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Uterus transplantation appears to be a perspective treatment modality of absolute uterine factor infertility but it is still at an experimental stage worldwide. In this article, observational data on pregnancy outcomes, neonatal course, growth trajectory and 3-year follow-up in two children born at our institution in 2019 to mothers after uterus transplantation were analyzed, including assessment of neurodevelopment using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). No abnormalities were observed in either prematurely born babies in terms of the neonatal course and 3-year follow-up, including the neurodevelopmental status. This is the first ever report on neurodevelopmental outcomes in children born after uterus transplantation.

Rationalized cost-effective ECG monitoring that properly assesses the outcome of catheter ablation for paroxysmal atrial fibrillation remains challenging. By comparing two modes of episodic ECG monitoring during 12-month post-ablation follow-up, daily discontinuous ECG recording was found to be superior in detecting recurrent atrial fibrillation compared to continuous episodic ECG monitoring applied twice for around 1 week. Entirely asymptomatic patients with recurrent arrhythmias at risk of misinterpretation of ablation outcome and false decision on further anticoagulation management were rare.

In this article, the authors report on IL-8 polymorphisms and their association with periodontitis. Various studies analyse different polymorphisms and their association with periodontitis, but conflicting results regarding the disease relation to IL-8 polymorphisms are being apprised. In this paper, the focus is on the genetic aspect of periodontitis.

Over 40 monitoring methods of micro-vascular flaps have been reported in the scientific literature and it is difficult to discern the benefits of these over other methods or over direct visual monitoring, the standard method. In this review, we collated all reported monitoring methods to date and critically assessed their value including for practical use. We found that direct visual monitoring remains the most used, is very reliable and cheapest method for micro-vascular flap assessment. Only Doppler ultrasound, laser Doppler flowmetry and near infrared spectroscopy show any evidence of greater value but they require special equipment, experienced personnel and are more expensive.

These data analyses are the first for cabozantinib-treated patients in the Czech Republic. The evaluation of treatment outcomes and tolerance in an initial group of treated patients with metastatic renal cell carcinoma provides important evidence for informing future treatment decisions.

This article reviews the role of biomarkers that could be used in the diagnosis and treatment of pelviureteral junction obstruction in children.

The paper gives an overview of current visual neuroprostheses and explains their failures. In the second part it presents a new method based on transcranial stimulation of functional cells of the visual cortex. This technology is protected by a patent.

Arterial stiffness and aortic stenosis share similar cardiovascular risk factors and they are frequently associated, leading to increased left ventricular afterload. Even though accurate estimation of arterial stiffness in AoS is challenging, the coexistence of an increased pulsatile load may influence patient outcome before as well as after aortic valve replacement.

The optimal treatment for paroxysmal hypertension or pseudopheochromocytoma has not been established. We added sertraline, 50 mg once daily, to the current medication of 64 patients with symptomatic paroxysmal hypertension. Within 3 months of treatment, sertraline effectively removed or reduced symptoms of paroxysmal hypertension in the majority (75%) of patients. Symptoms of paroxysmal hypertension fully subsided in 50% and were partially reduced in 25% of patients.

A prospective, randomized, double-blinded and controlled study compared non-leaching central venous catheter (Certofix® protect) with a standard catheter (Certofix®). There was no difference for catheter colonization rates between the coated and uncoated catheter. However, the coated central venous catheter showed a significantly lower incidence of bloodstream infections and a significantly lower mean incidence of bloodstream infections per 1000 catheter days.

Direct visual monitoring of micro-vascular flaps is still generally and preferentially used. In cases where the flap is not exposed - buried or semi-buried flap, direct visual monitoring is not straightforward. However, apart from a few exceptions, each micro-surgical flap can be designed as a composite which includes a skin island that can serve as a direct monitor of flap viability. This review describes all the published techniques for externalising part of a buried flap. It also defines which tissues are suitable to be used as an externalised component of the flap and summarises the principles that need to be observed to achieve the greatest reliability and validity of the externalised flap's segment monitoring.

The authors review lipid changes in pregnancy. The text focuses on pregnancies with gestational diabetes. Gestational dyslipidaemia is thought to be a key driver of foetal outcome.

The efficacy and safety of riociguat (an oral stimulator of soluble guanylate cyclase) is demonstrated in a randomized clinical trial in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or residual pulmonary hypertension after pulmonary endarterectomy (PEA). The study evaluated the effectiveness and safety of riociguat in a real-world sample of 51 patients with inoperable CTEPH or residual pulmonary hypertension after PEA. The results confirm that riociguat therapy even in a real-world population significantly improves d functional NYHA class, distance in the 6MWD test and quality of life.

