Fulltext search in archive

The blood cell count-derived ratios are easy to gain and might help in therapy decision processes, especially if there are more available options.

Lung cancer is the most common type of cancer in the world. It is unclear whether the concentrations of chemokines at the time of NSCLC (non-small cell lung cancer) diagnosis differ from healthy controls and reflect the extent of NSCLC. This study focuses on chemokine concentrations in the plasma of patients with resectable NSCLC vs healthy individuals and chemokine concentrations according to stage of NSCLC.

This 10-year follow-up indicates that B-TUERP is a safe and highly effective treatment for symptomatic BPH with lower reoperation rates. UDS value plays an important role in the preoperative judgment of surgical indications and the prediction of postoperative effect. Age, OABSS, PSA, MCC and DO may be critical predictors for urge incontinence after B-TUERP.

Antimetabolites remdesivir and favipiravir were repurposed as treatment options for Covid-19. Both drugs possess antiviral properties by mimicking purine RNA constituents but the detailed processes of their antimetabolite actions differ, making these molecules unique in their mechanisms of anti-Covid-19 action. This article compares the chemical and pharmacological proprieties of these drugs in addition to their role as anti-Covid 19 agents based on data obtained from clinical trials.

Inflammatory periodontal diseases are related to dental plaque formation and are influenced by its microbial composition and the host immune system. The dry socket (alveolar osteitis), which may occur as an inflammatory complication after third molar extraction, is similar in many ways. For this reason, efforts are currently underway to formulate preparations that inhibit dental plaque formation and suppress inflammation. The results of this pilot study show that the combination of the phenolic fraction of Lonicera caerulea fruit and Macleaya cordata alkaloids has beneficial effects on antioxidant imbalance and inflammation both in vitro and in a clinical study.

This is an analysis of post-acute COVID symptoms and the pulmonary function test (PFT) results in patients surviving the native strain of the virus (Wuhan variant). There were 785 subjects (345 male) mean age 53.8 (SD 14.6); PFT results showed a decrease with disease severity; anosmia during the acute phase was associated with mild course of the disease, persisting dyspnoea was more frequent in the more severe disease groups; female sex was identified as a possible risk factor for persisting symptoms in the post-acute phase.

This paper maps the etiology of mesothelioma with respect to current risks and the situation where the asbestos ban is in place.  It shows what other factors may apply and under what circumstances. Also, what are the possible routes of asbestos exposure today.

Postdischarge nausea and vomiting (PDNV) is the main cause of patient´s discomfort, worsens postoperative morbidity and put the child at risk of dehydrataion, dehiscence of surgical wound, bleeding and hospital readmission in the most serious cases. This paper reviews currently available data on the incidence, risk factors and management of postdischarge nausea and vomiting (PDNV) in pediatric patients. This narrative review is extended by an observational study of the incidence of PDNV.

Uterus transplantation appears to be a perspective treatment modality of absolute uterine factor infertility but it is still at an experimental stage worldwide. In this article, observational data on pregnancy outcomes, neonatal course, growth trajectory and 3-year follow-up in two children born at our institution in 2019 to mothers after uterus transplantation were analyzed, including assessment of neurodevelopment using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). No abnormalities were observed in either prematurely born babies in terms of the neonatal course and 3-year follow-up, including the neurodevelopmental status. This is the first ever report on neurodevelopmental outcomes in children born after uterus transplantation.

This is a review of current and new methods for improving on the sensitivity of biliary stenoses examinations, especially in relation to suspected carcinoma. Included are fluorescence in situ hybridization, next generation sequencing, the immunocolorimetric ELISA test, methylation markers of DNA and liquid. biopsy.

Visual field defects persist after antibiotic treatment in one third of patients with syphilitic uveitis. The observation supports adjacent systemic corticosteroid treatment for severe forms of syphilitic uveitis and/or neuritis.

This case report describes the management of treatment of HCL in a 53-year-old woman who developed a rare lung condition as part of the activity of the hematological disease. The authors present the differential diagnosis of pulmonary disease in patients with HCL and the treatment approach in these patients.

Over 40 monitoring methods of micro-vascular flaps have been reported in the scientific literature and it is difficult to discern the benefits of these over other methods or over direct visual monitoring, the standard method. In this review, we collated all reported monitoring methods to date and critically assessed their value including for practical use. We found that direct visual monitoring remains the most used, is very reliable and cheapest method for micro-vascular flap assessment. Only Doppler ultrasound, laser Doppler flowmetry and near infrared spectroscopy show any evidence of greater value but they require special equipment, experienced personnel and are more expensive.

