive airway pressure (CPAP) is the most effective therapy for obstructive sleep apnoea syndrome (OSAS). The aim of this study was to assess the ten-year adherence to CPAP therapy, and to define the factors influencing it. Sufficient adherence, which was defined as more than 4 hours of CPAP use per night, was found in 57% of patients in the first year with no subsequent significant change over the next 9 years. Adherence to therapy correlated significantly with the severity of OSAS and Epworth Sleepiness Scale score but did not correlate with the pressure used or the age of the patient.

These data analyses are the first for cabozantinib-treated patients in the Czech Republic. The evaluation of treatment outcomes and tolerance in an initial group of treated patients with metastatic renal cell carcinoma provides important evidence for informing future treatment decisions.

The authors present a case of paraneoplastic pemphigus expanding the spectrum of known associated internal malignancies describing concomitant tonsillar HPV associated squamous cell carcinoma. The oral presentation of paraneoplastic pemphigus was the first manifestation of this malignancy allowing its early detection by the whole-body 18F-FDG PET/MRI and subsequent successful treatment.

This review opens up new perspectives for the treatment of IBD and CRC. In particular, the use of EVs derived from the intestinal microbiota could represent an innovative, safe and effective therapeutic strategy, as an adjuvant therapy for these pathologies.

This article reviews the role of biomarkers that could be used in the diagnosis and treatment of pelviureteral junction obstruction in children.

The paper gives an overview of current visual neuroprostheses and explains their failures. In the second part it presents a new method based on transcranial stimulation of functional cells of the visual cortex. This technology is protected by a patent.

The first report on serial BNP monitoring in out-patients with a continuous-flow LVAD. BNP changes allow identification of clinical events with the need for further diagnostic and therapeutic interventions.

The optimal treatment for paroxysmal hypertension or pseudopheochromocytoma has not been established. We added sertraline, 50 mg once daily, to the current medication of 64 patients with symptomatic paroxysmal hypertension. Within 3 months of treatment, sertraline effectively removed or reduced symptoms of paroxysmal hypertension in the majority (75%) of patients. Symptoms of paroxysmal hypertension fully subsided in 50% and were partially reduced in 25% of patients.

Recent studies show several non-motor features that may precede the development of the motor symptoms of PD. The best known include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. The aim of this review is to summarize the currently available methods for diagnosing these premotor symptoms of PD which may help in the early diagnosis of PD.

Cardiac sarcoidosis is increasingly recognised as an important cause of life-threatening arrhythmias and heart failure. The aim of this review is to provide readers with current views on the etiopathogenesis, diagnostic and therapeutic options for this condition.

Direct visual monitoring of micro-vascular flaps is still generally and preferentially used. In cases where the flap is not exposed - buried or semi-buried flap, direct visual monitoring is not straightforward. However, apart from a few exceptions, each micro-surgical flap can be designed as a composite which includes a skin island that can serve as a direct monitor of flap viability. This review describes all the published techniques for externalising part of a buried flap. It also defines which tissues are suitable to be used as an externalised component of the flap and summarises the principles that need to be observed to achieve the greatest reliability and validity of the externalised flap's segment monitoring.

COVID-19 can alter adrenal gland function by multiple mechanisms. And also, it is predicted that there may be a critical illness-related change in the pharmacokinetics of glucocorticoids in COVID-19 infection. These effects should be taken into account when using glucocorticoids in COVID-19 patients with or without previously known adrenal insufficiency. In patients with adrenal insufficiency, a more dynamic approach and close follow-up are required for glucocorticoid replacement in patients with COVID-19.

A prospective, randomized, double-blinded and controlled study compared non-leaching central venous catheter (Certofix® protect) with a standard catheter (Certofix®). There was no difference for catheter colonization rates between the coated and uncoated catheter. However, the coated central venous catheter showed a significantly lower incidence of bloodstream infections and a significantly lower mean incidence of bloodstream infections per 1000 catheter days.

The efficacy and safety of riociguat (an oral stimulator of soluble guanylate cyclase) is demonstrated in a randomized clinical trial in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or residual pulmonary hypertension after pulmonary endarterectomy (PEA). The study evaluated the effectiveness and safety of riociguat in a real-world sample of 51 patients with inoperable CTEPH or residual pulmonary hypertension after PEA. The results confirm that riociguat therapy even in a real-world population significantly improves d functional NYHA class, distance in the 6MWD test and quality of life.

Out-of-hospital cardiac arrest is a priority emergency for emergency medical services. The success rate of cardiopulmonary resuscitation is a fundamental parameter of the quality of provided pre-hospital emergency care. The study confirmed that the epidemiology of out-of-hospital cardiac arrest in the Pilsen region corresponds to the data from other studies worldwide. The resulting survival rate with good neurological score was found to be higher than a number of other studies.

The authors report a case of a patient in whom an oral carcinoma developed on the site of a smokers' lesion - an oral white lesion considered completely benign by guidelines - after its full regression. An autofluorescent device VELscope was instrumental in the discovery of the carcinoma.

The results of this study showed significant differences in average values for visual acuity obtained from the two methods used (sVEP and Snellen) in both samples. The authors confirmed significant correlations between repeated sVEP measurements. Objective measurement of visual acuity using sVEP is valid and reliable. They recommend using it only when it is not possible to use a subjective method for measuring visual acuity, e.g. children, mentally retarded or in cases of simulation/dissimulation.

This study is the first to comprehensively describe micronutrient deficits in patients after endoscopic bariatric intervention. In addition, our data show the need for supplementation not only in bariatric surgery patients, but also in patients undergoing bariatric endoscopy.

Mixed-phenotype acute leukemia (MPAL) is a rare disease with a poor prognosis. This review article evaluates the relevant literature and summarizes current knowledge and treatment of MPAL.

The article provides an up-to-date overview of the current awareness of a new type of coronavirus. It is introduced with current information on the course of COVID-19 infections. The authors further offer recommendations on how to proceed with possible modification of immunomodulatory therapy in multiple sclerosis in the light of COVID-19 infection, since it is more difficult for physicians to recommend appropriate therapy if a patient develops COVID-19, especially if the patient is also suffering from another disease that may be exacerbated by a new type of coronavirus.

Chromosomal abnormalities of the melanoma can accurately predict the risk of metastases in affected patients. Testing is routinely carried out in oncology care in the United States and in some European states. These are the first results from the Czech population.

Retroperitoneal tumors are relatively common, the impairment spectrum is broad, and safe establishment of correct diagnosis is crucial for the planning of further therapies. CT-guided biopsy using a percutaneous approach is a suitable interventional method with comparable diagnostic accuracy to surgical excision, but significantly less invasive.