Out-of-hospital cardiac arrest is a priority emergency for emergency medical services. The success rate of cardiopulmonary resuscitation is a fundamental parameter of the quality of provided pre-hospital emergency care. The study confirmed that the epidemiology of out-of-hospital cardiac arrest in the Pilsen region corresponds to the data from other studies worldwide. The resulting survival rate with good neurological score was found to be higher than a number of other studies.

The results of this study showed significant differences in average values for visual acuity obtained from the two methods used (sVEP and Snellen) in both samples. The authors confirmed significant correlations between repeated sVEP measurements. Objective measurement of visual acuity using sVEP is valid and reliable. They recommend using it only when it is not possible to use a subjective method for measuring visual acuity, e.g. children, mentally retarded or in cases of simulation/dissimulation.

The authors report a case of a patient in whom an oral carcinoma developed on the site of a smokers' lesion - an oral white lesion considered completely benign by guidelines - after its full regression. An autofluorescent device VELscope was instrumental in the discovery of the carcinoma.

This study is the first to comprehensively describe micronutrient deficits in patients after endoscopic bariatric intervention. In addition, our data show the need for supplementation not only in bariatric surgery patients, but also in patients undergoing bariatric endoscopy.

Recent studies show several non-motor features that may precede the development of the motor symptoms of PD. The best known include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. The aim of this review is to summarize the currently available methods for diagnosing these premotor symptoms of PD which may help in the early diagnosis of PD.

Mixed-phenotype acute leukemia (MPAL) is a rare disease with a poor prognosis. This review article evaluates the relevant literature and summarizes current knowledge and treatment of MPAL.

The first report on serial BNP monitoring in out-patients with a continuous-flow LVAD. BNP changes allow identification of clinical events with the need for further diagnostic and therapeutic interventions.

Retroperitoneal tumors are relatively common, the impairment spectrum is broad, and safe establishment of correct diagnosis is crucial for the planning of further therapies. CT-guided biopsy using a percutaneous approach is a suitable interventional method with comparable diagnostic accuracy to surgical excision, but significantly less invasive.

The article provides an up-to-date overview of the current awareness of a new type of coronavirus. It is introduced with current information on the course of COVID-19 infections. The authors further offer recommendations on how to proceed with possible modification of immunomodulatory therapy in multiple sclerosis in the light of COVID-19 infection, since it is more difficult for physicians to recommend appropriate therapy if a patient develops COVID-19, especially if the patient is also suffering from another disease that may be exacerbated by a new type of coronavirus.

Study of the tear and ocular tissue metabolome may help us understand the metabolism of normal ocular tissues and mechanisms in disease, to discover inter-individual variations within the ocular environment and, thus improve diagnosis and prognosis. Metabolomic profiling of tear, aqueous humor and vitreous samples is useful for identifying biomarkers for more precise diagnosis, prognosis, and therapy.

This initial experience and preliminary results confirm the safety of the combined treatment modality of CRS/HIPEC although the results are limited by the size and heterogeneity of the cohort. More complications were seen in HIPEC with oxaliplatin in the presented cohort.

Chromosomal abnormalities of the melanoma can accurately predict the risk of metastases in affected patients. Testing is routinely carried out in oncology care in the United States and in some European states. These are the first results from the Czech population.

This study is the first to collate multicenter data on the epidemiology of HAP in the Central European Region. The patient cohort was divided into early- and late-onset HAP subgroups. A subgroup of patients with VAP was assessed separately. The study focuses on relationships between 30-day patient mortality and type of HAP, etiologic agent and type of antibiotic used for initial empirical therapy. The study reports on the epidemiology in the above region with respect to the incidence of etiologic agents causing HAP and provides an overview of treatment efficacy and adequacy of antibiotic therapy.

The goal was to assess the frequency of paraneoplastic neurological disorders in patients with advanced malignancy. Hypotension may be a symptom of paraneoplastic neuropathy

The authors present a study comparing the strategy of early and standard discharge in selected patients after myocardial infarction with ST-segment elevation (STEMI). The results show the possibility and safety of a length of hospital stay of 48-72 h and further support the recently released new version of ESC guidelines for STEMI in terms of the level of evidence for the strategy with the shorter recommended length of hospital stay.

The study followed a cohort of patients in the immediate days after stroke to assess the frequency of post-stroke spasticity (PSS) and to identify potential risk factors for PSS development. Better understanding of the evolution of the disorder along with identification of PSS risk factors could lead to earlier treatment and better outcomes. Knowledge of the epidemiology of PSS in Czech Stroke Centers should help with aftercare organization.

Quercetin is a widely distributed compound isolated from plants and is one of the most abundant dietary flavonoids. It is able to modulate expression of miRNA, many of which are recognized as oncogenic or tumor suppressor miRNAs. This review is a critical evaluation of recent research on miRNAs modulated by quercetin.