The thromboprophylactic protocol using a standard fixed dose of enoxaparin very efficiently prevents deep vein thrombosis in a mixed ICU population including high risk patients. Measured low levels of anti-Xa activity are not associated with DVT incidence.

Non-invasive screening for colorectal cancer relies on fecal occult blood testing which can detect up to 80% of asymptomatic cases. Besides strategies that depend on detection of tumor-specific genetic material, cancer-associated microbiota are another source of markers capable of reducing the ≥20% false negative rate of the current screening. In this review, we assess the potential of toxigenic gram-negative bacteria as such markers and recommend those best suited for clinical trials.

The article briefly summarizes current knowledge of the phenotypic and functional diversity of macrophages in solid tumors in relation to their potential influence on the course of the disease and on its susceptibility to treatment.

This article reviews the role of biomarkers that could be used in the diagnosis and treatment of pelviureteral junction obstruction in children.

This case report describes a patient with lung adenocarcinoma harbouring a mutation of epidermal growth factor receptor (EGFR), treated with several lines of therapy including targeted tyrosine kinase inhibitors. A rare transformation of lung adenocarcinoma into small-cell lung cancer was confirmed by biopsies and by the finding of EGFR mutation in the sample of SCLC, which otherwise is never found in SCLC. This is the first case of a well proven transformation of lung adenocarcinoma into SCLC in our department, and also in Slovak Republic and the Czech Republic to be published.

The paper gives an overview of current visual neuroprostheses and explains their failures. In the second part it presents a new method based on transcranial stimulation of functional cells of the visual cortex. This technology is protected by a patent.

Endoscopic ear surgery is associated with less postoperative pain and smaller consumption of painkillers than the conventional microscopic ear surgery. It is rather the transmeatal approach, and not the endoscope itself that reduces postoperative pain.

These data analyses are the first for cabozantinib-treated patients in the Czech Republic. The evaluation of treatment outcomes and tolerance in an initial group of treated patients with metastatic renal cell carcinoma provides important evidence for informing future treatment decisions.

This paper focuses on potential novel diagnostic markers MMP 19 and RAGE in inflammatory bowel diseases and colorectal cancer.

This review is focused on the influence of psychological stress on the metabolism of antidepressants and anxiolytics mediated by the enzymes of Phase I – cytochromes P450, as there is increasing evidence that stress can alter drug pharmacokinetics and drug metabolism, hence there is a risk of less effective drug metabolism and increased side effects.

Odontogenic keratocysts, skeletal abnormalities and multiple basal cell carcinomas are the main kriteria for clinical manifestation of nevoid basal cell carcinoma (NBCCS, Gorlin Goltz syndrome). Mutations of PTCH1 gene are thought to be the cause of this disease. These abnormalities can be transmitted from one generation to another and lead to a familial occurence of the disease. The authors found a familial manifestation of NBCCS in two pairs of patients. With regard to the possibility of familial occurence of NBCCS, it is necessary to pay increased attention to family history and, if necessary, to ensure clinical and genetic examination of parents and other family members.

In the past, supernumerary teeth caused mainly esthetic and sometimes orthodontic problems. Recently, successful allo- and auto-transplantation of these teeth have been reported, but studies on their durability and resistance to tooth decay still do not exist. It is clear that the degree of mineralization is very important factor for the resistance. The goal of this study was to determine the differences in inorganic mineral content in supernumerary and healthy teeth.

The optimal treatment for paroxysmal hypertension or pseudopheochromocytoma has not been established. We added sertraline, 50 mg once daily, to the current medication of 64 patients with symptomatic paroxysmal hypertension. Within 3 months of treatment, sertraline effectively removed or reduced symptoms of paroxysmal hypertension in the majority (75%) of patients. Symptoms of paroxysmal hypertension fully subsided in 50% and were partially reduced in 25% of patients.

This study is the first to comprehensively describe micronutrient deficits in patients after endoscopic bariatric intervention. In addition, our data show the need for supplementation not only in bariatric surgery patients, but also in patients undergoing bariatric endoscopy.

This review opens up new perspectives for the treatment of IBD and CRC. In particular, the use of EVs derived from the intestinal microbiota could represent an innovative, safe and effective therapeutic strategy, as an adjuvant therapy for these pathologies.

Low-grade fibromyxoid sarcoma is a rare tumor of the paranasal sinuses with high bleeding potential and so embolisation of the tumor prior to the surgical resection should be considered.